Hysteroscopic resection of the septum improves the pregnancy rate of women with unexplained infertility: a prospectine controlled trial

Renato Venezia, Antonino Perino, Nicola Colacurci, Luigi Cobellis, Antonio Mollo, Carlo Alviggi, Pasquale De Franciscis, Giuseppe De Placido

Risultato della ricerca: Articlepeer review

144 Citazioni (Scopus)

Abstract

Objective: To assess fecundity of infertile women after surgical correction of uterine septum. Design: Prospective controlled trial. Setting: Three academic infertility clinics. Patient(s): Forty-four women affected by septate uterus and otherwise unexplained infertility represented the study group (group A), and 132 women with unexplained infertility were enrolled as control subjects (group B). Intervention(s): Hysteroscopic metroplasty was performed in group A, and group B was managed expectantly. All women were followed-up for 1 year without any other intervention. Main Outcome Measure(s): Fecundity rate was calculated as the number of pregnancies per 100 person-months. Result(s): Pregnancy rate (38.6% vs. 20.4%) and live birth rate (34.1% and 18.9%) were significantly higher in group A than in group B. The survival analysis showed that the probability of a pregnancy in the twelve-months follow up was significantly higher in patients who had undergone metroplasty than in women with unexplained infertility. The corresponding fecundity (10-week pregnancy) rates were 4.27 and 1.92 person-months in women who had undergone metroplasty and in women with unexplained infertility, respectively. Conclusion(s): Hysteroscopic resection of the septum improves fecundity of women with septate uterus and otherwise unexplained infertility. Patients with septate uterus and no other cause of sterility have a significantly higher probability of conceiving after removal of the septum than patients affected by idiopathic sterility. © 2009 American Society for Reproductive Medicine.
Lingua originaleEnglish
pagine (da-a)2628-2631
Numero di pagine4
RivistaFertility and Sterility
Volume91
Stato di pubblicazionePublished - 2009

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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