Imatinib-Loaded Micelles of Hyaluronic Acid Derivatives for Potential Treatment of Neovascular Ocular Diseases

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4 Citazioni (Scopus)

Abstract

In this work, new micellar systems able to cross corneal barrier and to improve the permeation of imatinib free base were prepared and characterized. HA-EDA-C16, HA-EDA-C16−PEG, and HA-EDA-C16−CRN micelles were synthesized starting from hyaluronic acid (HA), ethylenediamine (EDA), hexadecyl chains (C16), polyethylene glycol (PEG), or L-carnitine (CRN). These nanocarriers showed optimal particle size and mucoadhesive properties. Imatinibloaded micelles were able to interact with corneal barrier and to promote imatinib transcorneal permeation and penetration. In addition, a study was conducted to understand the in vitro imatinib inhibitory effect on a choroidal neovascularization process. Imatinib released from polymeric micelles was able to inhibit endothelial cell sprouting and to promote cell tube disruption.
Lingua originaleEnglish
pagine (da-a)5031-5045
Numero di pagine15
RivistaMolecular Pharmaceutics
Volume15
Stato di pubblicazionePublished - 2018

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ethylenediamine
Eye Diseases
Micelles
Hyaluronic Acid
Choroidal Neovascularization
Carnitine
Particle Size
Endothelial Cells
Imatinib Mesylate

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

Cita questo

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title = "Imatinib-Loaded Micelles of Hyaluronic Acid Derivatives for Potential Treatment of Neovascular Ocular Diseases",
abstract = "In this work, new micellar systems able to cross corneal barrier and to improve the permeation of imatinib free base were prepared and characterized. HA-EDA-C16, HA-EDA-C16−PEG, and HA-EDA-C16−CRN micelles were synthesized starting from hyaluronic acid (HA), ethylenediamine (EDA), hexadecyl chains (C16), polyethylene glycol (PEG), or L-carnitine (CRN). These nanocarriers showed optimal particle size and mucoadhesive properties. Imatinibloaded micelles were able to interact with corneal barrier and to promote imatinib transcorneal permeation and penetration. In addition, a study was conducted to understand the in vitro imatinib inhibitory effect on a choroidal neovascularization process. Imatinib released from polymeric micelles was able to inhibit endothelial cell sprouting and to promote cell tube disruption.",
author = "{Di Prima}, Giulia and Flavia Bongiov{\`i} and Calogero Fiorica and Gaetano Giammona and Giovanna Pitarresi and Palumbo, {Fabio Salvatore} and {Di Prima}, Giulia and Gaetano Giammona",
year = "2018",
language = "English",
volume = "15",
pages = "5031--5045",
journal = "Molecular Pharmaceutics",
issn = "1543-8384",
publisher = "American Chemical Society",

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TY - JOUR

T1 - Imatinib-Loaded Micelles of Hyaluronic Acid Derivatives for Potential Treatment of Neovascular Ocular Diseases

AU - Di Prima, Giulia

AU - Bongiovì, Flavia

AU - Fiorica, Calogero

AU - Giammona, Gaetano

AU - Pitarresi, Giovanna

AU - Palumbo, Fabio Salvatore

AU - Di Prima, Giulia

AU - Giammona, Gaetano

PY - 2018

Y1 - 2018

N2 - In this work, new micellar systems able to cross corneal barrier and to improve the permeation of imatinib free base were prepared and characterized. HA-EDA-C16, HA-EDA-C16−PEG, and HA-EDA-C16−CRN micelles were synthesized starting from hyaluronic acid (HA), ethylenediamine (EDA), hexadecyl chains (C16), polyethylene glycol (PEG), or L-carnitine (CRN). These nanocarriers showed optimal particle size and mucoadhesive properties. Imatinibloaded micelles were able to interact with corneal barrier and to promote imatinib transcorneal permeation and penetration. In addition, a study was conducted to understand the in vitro imatinib inhibitory effect on a choroidal neovascularization process. Imatinib released from polymeric micelles was able to inhibit endothelial cell sprouting and to promote cell tube disruption.

AB - In this work, new micellar systems able to cross corneal barrier and to improve the permeation of imatinib free base were prepared and characterized. HA-EDA-C16, HA-EDA-C16−PEG, and HA-EDA-C16−CRN micelles were synthesized starting from hyaluronic acid (HA), ethylenediamine (EDA), hexadecyl chains (C16), polyethylene glycol (PEG), or L-carnitine (CRN). These nanocarriers showed optimal particle size and mucoadhesive properties. Imatinibloaded micelles were able to interact with corneal barrier and to promote imatinib transcorneal permeation and penetration. In addition, a study was conducted to understand the in vitro imatinib inhibitory effect on a choroidal neovascularization process. Imatinib released from polymeric micelles was able to inhibit endothelial cell sprouting and to promote cell tube disruption.

UR - http://hdl.handle.net/10447/323088

M3 - Article

VL - 15

SP - 5031

EP - 5045

JO - Molecular Pharmaceutics

JF - Molecular Pharmaceutics

SN - 1543-8384

ER -