Il coma tossico

Toxic coma is an extremely severe clinic situation. It israre, but involves several toxic substances and causes differentp roblems concerning the treatment related. Among these sub -stances there are exterioganophosphorics, metals, ethylen gly -cole, carbon monoxide, etc.First of all the teraphy must control the patient’s cardiacvascular, respiratory and renal parameters. After that we needto carry on a careful anamnesis and an analysis aimed at fin -ding the toxic substance. It is really important to know thepharmacokinetics and the distribution volume, the modulationof the acid-base balance, as for example in case of barbituratesand the ractivity of the patient to the toxic element.The treatment must be multi disciplinar and it has tointegrate and compleate the experience of the resuscitator andthe toxicologist. We have to underline the environmental pre -vention as well, particularly focusing on high risk jobplaces.