Hsp60: molecular anatomy and role in colorectal cancer diagnosis and treatment

Felicia Farina, Sabrina David, Giovanni Zummo, Francesco Cappello, Giovanni Peri, Everly Conway De Macario, Alberto Jl Macario

Risultato della ricerca: Article

20 Citazioni (Scopus)

Abstract

Quantitative changes in Hsp60 during thedevelopment of some tumors suggest that this chaperonin plays a role in carcinogenesis. A description of the specific role(s) of Hsp60 in tumor-cell growth and proliferation isstill incomplete, but it is already evident that monitoring its levels and distribution in tissues and fluids has potential for diagnosis and staging, and for assessing prognosis and response to treatment. Although Hsp60 is considered an intramitochondrial protein, it has been demonstrated in the cytosol, cell membrane, vesicles, cell surface, extracellular space, and blood. The knowledge that Hsp60 occurs at all these locations opens new avenues for basic and applied research. It is clear that elucidating the mechanisms by which the chaperonin arrives at these various locations, and characterizing its functions in each of them will provide information useful for understanding carcinogenesis and for developing diagnostic and therapeutic tools for clinical oncology. Some of these issues pertinent to colorectal cancer (CRC) are discussed in this article.
Lingua originaleEnglish
pagine (da-a)341-351
Numero di pagine11
RivistaFrontiers in Bioscience
Volume1(3)
Stato di pubblicazionePublished - 2011

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Chaperonins
Tumors
Colorectal Neoplasms
Anatomy
Carcinogenesis
Oncology
Medical Oncology
Cell proliferation
Extracellular Space
Cell growth
Tissue Distribution
Cell membranes
Cytosol
Neoplasms
Blood
Cell Proliferation
Cell Membrane
Tissue
Fluids
Monitoring

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cita questo

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title = "Hsp60: molecular anatomy and role in colorectal cancer diagnosis and treatment",
abstract = "Quantitative changes in Hsp60 during thedevelopment of some tumors suggest that this chaperonin plays a role in carcinogenesis. A description of the specific role(s) of Hsp60 in tumor-cell growth and proliferation isstill incomplete, but it is already evident that monitoring its levels and distribution in tissues and fluids has potential for diagnosis and staging, and for assessing prognosis and response to treatment. Although Hsp60 is considered an intramitochondrial protein, it has been demonstrated in the cytosol, cell membrane, vesicles, cell surface, extracellular space, and blood. The knowledge that Hsp60 occurs at all these locations opens new avenues for basic and applied research. It is clear that elucidating the mechanisms by which the chaperonin arrives at these various locations, and characterizing its functions in each of them will provide information useful for understanding carcinogenesis and for developing diagnostic and therapeutic tools for clinical oncology. Some of these issues pertinent to colorectal cancer (CRC) are discussed in this article.",
keywords = "Chaperoning system, Chaperonology, Chaperonopathies, Chaperonotherapy, Clinical oncology, Colorectal cancer, Hsp60, Review",
author = "Felicia Farina and Sabrina David and Giovanni Zummo and Francesco Cappello and Giovanni Peri and {De Macario}, {Everly Conway} and Macario, {Alberto Jl}",
year = "2011",
language = "English",
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journal = "Frontiers in Bioscience - Landmark",
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TY - JOUR

T1 - Hsp60: molecular anatomy and role in colorectal cancer diagnosis and treatment

AU - Farina, Felicia

AU - David, Sabrina

AU - Zummo, Giovanni

AU - Cappello, Francesco

AU - Peri, Giovanni

AU - De Macario, Everly Conway

AU - Macario, Alberto Jl

PY - 2011

Y1 - 2011

N2 - Quantitative changes in Hsp60 during thedevelopment of some tumors suggest that this chaperonin plays a role in carcinogenesis. A description of the specific role(s) of Hsp60 in tumor-cell growth and proliferation isstill incomplete, but it is already evident that monitoring its levels and distribution in tissues and fluids has potential for diagnosis and staging, and for assessing prognosis and response to treatment. Although Hsp60 is considered an intramitochondrial protein, it has been demonstrated in the cytosol, cell membrane, vesicles, cell surface, extracellular space, and blood. The knowledge that Hsp60 occurs at all these locations opens new avenues for basic and applied research. It is clear that elucidating the mechanisms by which the chaperonin arrives at these various locations, and characterizing its functions in each of them will provide information useful for understanding carcinogenesis and for developing diagnostic and therapeutic tools for clinical oncology. Some of these issues pertinent to colorectal cancer (CRC) are discussed in this article.

AB - Quantitative changes in Hsp60 during thedevelopment of some tumors suggest that this chaperonin plays a role in carcinogenesis. A description of the specific role(s) of Hsp60 in tumor-cell growth and proliferation isstill incomplete, but it is already evident that monitoring its levels and distribution in tissues and fluids has potential for diagnosis and staging, and for assessing prognosis and response to treatment. Although Hsp60 is considered an intramitochondrial protein, it has been demonstrated in the cytosol, cell membrane, vesicles, cell surface, extracellular space, and blood. The knowledge that Hsp60 occurs at all these locations opens new avenues for basic and applied research. It is clear that elucidating the mechanisms by which the chaperonin arrives at these various locations, and characterizing its functions in each of them will provide information useful for understanding carcinogenesis and for developing diagnostic and therapeutic tools for clinical oncology. Some of these issues pertinent to colorectal cancer (CRC) are discussed in this article.

KW - Chaperoning system

KW - Chaperonology

KW - Chaperonopathies

KW - Chaperonotherapy

KW - Clinical oncology

KW - Colorectal cancer

KW - Hsp60

KW - Review

UR - http://hdl.handle.net/10447/55570

M3 - Article

VL - 1(3)

SP - 341

EP - 351

JO - Frontiers in Bioscience - Landmark

JF - Frontiers in Bioscience - Landmark

SN - 1093-9946

ER -