Identification of Key miRNAs in Regulation of PPI Networks

Giosue' Lo Bosco, Alfonso Urso

Risultato della ricerca: Conference contribution

Abstract

In this paper, we explore the interaction between miRNA and deregulated proteins in some pathologies. Assuming that miRNA can influence mRNA and consequently the proteins regulation, we explore this connection by using an interaction matrix derived from miRNA-target data and PPI network interactions. From this interaction matrix and the set of deregulated proteins, we search for the miRNA subset that influences the deregulated proteins with a minimum impact on the not deregulated ones. This regulation problem can be formulated as a complex optimization problem. In this paper, we have tried to solve it by using the Genetic Algorithm Heuristic. As the main result, we have found a set of miRNA that is known to be involved in disease development.
Lingua originaleEnglish
Titolo della pubblicazione ospiteComputational Intelligence Methods for Bioinformatics and Biostatistics 15th International Meeting, CIBB 2018, Caparica, Portugal, September 6–8, 2018
Pagine107-117
Numero di pagine11
Stato di pubblicazionePublished - 2020

Serie di pubblicazioni

NomeLECTURE NOTES IN COMPUTER SCIENCE

Fingerprint

Proteins
Pathology
Genetic algorithms
Messenger RNA

Cita questo

Lo Bosco, G., & Urso, A. (2020). Identification of Key miRNAs in Regulation of PPI Networks. In Computational Intelligence Methods for Bioinformatics and Biostatistics 15th International Meeting, CIBB 2018, Caparica, Portugal, September 6–8, 2018 (pagg. 107-117). (LECTURE NOTES IN COMPUTER SCIENCE).

Identification of Key miRNAs in Regulation of PPI Networks. / Lo Bosco, Giosue'; Urso, Alfonso.

Computational Intelligence Methods for Bioinformatics and Biostatistics 15th International Meeting, CIBB 2018, Caparica, Portugal, September 6–8, 2018. 2020. pag. 107-117 (LECTURE NOTES IN COMPUTER SCIENCE).

Risultato della ricerca: Conference contribution

Lo Bosco, G & Urso, A 2020, Identification of Key miRNAs in Regulation of PPI Networks. in Computational Intelligence Methods for Bioinformatics and Biostatistics 15th International Meeting, CIBB 2018, Caparica, Portugal, September 6–8, 2018. LECTURE NOTES IN COMPUTER SCIENCE, pagg. 107-117.
Lo Bosco G, Urso A. Identification of Key miRNAs in Regulation of PPI Networks. In Computational Intelligence Methods for Bioinformatics and Biostatistics 15th International Meeting, CIBB 2018, Caparica, Portugal, September 6–8, 2018. 2020. pag. 107-117. (LECTURE NOTES IN COMPUTER SCIENCE).
Lo Bosco, Giosue' ; Urso, Alfonso. / Identification of Key miRNAs in Regulation of PPI Networks. Computational Intelligence Methods for Bioinformatics and Biostatistics 15th International Meeting, CIBB 2018, Caparica, Portugal, September 6–8, 2018. 2020. pagg. 107-117 (LECTURE NOTES IN COMPUTER SCIENCE).
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AB - In this paper, we explore the interaction between miRNA and deregulated proteins in some pathologies. Assuming that miRNA can influence mRNA and consequently the proteins regulation, we explore this connection by using an interaction matrix derived from miRNA-target data and PPI network interactions. From this interaction matrix and the set of deregulated proteins, we search for the miRNA subset that influences the deregulated proteins with a minimum impact on the not deregulated ones. This regulation problem can be formulated as a complex optimization problem. In this paper, we have tried to solve it by using the Genetic Algorithm Heuristic. As the main result, we have found a set of miRNA that is known to be involved in disease development.

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