Hyaluronan-coated polybenzofulvene brushes as biomimetic materials

Gaetano Giammona; Mariano Licciardi; Cinzia Scialabba; Salvatore Battiato; Marco Paolino; Giorgio Grisci; Vincenzo Razzano; Salvatore Battiato; Claudia Bonechi; Francesco Makovec; Filippo Samperi; Raniero Mendichi; Alessandro Donati; Andrea Cappelli; Germano Giuliani

Hyaluronan-coated polybenzofulvene brushes as biomimetic materials

Gaetano Giammona, Mariano Licciardi, Cinzia Scialabba, Salvatore Battiato, Marco Paolino, Giorgio Grisci, Vincenzo Razzano, Salvatore Battiato, Claudia Bonechi, Francesco Makovec, Filippo Samperi, Raniero Mendichi, Alessandro Donati, Andrea Cappelli, Germano Giuliani

Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche

Risultato della ricerca: Article › peer review

25 Citazioni (Scopus)

Abstract

Hyaluronic acid (HA) forms pericellular coats in many cell types that are involved in the early stages of cell adhesion by interacting with the CD44 receptor. Based on the largely recognized overexpression of the CD44 receptor in tumor tissues, a polybenzofulvene molecular brush has been enveloped into hyaluronan shells to obtain a tri-component polymer brush (TCPB) composed of intrinsically fluorescent backbones bearing nona(ethylene glycol) arms terminated with low molecular weight HA macromolecules. The nanoaggregates obtained in TCPB water dispersions were characterized on the basis of dimensions, zeta potential, and in vitro cell toxicity. This biomimetic multifunctional material bearing HA on the surface of its cylindrical brush architecture showed promising prerequisites for the preparation of nanostructured drug delivery systems.

Lingua originale	English
pagine (da-a)	6529-6544
Numero di pagine	16
Rivista	Polymer Chemistry
Volume	7
Stato di pubblicazione	Published - 2016

All Science Journal Classification (ASJC) codes

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title = "Hyaluronan-coated polybenzofulvene brushes as biomimetic materials",

abstract = "Hyaluronic acid (HA) forms pericellular coats in many cell types that are involved in the early stages of cell adhesion by interacting with the CD44 receptor. Based on the largely recognized overexpression of the CD44 receptor in tumor tissues, a polybenzofulvene molecular brush has been enveloped into hyaluronan shells to obtain a tri-component polymer brush (TCPB) composed of intrinsically fluorescent backbones bearing nona(ethylene glycol) arms terminated with low molecular weight HA macromolecules. The nanoaggregates obtained in TCPB water dispersions were characterized on the basis of dimensions, zeta potential, and in vitro cell toxicity. This biomimetic multifunctional material bearing HA on the surface of its cylindrical brush architecture showed promising prerequisites for the preparation of nanostructured drug delivery systems.",

author = "Gaetano Giammona and Mariano Licciardi and Cinzia Scialabba and Salvatore Battiato and Marco Paolino and Giorgio Grisci and Vincenzo Razzano and Salvatore Battiato and Claudia Bonechi and Francesco Makovec and Filippo Samperi and Raniero Mendichi and Alessandro Donati and Andrea Cappelli and Germano Giuliani",

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journal = "Polymer Chemistry",

issn = "1759-9954",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Hyaluronan-coated polybenzofulvene brushes as biomimetic materials

AU - Giammona, Gaetano

AU - Licciardi, Mariano

AU - Scialabba, Cinzia

AU - Battiato, Salvatore

AU - Paolino, Marco

AU - Grisci, Giorgio

AU - Razzano, Vincenzo

AU - Battiato, Salvatore

AU - Bonechi, Claudia

AU - Makovec, Francesco

AU - Samperi, Filippo

AU - Mendichi, Raniero

AU - Donati, Alessandro

AU - Cappelli, Andrea

AU - Giuliani, Germano

PY - 2016

Y1 - 2016

N2 - Hyaluronic acid (HA) forms pericellular coats in many cell types that are involved in the early stages of cell adhesion by interacting with the CD44 receptor. Based on the largely recognized overexpression of the CD44 receptor in tumor tissues, a polybenzofulvene molecular brush has been enveloped into hyaluronan shells to obtain a tri-component polymer brush (TCPB) composed of intrinsically fluorescent backbones bearing nona(ethylene glycol) arms terminated with low molecular weight HA macromolecules. The nanoaggregates obtained in TCPB water dispersions were characterized on the basis of dimensions, zeta potential, and in vitro cell toxicity. This biomimetic multifunctional material bearing HA on the surface of its cylindrical brush architecture showed promising prerequisites for the preparation of nanostructured drug delivery systems.

AB - Hyaluronic acid (HA) forms pericellular coats in many cell types that are involved in the early stages of cell adhesion by interacting with the CD44 receptor. Based on the largely recognized overexpression of the CD44 receptor in tumor tissues, a polybenzofulvene molecular brush has been enveloped into hyaluronan shells to obtain a tri-component polymer brush (TCPB) composed of intrinsically fluorescent backbones bearing nona(ethylene glycol) arms terminated with low molecular weight HA macromolecules. The nanoaggregates obtained in TCPB water dispersions were characterized on the basis of dimensions, zeta potential, and in vitro cell toxicity. This biomimetic multifunctional material bearing HA on the surface of its cylindrical brush architecture showed promising prerequisites for the preparation of nanostructured drug delivery systems.

UR - http://hdl.handle.net/10447/225504

UR - http://pubs.rsc.org/en/Journals/JournalIssues/PY

M3 - Article

SN - 1759-9954

VL - 7

SP - 6529

EP - 6544

JO - Polymer Chemistry

JF - Polymer Chemistry

ER -

Hyaluronan-coated polybenzofulvene brushes as biomimetic materials

Abstract

All Science Journal Classification (ASJC) codes

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