Identification of SNPs in the promoter of β-lactoglobulin gene in three Sicilian goat breeds

Maria Teresa Sardina, Baldassare Portolano, Emilio Scotti, Silvia Braglia

Risultato della ricerca: Articlepeer review

1 Citazioni (Scopus)

Abstract

The aim of this work was to sequence the full-length promoter region of the caprineβ-lactoglobulin (β-lg) gene in three Sicilian goat breeds (Girgentana, Maltese, and Derivata di Siria),in order to identify polymorphisms, to search for transcription factors (TFs) sites, and to check if polymorphismsfound lay within TFs binding sites. The promoter region of β-lg gene in Sicilian goat breedsshowed high level of polymorphism due to the presence of 31 SNPs. Binding sites for several TFs werefound within the goat β-lg promoter and within regions conserved between ovine and caprine species.Two SNPs were detected within TFs binding sites, such as MPBF and NF-I. Further studies are inprogress to confirm polymorphic sites, to evaluate the possible effect of these mutations on bindingaffinity of TFs, their relationship with β-lg gene expression, and the functional role of SNPs within theTFs sites of the promoter region on milk traits
Lingua originaleEnglish
pagine (da-a)147-149
Numero di pagine3
RivistaItalian Journal of Animal Science
Volume8
Stato di pubblicazionePublished - 2009

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology

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