IL-17 polarization of MAIT cells is derived from the activation of two different pathways

Giovanni Triolo; Laura Saieva; Riccardo Alessandro; Giuliana Guggino; Francesco Ciccia; Francesco Dieli

IL-17 polarization of MAIT cells is derived from the activation of two different pathways

Giovanni Triolo, Laura Saieva, Riccardo Alessandro, Giuliana Guggino, Francesco Ciccia, Francesco Dieli

Risultato della ricerca: Article › peer review

Abstract

MAIT cells are expanded in salivary glands of patients with Sjogren's syndrome and are IL-17 polarized. IL-7 and IL-23 induce IL-17 production activating two different pathways: IL-7 stimulation induces in fact a significant STAT3 and HIF1alpha upregulation, conversely, IL-23 stimulation significantly induces RORc overexpression in MAIT cells of patients with Sjogren's syndrome.

Lingua originale	English
pagine (da-a)	2002-2003
Numero di pagine	2
Rivista	European Journal of Immunology
Volume	47
Stato di pubblicazione	Published - 2017

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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title = "IL-17 polarization of MAIT cells is derived from the activation of two different pathways",

abstract = "MAIT cells are expanded in salivary glands of patients with Sjogren's syndrome and are IL-17 polarized. IL-7 and IL-23 induce IL-17 production activating two different pathways: IL-7 stimulation induces in fact a significant STAT3 and HIF1alpha upregulation, conversely, IL-23 stimulation significantly induces RORc overexpression in MAIT cells of patients with Sjogren's syndrome.",

keywords = "IL-17, IL-23, IL-7, Immunology, Immunology and Allergy, MAIT cells, RORc, STAT3, Sjogren's Syndrome, IL-17, IL-23, IL-7, Immunology, Immunology and Allergy, MAIT cells, RORc, STAT3, Sjogren's Syndrome",

author = "Giovanni Triolo and Laura Saieva and Riccardo Alessandro and Giuliana Guggino and Francesco Ciccia and Francesco Dieli",

year = "2017",

language = "English",

volume = "47",

pages = "2002--2003",

journal = "European Journal of Immunology",

issn = "0014-2980",

publisher = "Wiley-VCH Verlag",

}

TY - JOUR

T1 - IL-17 polarization of MAIT cells is derived from the activation of two different pathways

AU - Triolo, Giovanni

AU - Saieva, Laura

AU - Alessandro, Riccardo

AU - Guggino, Giuliana

AU - Ciccia, Francesco

AU - Dieli, Francesco

PY - 2017

Y1 - 2017

N2 - MAIT cells are expanded in salivary glands of patients with Sjogren's syndrome and are IL-17 polarized. IL-7 and IL-23 induce IL-17 production activating two different pathways: IL-7 stimulation induces in fact a significant STAT3 and HIF1alpha upregulation, conversely, IL-23 stimulation significantly induces RORc overexpression in MAIT cells of patients with Sjogren's syndrome.

AB - MAIT cells are expanded in salivary glands of patients with Sjogren's syndrome and are IL-17 polarized. IL-7 and IL-23 induce IL-17 production activating two different pathways: IL-7 stimulation induces in fact a significant STAT3 and HIF1alpha upregulation, conversely, IL-23 stimulation significantly induces RORc overexpression in MAIT cells of patients with Sjogren's syndrome.

KW - IL-17

KW - IL-23

KW - IL-7

KW - Immunology

KW - Immunology and Allergy

KW - MAIT cells

KW - RORc

KW - STAT3

KW - Sjogren's Syndrome

KW - IL-17

KW - IL-23

KW - IL-7

KW - Immunology

KW - Immunology and Allergy

KW - MAIT cells

KW - RORc

KW - STAT3

KW - Sjogren's Syndrome

UR - http://hdl.handle.net/10447/245512

UR - http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-4141

M3 - Article

VL - 47

SP - 2002

EP - 2003

JO - European Journal of Immunology

JF - European Journal of Immunology

SN - 0014-2980

ER -