Abstract

MAIT cells are expanded in salivary glands of patients with Sjogren's syndrome and are IL-17 polarized. IL-7 and IL-23 induce IL-17 production activating two different pathways: IL-7 stimulation induces in fact a significant STAT3 and HIF1alpha upregulation, conversely, IL-23 stimulation significantly induces RORc overexpression in MAIT cells of patients with Sjogren's syndrome.
Lingua originaleEnglish
pagine (da-a)2002-2003
Numero di pagine2
RivistaEuropean Journal of Immunology
Volume47
Stato di pubblicazionePublished - 2017

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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