Hybrid Gold/Silica/Quantum-Dots supramolecular-nanostructures encapsulated in polymeric micelles as potential theranostic tool for targeted cancer therapy

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6 Citazioni (Scopus)

Abstract

Efficient theranostic tools are today more and more frequently represented by the nano-sized systems. In this paper, polymeric micelles were produced and exploited to encapsulate both an antitumor drug (Doxorubicin) and gold core–shell quantum dots nanoparticles (Au-SiO2/QDs). α,β-poly(N-hydroxyethyl)-DL-aspartamide (PHEA) was functionalized with lipoic acid (LA), polyethylenglycol (PEG), and folic acid (FA) pendant moieties to obtain a synthetic derivative (PHEA-LA-PEG-FA) able to self assemble in aqueous medium giving rise to the formation of polymeric micelles exposing on their surface both targeting groups (FA) and hydrophilic chains (PEG). The drug carrying ability of PHEA-LA-PEG-FA micelles was here studied along with the cytotoxity of the obtained nanostructures toward breast cancer cells employing doxorubicin as a model anticancer drug. Finally, the properties of the gold-shell QDs incorporated into the micelles as cells imaging agent and photothermal anticancer treatment tool were explored.
Lingua originaleEnglish
pagine (da-a)38-47
Numero di pagine10
RivistaEuropean Polymer Journal
Volume105
Stato di pubblicazionePublished - 2018

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folic acid
lipoic acid
Micelles
Folic Acid
Thioctic Acid
Silicon Dioxide
Gold
Semiconductor quantum dots
therapy
Nanostructures
micelles
cancer
Silica
quantum dots
gold
silicon dioxide
drugs
Acids
Antineoplastic Agents
Doxorubicin

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)
  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

Cita questo

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title = "Hybrid Gold/Silica/Quantum-Dots supramolecular-nanostructures encapsulated in polymeric micelles as potential theranostic tool for targeted cancer therapy",
abstract = "Efficient theranostic tools are today more and more frequently represented by the nano-sized systems. In this paper, polymeric micelles were produced and exploited to encapsulate both an antitumor drug (Doxorubicin) and gold core–shell quantum dots nanoparticles (Au-SiO2/QDs). α,β-poly(N-hydroxyethyl)-DL-aspartamide (PHEA) was functionalized with lipoic acid (LA), polyethylenglycol (PEG), and folic acid (FA) pendant moieties to obtain a synthetic derivative (PHEA-LA-PEG-FA) able to self assemble in aqueous medium giving rise to the formation of polymeric micelles exposing on their surface both targeting groups (FA) and hydrophilic chains (PEG). The drug carrying ability of PHEA-LA-PEG-FA micelles was here studied along with the cytotoxity of the obtained nanostructures toward breast cancer cells employing doxorubicin as a model anticancer drug. Finally, the properties of the gold-shell QDs incorporated into the micelles as cells imaging agent and photothermal anticancer treatment tool were explored.",
author = "Cinzia Scialabba and Calogero Fiorica and Palumbo, {Fabio Salvatore} and Mariano Licciardi and Gaetano Giammona and {Li Volsi}, Anna and Michele D'Amico and Michele D'Amico and {Li Volsi}, Anna",
year = "2018",
language = "English",
volume = "105",
pages = "38--47",
journal = "European Polymer Journal",
issn = "0014-3057",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Hybrid Gold/Silica/Quantum-Dots supramolecular-nanostructures encapsulated in polymeric micelles as potential theranostic tool for targeted cancer therapy

AU - Scialabba, Cinzia

AU - Fiorica, Calogero

AU - Palumbo, Fabio Salvatore

AU - Licciardi, Mariano

AU - Giammona, Gaetano

AU - Li Volsi, Anna

AU - D'Amico, Michele

AU - D'Amico, Michele

AU - Li Volsi, Anna

PY - 2018

Y1 - 2018

N2 - Efficient theranostic tools are today more and more frequently represented by the nano-sized systems. In this paper, polymeric micelles were produced and exploited to encapsulate both an antitumor drug (Doxorubicin) and gold core–shell quantum dots nanoparticles (Au-SiO2/QDs). α,β-poly(N-hydroxyethyl)-DL-aspartamide (PHEA) was functionalized with lipoic acid (LA), polyethylenglycol (PEG), and folic acid (FA) pendant moieties to obtain a synthetic derivative (PHEA-LA-PEG-FA) able to self assemble in aqueous medium giving rise to the formation of polymeric micelles exposing on their surface both targeting groups (FA) and hydrophilic chains (PEG). The drug carrying ability of PHEA-LA-PEG-FA micelles was here studied along with the cytotoxity of the obtained nanostructures toward breast cancer cells employing doxorubicin as a model anticancer drug. Finally, the properties of the gold-shell QDs incorporated into the micelles as cells imaging agent and photothermal anticancer treatment tool were explored.

AB - Efficient theranostic tools are today more and more frequently represented by the nano-sized systems. In this paper, polymeric micelles were produced and exploited to encapsulate both an antitumor drug (Doxorubicin) and gold core–shell quantum dots nanoparticles (Au-SiO2/QDs). α,β-poly(N-hydroxyethyl)-DL-aspartamide (PHEA) was functionalized with lipoic acid (LA), polyethylenglycol (PEG), and folic acid (FA) pendant moieties to obtain a synthetic derivative (PHEA-LA-PEG-FA) able to self assemble in aqueous medium giving rise to the formation of polymeric micelles exposing on their surface both targeting groups (FA) and hydrophilic chains (PEG). The drug carrying ability of PHEA-LA-PEG-FA micelles was here studied along with the cytotoxity of the obtained nanostructures toward breast cancer cells employing doxorubicin as a model anticancer drug. Finally, the properties of the gold-shell QDs incorporated into the micelles as cells imaging agent and photothermal anticancer treatment tool were explored.

UR - http://hdl.handle.net/10447/292584

M3 - Article

VL - 105

SP - 38

EP - 47

JO - European Polymer Journal

JF - European Polymer Journal

SN - 0014-3057

ER -