IL-33/IL-31 Axis: A Potential Inflammatory Pathway

Elvira Ventura Spagnolo, Michele Navarra, Marco Casciaro, Eleonora Di Salvo, Marco Casciaro, Sebastiano Gangemi

Risultato della ricerca: Articlepeer review

40 Citazioni (Scopus)


Cytokines play an important role in the regulation of the immune system (adaptive and innate). Given their importance inproinflammatory processes, cytokines have been used for understanding the pathogenesis and as biomarkers in many diseases.IL-31 and IL-33 are still considered novel cytokines. IL-31 controls signalling and regulates a huge amount of biologicalfunctions: it induces proinflammatory cytokines, regulates cell proliferation, and is involved also in tissue remodelling. On theother hand, IL-33 has been identified as an “alarmin” released from the epithelial cells and from different human tissues andorgans after a damage following, that is, an inflammatory process. The aim of this literature review is to strengthen thehypothesis about an IL-31/IL-33 axis by evaluating the most recent studies linking these two cytokines. Literature data showedthat, in many cases, IL-31 and IL-33 are linked to each other and that their expression is correlated with disease severity. Thepresence of one interleukin might stimulate the induction of the other, amplifying inflammation and the consequent detrimentalprocesses. In a near future, influencing their balance could be helpful in modulating the first responses of the immune system inorder to prevent the development of many inflammation-related diseases.
Lingua originaleEnglish
pagine (da-a)1-8
Numero di pagine8
RivistaMediators of Inflammation
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1300.1307???


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