MAIT cells are expanded in salivary glands of patients with Sjogren's syndrome and are IL-17 polarized. IL-7 and IL-23 induce IL-17 production activating two different pathways: IL-7 stimulation induces in fact a significant STAT3 and HIF1alpha upregulation, conversely, IL-23 stimulation significantly induces RORc overexpression in MAIT cells of patients with Sjogren's syndrome.
|Numero di pagine||2|
|Rivista||European Journal of Immunology|
|Stato di pubblicazione||Published - 2017|
All Science Journal Classification (ASJC) codes
- Immunology and Allergy