Hyaluronic acid and beta cyclodextrins films for the release of corneal epithelial cells and dexamethasone

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17 Citazioni (Scopus)

Abstract

In this work we prepared hydrogels based on hyaluronic acid and β-cyclodextrins to sustain the release of both corneal epithelial cells and dexamethasone. This steroid is administered as eye drops several times per day to reduce the risk of rejection in the post operative period after the cornea transplantation and cell release techniques. Hydrogels were produced by crosslinking an amino derivative of hyaluronic acid, with the divinyl sulfone derivative of β-cyclodextrins, this last employed as a crosslinker and solubilizing agent. Drug release studies revealed that dexamethasone containing samples are able to extend the release of this drug for at least five days. Biological studies, conducted with human corneal epithelial cells, showed that it is possible to employ the hydrogels for the temporary seeding of the cells and their potential release onto the cornea.
Lingua originaleEnglish
pagine (da-a)281-290
Numero di pagine10
RivistaCarbohydrate Polymers
Volume166
Stato di pubblicazionePublished - 2017

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beta-Cyclodextrins
Hyaluronic acid
Hydrogels
Cyclodextrins
Hyaluronic Acid
Dexamethasone
Derivatives
Ophthalmic Solutions
Pharmaceutical Preparations
Crosslinking
Steroids
Epithelial Cells

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

Cita questo

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title = "Hyaluronic acid and beta cyclodextrins films for the release of corneal epithelial cells and dexamethasone",
abstract = "In this work we prepared hydrogels based on hyaluronic acid and β-cyclodextrins to sustain the release of both corneal epithelial cells and dexamethasone. This steroid is administered as eye drops several times per day to reduce the risk of rejection in the post operative period after the cornea transplantation and cell release techniques. Hydrogels were produced by crosslinking an amino derivative of hyaluronic acid, with the divinyl sulfone derivative of β-cyclodextrins, this last employed as a crosslinker and solubilizing agent. Drug release studies revealed that dexamethasone containing samples are able to extend the release of this drug for at least five days. Biological studies, conducted with human corneal epithelial cells, showed that it is possible to employ the hydrogels for the temporary seeding of the cells and their potential release onto the cornea.",
author = "Palumbo, {Fabio Salvatore} and Calogero Fiorica and Gaetano Giammona and Flavia Bongiov{\`i} and Giovanna Pitarresi and Gaetano Giammona",
year = "2017",
language = "English",
volume = "166",
pages = "281--290",
journal = "Carbohydrate Polymers",
issn = "0144-8617",
publisher = "Elsevier Limited",

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T1 - Hyaluronic acid and beta cyclodextrins films for the release of corneal epithelial cells and dexamethasone

AU - Palumbo, Fabio Salvatore

AU - Fiorica, Calogero

AU - Giammona, Gaetano

AU - Bongiovì, Flavia

AU - Pitarresi, Giovanna

AU - Giammona, Gaetano

PY - 2017

Y1 - 2017

N2 - In this work we prepared hydrogels based on hyaluronic acid and β-cyclodextrins to sustain the release of both corneal epithelial cells and dexamethasone. This steroid is administered as eye drops several times per day to reduce the risk of rejection in the post operative period after the cornea transplantation and cell release techniques. Hydrogels were produced by crosslinking an amino derivative of hyaluronic acid, with the divinyl sulfone derivative of β-cyclodextrins, this last employed as a crosslinker and solubilizing agent. Drug release studies revealed that dexamethasone containing samples are able to extend the release of this drug for at least five days. Biological studies, conducted with human corneal epithelial cells, showed that it is possible to employ the hydrogels for the temporary seeding of the cells and their potential release onto the cornea.

AB - In this work we prepared hydrogels based on hyaluronic acid and β-cyclodextrins to sustain the release of both corneal epithelial cells and dexamethasone. This steroid is administered as eye drops several times per day to reduce the risk of rejection in the post operative period after the cornea transplantation and cell release techniques. Hydrogels were produced by crosslinking an amino derivative of hyaluronic acid, with the divinyl sulfone derivative of β-cyclodextrins, this last employed as a crosslinker and solubilizing agent. Drug release studies revealed that dexamethasone containing samples are able to extend the release of this drug for at least five days. Biological studies, conducted with human corneal epithelial cells, showed that it is possible to employ the hydrogels for the temporary seeding of the cells and their potential release onto the cornea.

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UR - http://www.elsevier.com/wps/find/journaldescription.cws_home/405871/description#description

M3 - Article

VL - 166

SP - 281

EP - 290

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

SN - 0144-8617

ER -