Identification of a novel mutation in the alpha-galactosidase A gene in patients with Fabry disease.

Antonio Pinto, Antonino Tuttolomondo, Daniele Francofonte, Carmela Zizzo, Antonia Nucera, Giuseppe Albeggiani, Paolo Colomba, Francesco Iemolo, Giuseppe Albeggiani, Giovanni Duro

Risultato della ricerca: Articlepeer review

6 Citazioni (Scopus)


OBJECTIVES: Mutation analysis of the alpha-galactosidase A (GLA) gene is a valuable tool for the diagnosis of affected families. In our work, we analyze about one thousand samples per year from patients suspected of having Fabry disease (FD).DESIGN AND METHODS: We carried out high resolution melting analysis (HRM) and DNA sequencing of all the exons of the GLA gene. We also assayed the alpha-galactosidase A activity in patients' blood.RESULTS: In some members of one family, we identified a new mutation in the GLA gene, c.614delC. This is a deletion of a single nucleotide, a cytosine, in exon 4 of the gene which causes a frameshift mutation.CONCLUSIONS: Patients with the c.614delC mutation show classical clinical manifestations of FD, and the male patient has no alpha-galactosidase A activity. These data suggest that c.614delC is a novel mutation associated with FD.
Lingua originaleEnglish
pagine (da-a)839-841
Numero di pagine3
RivistaClinical Biochemistry
Stato di pubblicazionePublished - 2012

All Science Journal Classification (ASJC) codes

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