Hyaluronic Acid-Based Micelles as Ocular Platform to Modulate the Loading, Release, and Corneal Permeation of Corticosteroids

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10 Citazioni (Scopus)

Abstract

The aim of this work is to prepare hyaluronic acid-based micelles as a platform to load corticosteroid drugs and to improve their corneal permeation after administration on the ocular surface. Three amphiphilic derivatives of hyaluronic acid (HA) are synthesized using different amounts of hexadecylamine (C16-NH2). HAC16a, HAC16b, and HAC16c derivatives are able to form micelles by the cosolvent evaporation method and to entrap corticosteroids (dexamethasone, triamcinolone, triamcinolone acetonide). HAC16a and HAC16b micelles show the best results in terms of drug loading and particle size. They are also able to improve drug release compared to free drug solution or suspension. In addition, HAC16b micelles show an optimal mucoadhesion and compatibility with human corneal epithelial cells. In vitro and ex vivo permeation studies of drug-loaded HAC16b micelles are performed to understand the ability of these micelles to act as penetration and/or permeation enhancers.
Lingua originaleEnglish
pagine (da-a)1700261-1-1700261-13
Numero di pagine13
RivistaMacromolecular Bioscience
Volume17
Stato di pubblicazionePublished - 2017

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Hyaluronic acid
Micelles
Hyaluronic Acid
Permeation
Adrenal Cortex Hormones
Pharmaceutical Preparations
Ophthalmic Administration
Derivatives
Triamcinolone
Triamcinolone Acetonide
Particle Size
Dexamethasone
Suspensions
Evaporation
Epithelial Cells
Particle size

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cita questo

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title = "Hyaluronic Acid-Based Micelles as Ocular Platform to Modulate the Loading, Release, and Corneal Permeation of Corticosteroids",
abstract = "The aim of this work is to prepare hyaluronic acid-based micelles as a platform to load corticosteroid drugs and to improve their corneal permeation after administration on the ocular surface. Three amphiphilic derivatives of hyaluronic acid (HA) are synthesized using different amounts of hexadecylamine (C16-NH2). HAC16a, HAC16b, and HAC16c derivatives are able to form micelles by the cosolvent evaporation method and to entrap corticosteroids (dexamethasone, triamcinolone, triamcinolone acetonide). HAC16a and HAC16b micelles show the best results in terms of drug loading and particle size. They are also able to improve drug release compared to free drug solution or suspension. In addition, HAC16b micelles show an optimal mucoadhesion and compatibility with human corneal epithelial cells. In vitro and ex vivo permeation studies of drug-loaded HAC16b micelles are performed to understand the ability of these micelles to act as penetration and/or permeation enhancers.",
author = "Mariano Licciardi and Gaetano Giammona and Palumbo, {Fabio Salvatore} and {Di Prima}, Giulia and Giovanna Pitarresi and Flavia Bongiov{\`i} and Mariano Licciardi and Gaetano Giammona",
year = "2017",
language = "English",
volume = "17",
pages = "1700261--1--1700261--13",
journal = "Macromolecular Bioscience",
issn = "1616-5187",
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TY - JOUR

T1 - Hyaluronic Acid-Based Micelles as Ocular Platform to Modulate the Loading, Release, and Corneal Permeation of Corticosteroids

AU - Licciardi, Mariano

AU - Giammona, Gaetano

AU - Palumbo, Fabio Salvatore

AU - Di Prima, Giulia

AU - Pitarresi, Giovanna

AU - Bongiovì, Flavia

AU - Licciardi, Mariano

AU - Giammona, Gaetano

PY - 2017

Y1 - 2017

N2 - The aim of this work is to prepare hyaluronic acid-based micelles as a platform to load corticosteroid drugs and to improve their corneal permeation after administration on the ocular surface. Three amphiphilic derivatives of hyaluronic acid (HA) are synthesized using different amounts of hexadecylamine (C16-NH2). HAC16a, HAC16b, and HAC16c derivatives are able to form micelles by the cosolvent evaporation method and to entrap corticosteroids (dexamethasone, triamcinolone, triamcinolone acetonide). HAC16a and HAC16b micelles show the best results in terms of drug loading and particle size. They are also able to improve drug release compared to free drug solution or suspension. In addition, HAC16b micelles show an optimal mucoadhesion and compatibility with human corneal epithelial cells. In vitro and ex vivo permeation studies of drug-loaded HAC16b micelles are performed to understand the ability of these micelles to act as penetration and/or permeation enhancers.

AB - The aim of this work is to prepare hyaluronic acid-based micelles as a platform to load corticosteroid drugs and to improve their corneal permeation after administration on the ocular surface. Three amphiphilic derivatives of hyaluronic acid (HA) are synthesized using different amounts of hexadecylamine (C16-NH2). HAC16a, HAC16b, and HAC16c derivatives are able to form micelles by the cosolvent evaporation method and to entrap corticosteroids (dexamethasone, triamcinolone, triamcinolone acetonide). HAC16a and HAC16b micelles show the best results in terms of drug loading and particle size. They are also able to improve drug release compared to free drug solution or suspension. In addition, HAC16b micelles show an optimal mucoadhesion and compatibility with human corneal epithelial cells. In vitro and ex vivo permeation studies of drug-loaded HAC16b micelles are performed to understand the ability of these micelles to act as penetration and/or permeation enhancers.

UR - http://hdl.handle.net/10447/249730

M3 - Article

VL - 17

SP - 1700261-1-1700261-13

JO - Macromolecular Bioscience

JF - Macromolecular Bioscience

SN - 1616-5187

ER -