Abstract

Cognitive impairment is common in elderly people and represents clinical feature of neurodegenerative diseases. Not all of patients with Mild Cognitive Impairment (MCI) finally develop dementia and it is interesting to investigate the role of possible markers for early diagnosis. Hyperhomocysteinemia is associated to several pathologies including cognitive impairment; aim of this study is to evaluate the correlation between cognitive performance assessment and homocysteine plasma levels. Total 74 patients and 75 healthy controls were enrolled and MCI were defined by a MMSE score lower than 26 after adjustment for years of schooling. Homocysteine plasma levels were determined. Homocysteine levels significantly raised in patients with cognitive impairment and showed a significant negative association with MMSE score. Finally, our data show that a moderate risk of cognitive impairment could be associated to high homocysteine plasma levels.
Lingua originaleEnglish
pagine (da-a)1337-1340
Numero di pagine4
RivistaRESEARCH JOURNAL OF BIOLOGICAL SCIENCES
Volume3
Stato di pubblicazionePublished - 2008

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Hyperhomocysteinemia
Homocysteine
Neurodegenerative Diseases
Dementia
Cognitive Dysfunction
Early Diagnosis
Pathology

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title = "Hyperhomocysteinemia in patients with cognitive impairment",
abstract = "Cognitive impairment is common in elderly people and represents clinical feature of neurodegenerative diseases. Not all of patients with Mild Cognitive Impairment (MCI) finally develop dementia and it is interesting to investigate the role of possible markers for early diagnosis. Hyperhomocysteinemia is associated to several pathologies including cognitive impairment; aim of this study is to evaluate the correlation between cognitive performance assessment and homocysteine plasma levels. Total 74 patients and 75 healthy controls were enrolled and MCI were defined by a MMSE score lower than 26 after adjustment for years of schooling. Homocysteine plasma levels were determined. Homocysteine levels significantly raised in patients with cognitive impairment and showed a significant negative association with MMSE score. Finally, our data show that a moderate risk of cognitive impairment could be associated to high homocysteine plasma levels.",
keywords = "cognitive impairment, homocystein",
author = "Marcello Ciaccio and {Di Raimondo}, Domenico and Giulia Bivona and Rosachiara Carollo and Antonio Pinto and Giuseppe Licata and {Lo Sasso}, Bruna and Antonino Tuttolomondo and Chiara Bellia and Gaia Chiarello and {Di Sciacca}, Riccardo",
year = "2008",
language = "English",
volume = "3",
pages = "1337--1340",
journal = "RESEARCH JOURNAL OF BIOLOGICAL SCIENCES",
issn = "1815-8846",

}

TY - JOUR

T1 - Hyperhomocysteinemia in patients with cognitive impairment

AU - Ciaccio, Marcello

AU - Di Raimondo, Domenico

AU - Bivona, Giulia

AU - Carollo, Rosachiara

AU - Pinto, Antonio

AU - Licata, Giuseppe

AU - Lo Sasso, Bruna

AU - Tuttolomondo, Antonino

AU - Bellia, Chiara

AU - Chiarello, Gaia

AU - Di Sciacca, Riccardo

PY - 2008

Y1 - 2008

N2 - Cognitive impairment is common in elderly people and represents clinical feature of neurodegenerative diseases. Not all of patients with Mild Cognitive Impairment (MCI) finally develop dementia and it is interesting to investigate the role of possible markers for early diagnosis. Hyperhomocysteinemia is associated to several pathologies including cognitive impairment; aim of this study is to evaluate the correlation between cognitive performance assessment and homocysteine plasma levels. Total 74 patients and 75 healthy controls were enrolled and MCI were defined by a MMSE score lower than 26 after adjustment for years of schooling. Homocysteine plasma levels were determined. Homocysteine levels significantly raised in patients with cognitive impairment and showed a significant negative association with MMSE score. Finally, our data show that a moderate risk of cognitive impairment could be associated to high homocysteine plasma levels.

AB - Cognitive impairment is common in elderly people and represents clinical feature of neurodegenerative diseases. Not all of patients with Mild Cognitive Impairment (MCI) finally develop dementia and it is interesting to investigate the role of possible markers for early diagnosis. Hyperhomocysteinemia is associated to several pathologies including cognitive impairment; aim of this study is to evaluate the correlation between cognitive performance assessment and homocysteine plasma levels. Total 74 patients and 75 healthy controls were enrolled and MCI were defined by a MMSE score lower than 26 after adjustment for years of schooling. Homocysteine plasma levels were determined. Homocysteine levels significantly raised in patients with cognitive impairment and showed a significant negative association with MMSE score. Finally, our data show that a moderate risk of cognitive impairment could be associated to high homocysteine plasma levels.

KW - cognitive impairment

KW - homocystein

UR - http://hdl.handle.net/10447/64092

M3 - Article

VL - 3

SP - 1337

EP - 1340

JO - RESEARCH JOURNAL OF BIOLOGICAL SCIENCES

JF - RESEARCH JOURNAL OF BIOLOGICAL SCIENCES

SN - 1815-8846

ER -