Identification of Biomarkers in Cerebrospinal Fluid and Serumof Multiple Sclerosis Patients by Immunoproteomics Approach

Giuseppe Salemi, Giovanni Savettieri, Paolo Ragonese, Giacomo De Leo, Riccardo Alessandro, Simona Fontana, Paolo Colomba, Giovanni Duro, Riccardo Alessandro, Maria Antonietta Mazzola

Risultato della ricerca: Articlepeer review

7 Citazioni (Scopus)

Abstract

Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating diseaseof the central nervous system. At present, the molecular mechanisms causing the initiation,development and progression of MS are poorly understood, and no reliable proteinaceousdisease markers are available. In this study, we used an immunoproteomics approachto identify autoreactive antibodies in the cerebrospinal fluid of MS patients to use as candidatemarkers with potential diagnostic value. We identified an autoreactive anti-transferrin antibodythat may have a potential link with the development and progression of MS. We found this antibody at high levels also in the serum of MS patients and created an immunoenzymaticassay to detect it. Because of the complexity and heterogeneity of multiple sclerosis, it isdifficult to find a single marker for all of the processes involved in the origin and progressionof the disease, so the development of a panel of biomarkers is desirable, and anti-transferrinantibody could be one of these.
Lingua originaleEnglish
pagine (da-a)23269-23282
Numero di pagine14
RivistaInternational Journal of Molecular Sciences
Volume15
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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