AbstractAging has a striking impact on the heart and the vascular system, particularly on the large elastic arteries (i.e.,aorta), resulting in a multitude of changes at different structural and functional levels. As result, medialdegeneration (MD) occurs. A characteristic example of MD is sporadic thoracic aortic aneurysm (S-TAA),whose patho-physiological mechanisms remain unclear. In this study, typical MD morphological phenotypeswere researched in S-TAA cases and control aorta specimens by histopathological and immunohistochemicalanalyses. Three phenotypes (I, II, and III) were detected, but mainly the phenotype III was observed. Elevatedcystic MD, plurifocal medial apoptosis, and increased metalloproteinase-9 amount characterize it. In addition,it was significantly correlated with the severity of elastic fragmentation, hypertension, and smoking, andparticularly with advancing age. Thus, phenotype III might represent the typical MD phenotype associated withS-TAA in old people that have a major risk of aorta rupture and dissection independently on aneurysmdiameter. This might permit the assumption that phenotype III with its typical histological abnormalities is anoptimal biomarker of rupture and/or dissection in aged individuals and is useful both for applying differentsurgical approaches and providing appropriate surgical indications
|Numero di pagine||5|
|Stato di pubblicazione||Published - 2014|
All Science Journal Classification (ASJC) codes
- Geriatrics and Gerontology
Caruso, C., Balistreri, C. R., Vaccarino, L., Candore, G., Lio, D., Maresi, E., & Pisano, C. (2014). Identification of Three Particular MorphologicalPhenotypes in Sporadic Thoracic Aortic Aneurysm:Phenotype III As Sporadic Thoracic AorticAneurysm Biomarker in Aged Individuals. Rejuvenation Research, 17, 192-196.