Hyaluronan-coated polybenzofulvene brushes as biomimetic materials

Gaetano Giammona, Mariano Licciardi, Cinzia Scialabba, Salvatore Battiato, Marco Paolino, Giorgio Grisci, Vincenzo Razzano, Salvatore Battiato, Claudia Bonechi, Francesco Makovec, Filippo Samperi, Raniero Mendichi, Alessandro Donati, Andrea Cappelli, Germano Giuliani

Risultato della ricerca: Articlepeer review

16 Citazioni (Scopus)

Abstract

Hyaluronic acid (HA) forms pericellular coats in many cell types that are involved in the early stages of cell adhesion by interacting with the CD44 receptor. Based on the largely recognized overexpression of the CD44 receptor in tumor tissues, a polybenzofulvene molecular brush has been enveloped into hyaluronan shells to obtain a tri-component polymer brush (TCPB) composed of intrinsically fluorescent backbones bearing nona(ethylene glycol) arms terminated with low molecular weight HA macromolecules. The nanoaggregates obtained in TCPB water dispersions were characterized on the basis of dimensions, zeta potential, and in vitro cell toxicity. This biomimetic multifunctional material bearing HA on the surface of its cylindrical brush architecture showed promising prerequisites for the preparation of nanostructured drug delivery systems.
Lingua originaleEnglish
pagine (da-a)6529-6544
Numero di pagine16
RivistaPolymer Chemistry
Volume7
Stato di pubblicazionePublished - 2016

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Polymers and Plastics
  • Organic Chemistry

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