Abstract

In the last three decades, the constantly increasing need for therapies,efficiently preventing and/or treating human diseases, has raised the interestin Regenerative Medicine (RM). RM is based on employing mesenchymal stemcells (MSCs), that showed to have great proliferation, self-renewal and multilineagedifferentiation potential, in vitro as well as in vivo. The opportunityof an accessible, painless and low-cost reservoir of MSCs constitutes the firstimportant step of a successful regenerative therapy to include in the currentclinical practice. Oral cavity has recently demonstrated to contain differentMSCs niches: dental pulp from permanent and deciduous teeth, periodontalligament, dental follicle, apical papilla and mucosa. MSCs from dental pulpof deciduous teeth, naturally lost in pediatric age, and the oral mucosa haveshown to be easily harvested and to have a promising regenerative potential.Thus, the aim of the paper is to review the potentialities of human exfoliateddeciduous teeth stem cells (SHEDs) and oral mucosa stem cells (OMSCs) in RM,with the purpose of their use as accessible source of MSCs for the future ofpediatric patient.
Lingua originaleEnglish
pagine (da-a)12-17
Numero di pagine6
RivistaJOURNAL OF PEDIATRICS AND PEDIATRIC MEDICINE
Stato di pubblicazionePublished - 2018

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Regenerative Medicine
Deciduous Tooth
Mouth Mucosa
Regeneration
Tooth
Stem Cells
Dental Sac
Dental Pulp
Mouth
Mucous Membrane
Pediatrics
Costs and Cost Analysis
Therapeutics

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@article{784357ec3cb54fba8efe4896908bb719,
title = "Human exfoliated deciduous teeth and oral mucosa: promising applications in tissue regeneration",
abstract = "In the last three decades, the constantly increasing need for therapies,efficiently preventing and/or treating human diseases, has raised the interestin Regenerative Medicine (RM). RM is based on employing mesenchymal stemcells (MSCs), that showed to have great proliferation, self-renewal and multilineagedifferentiation potential, in vitro as well as in vivo. The opportunityof an accessible, painless and low-cost reservoir of MSCs constitutes the firstimportant step of a successful regenerative therapy to include in the currentclinical practice. Oral cavity has recently demonstrated to contain differentMSCs niches: dental pulp from permanent and deciduous teeth, periodontalligament, dental follicle, apical papilla and mucosa. MSCs from dental pulpof deciduous teeth, naturally lost in pediatric age, and the oral mucosa haveshown to be easily harvested and to have a promising regenerative potential.Thus, the aim of the paper is to review the potentialities of human exfoliateddeciduous teeth stem cells (SHEDs) and oral mucosa stem cells (OMSCs) in RM,with the purpose of their use as accessible source of MSCs for the future ofpediatric patient.",
author = "Carla Giordano and Riccardo Alessandro and Rodolfo Mauceri and Marta Cristaldi and Giuseppina Campisi and Laura Tomasello and Giuseppe Pizzolanti and Giovanni Zito",
year = "2018",
language = "English",
pages = "12--17",
journal = "JOURNAL OF PEDIATRICS AND PEDIATRIC MEDICINE",
issn = "2578-2940",

}

TY - JOUR

T1 - Human exfoliated deciduous teeth and oral mucosa: promising applications in tissue regeneration

AU - Giordano, Carla

AU - Alessandro, Riccardo

AU - Mauceri, Rodolfo

AU - Cristaldi, Marta

AU - Campisi, Giuseppina

AU - Tomasello, Laura

AU - Pizzolanti, Giuseppe

AU - Zito, Giovanni

PY - 2018

Y1 - 2018

N2 - In the last three decades, the constantly increasing need for therapies,efficiently preventing and/or treating human diseases, has raised the interestin Regenerative Medicine (RM). RM is based on employing mesenchymal stemcells (MSCs), that showed to have great proliferation, self-renewal and multilineagedifferentiation potential, in vitro as well as in vivo. The opportunityof an accessible, painless and low-cost reservoir of MSCs constitutes the firstimportant step of a successful regenerative therapy to include in the currentclinical practice. Oral cavity has recently demonstrated to contain differentMSCs niches: dental pulp from permanent and deciduous teeth, periodontalligament, dental follicle, apical papilla and mucosa. MSCs from dental pulpof deciduous teeth, naturally lost in pediatric age, and the oral mucosa haveshown to be easily harvested and to have a promising regenerative potential.Thus, the aim of the paper is to review the potentialities of human exfoliateddeciduous teeth stem cells (SHEDs) and oral mucosa stem cells (OMSCs) in RM,with the purpose of their use as accessible source of MSCs for the future ofpediatric patient.

AB - In the last three decades, the constantly increasing need for therapies,efficiently preventing and/or treating human diseases, has raised the interestin Regenerative Medicine (RM). RM is based on employing mesenchymal stemcells (MSCs), that showed to have great proliferation, self-renewal and multilineagedifferentiation potential, in vitro as well as in vivo. The opportunityof an accessible, painless and low-cost reservoir of MSCs constitutes the firstimportant step of a successful regenerative therapy to include in the currentclinical practice. Oral cavity has recently demonstrated to contain differentMSCs niches: dental pulp from permanent and deciduous teeth, periodontalligament, dental follicle, apical papilla and mucosa. MSCs from dental pulpof deciduous teeth, naturally lost in pediatric age, and the oral mucosa haveshown to be easily harvested and to have a promising regenerative potential.Thus, the aim of the paper is to review the potentialities of human exfoliateddeciduous teeth stem cells (SHEDs) and oral mucosa stem cells (OMSCs) in RM,with the purpose of their use as accessible source of MSCs for the future ofpediatric patient.

UR - http://hdl.handle.net/10447/297300

UR - http://www.pediatricsresearchjournal.com/articles/human-exfoliated-deciduous-teeth-and-oral-mucosa-promising-applications-in-tissue-regeneration.html

M3 - Article

SP - 12

EP - 17

JO - JOURNAL OF PEDIATRICS AND PEDIATRIC MEDICINE

JF - JOURNAL OF PEDIATRICS AND PEDIATRIC MEDICINE

SN - 2578-2940

ER -