Human Drug Pollution in the Aquatic System: The Biochemical Responses of Danio rerio Adults

Luigi Inguglia, Manuela Mauro, Mirella Vazzana, Vincenzo Arizza, Claudio Luparello, Vincenzo Ferrantelli, Gaetano Cammilleri, Valentina Lazzara

Risultato della ricerca: Articlepeer review

5 Citazioni (Scopus)


To date, drug pollution in aquatic systems is an urgent issue, and Danio rerio is a modelorganism to study the toxicological effects of environmental pollutants. The scientific literature hasanalyzed the effect of human drug pollution on the biochemical responses in the tissues of D. rerioadults. However, the information is still scarce and conflicting, making it difficult to understandits real impact. The scientific studies are not consistent with each other and, until now, no onehas grouped their results to create a baseline of knowledge of the possible impacts. In this review,the analysis of literature data highlights that the effects of drugs on adult zebrafishes depend onvarious factors, such as the tissue analyzed, the drug concentration and the sex of the individuals.Furthermore, the most influenced biochemical responses concern enzymes (e.g., antioxidants andhydrolase enzymes) and total protein and hormonal levels. Pinpointing the situation to date wouldimprove the understanding of the chronic effects of human drug pollution, helping both to reduce itin the aquatic systems and then to draw up regulations to control this type of pollution.
Lingua originaleEnglish
pagine (da-a)1-27
Numero di pagine27
Stato di pubblicazionePublished - 2021

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2400.2400???
  • ???subjectarea.asjc.1100.1100???


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