HSP60 is a ubiquitous player in the physiological and pathogenic interactions between the chaperoning and the immune systems

Celeste Caruso Bavisotto, Claudia Campanella, Antonella Marino Gammazza, Francesca Rappa, Francesco Cappello, Sabrina David, Rosario Barone, Claudia Campanella, Antonella Marino Gammazza, Rosario Barone, Francesca Rappa, Celeste Caruso Bavisotto, Everly Conway De Macario, Francesco Cappello, Alberto J. L. Macario

Risultato della ricerca: Article

3 Citazioni (Scopus)

Abstract

HSP60 participates in many interactions between the system integrated by all chaperones and closely associated molecules (chaperoning system or CS) and the immune system (IS). These interactions occur constantly to maintain normal cell physiology but, occasionally, they are perturbed and become mediators of pathologic events that may lead to disease. This switch to pathology may be initiated by various factors, genetic or acquired, which cause qualitative and/or quantitative modifications of HSP60, or immune crossreactivity between the human and microbial chaperonin orthologs, or a break in the balance between the pro- and anti-inflammatory actions of the chaperonin. Thus, autoimmune and chronic inflammatory pathologies may occur. Likewise, a perturbation of the CS-IS interactions, e.g., those that take place during ageing, may favor carcinogenesis. HSP60 may be commandeered by tumor cells to assist its high-rate protein synthesis and, also, to be an emissary among the devices tumor cells utilize to avoid anti-tumor immune reactions. Here, we briefly discuss the canonical and non-canonical functions of HSP/chaperones; and HSP60 as a multifunctional molecule, its migration itinerary, and its possible roles during carcinogenesis and in certain chronic inflammatory and autoimmune diseases. We examine the potential of HSP60 as a biomarker useful for diagnosing and monitoring the progression of the various conditions in which it actively participates. Lastly, we discuss the use HSP60 as target for controlling its activity when it is an etiopathogenic factor, or as a therapeutic agent to correct its deficiency.
Lingua originaleEnglish
pagine (da-a)44-55
Numero di pagine12
RivistaCURRENT IMMUNOLOGY REVIEW
Volume13
Stato di pubblicazionePublished - 2017

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Chaperonins
Immune System
Carcinogenesis
Pathology
Cell Physiological Phenomena
Neoplasms
Autoimmune Diseases
Chronic Disease
Anti-Inflammatory Agents
Biomarkers
Equipment and Supplies
Proteins
Therapeutics

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cita questo

HSP60 is a ubiquitous player in the physiological and pathogenic interactions between the chaperoning and the immune systems. / Caruso Bavisotto, Celeste; Campanella, Claudia; Marino Gammazza, Antonella; Rappa, Francesca; Cappello, Francesco; David, Sabrina; Barone, Rosario; Campanella, Claudia; Gammazza, Antonella Marino; Barone, Rosario; Rappa, Francesca; Bavisotto, Celeste Caruso; De Macario, Everly Conway; Cappello, Francesco; Macario, Alberto J. L.

In: CURRENT IMMUNOLOGY REVIEW, Vol. 13, 2017, pag. 44-55.

Risultato della ricerca: Article

Caruso Bavisotto, Celeste ; Campanella, Claudia ; Marino Gammazza, Antonella ; Rappa, Francesca ; Cappello, Francesco ; David, Sabrina ; Barone, Rosario ; Campanella, Claudia ; Gammazza, Antonella Marino ; Barone, Rosario ; Rappa, Francesca ; Bavisotto, Celeste Caruso ; De Macario, Everly Conway ; Cappello, Francesco ; Macario, Alberto J. L. / HSP60 is a ubiquitous player in the physiological and pathogenic interactions between the chaperoning and the immune systems. In: CURRENT IMMUNOLOGY REVIEW. 2017 ; Vol. 13. pagg. 44-55.
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abstract = "HSP60 participates in many interactions between the system integrated by all chaperones and closely associated molecules (chaperoning system or CS) and the immune system (IS). These interactions occur constantly to maintain normal cell physiology but, occasionally, they are perturbed and become mediators of pathologic events that may lead to disease. This switch to pathology may be initiated by various factors, genetic or acquired, which cause qualitative and/or quantitative modifications of HSP60, or immune crossreactivity between the human and microbial chaperonin orthologs, or a break in the balance between the pro- and anti-inflammatory actions of the chaperonin. Thus, autoimmune and chronic inflammatory pathologies may occur. Likewise, a perturbation of the CS-IS interactions, e.g., those that take place during ageing, may favor carcinogenesis. HSP60 may be commandeered by tumor cells to assist its high-rate protein synthesis and, also, to be an emissary among the devices tumor cells utilize to avoid anti-tumor immune reactions. Here, we briefly discuss the canonical and non-canonical functions of HSP/chaperones; and HSP60 as a multifunctional molecule, its migration itinerary, and its possible roles during carcinogenesis and in certain chronic inflammatory and autoimmune diseases. We examine the potential of HSP60 as a biomarker useful for diagnosing and monitoring the progression of the various conditions in which it actively participates. Lastly, we discuss the use HSP60 as target for controlling its activity when it is an etiopathogenic factor, or as a therapeutic agent to correct its deficiency.",
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T1 - HSP60 is a ubiquitous player in the physiological and pathogenic interactions between the chaperoning and the immune systems

AU - Caruso Bavisotto, Celeste

AU - Campanella, Claudia

AU - Marino Gammazza, Antonella

AU - Rappa, Francesca

AU - Cappello, Francesco

AU - David, Sabrina

AU - Barone, Rosario

AU - Campanella, Claudia

AU - Gammazza, Antonella Marino

AU - Barone, Rosario

AU - Rappa, Francesca

AU - Bavisotto, Celeste Caruso

AU - De Macario, Everly Conway

AU - Cappello, Francesco

AU - Macario, Alberto J. L.

PY - 2017

Y1 - 2017

N2 - HSP60 participates in many interactions between the system integrated by all chaperones and closely associated molecules (chaperoning system or CS) and the immune system (IS). These interactions occur constantly to maintain normal cell physiology but, occasionally, they are perturbed and become mediators of pathologic events that may lead to disease. This switch to pathology may be initiated by various factors, genetic or acquired, which cause qualitative and/or quantitative modifications of HSP60, or immune crossreactivity between the human and microbial chaperonin orthologs, or a break in the balance between the pro- and anti-inflammatory actions of the chaperonin. Thus, autoimmune and chronic inflammatory pathologies may occur. Likewise, a perturbation of the CS-IS interactions, e.g., those that take place during ageing, may favor carcinogenesis. HSP60 may be commandeered by tumor cells to assist its high-rate protein synthesis and, also, to be an emissary among the devices tumor cells utilize to avoid anti-tumor immune reactions. Here, we briefly discuss the canonical and non-canonical functions of HSP/chaperones; and HSP60 as a multifunctional molecule, its migration itinerary, and its possible roles during carcinogenesis and in certain chronic inflammatory and autoimmune diseases. We examine the potential of HSP60 as a biomarker useful for diagnosing and monitoring the progression of the various conditions in which it actively participates. Lastly, we discuss the use HSP60 as target for controlling its activity when it is an etiopathogenic factor, or as a therapeutic agent to correct its deficiency.

AB - HSP60 participates in many interactions between the system integrated by all chaperones and closely associated molecules (chaperoning system or CS) and the immune system (IS). These interactions occur constantly to maintain normal cell physiology but, occasionally, they are perturbed and become mediators of pathologic events that may lead to disease. This switch to pathology may be initiated by various factors, genetic or acquired, which cause qualitative and/or quantitative modifications of HSP60, or immune crossreactivity between the human and microbial chaperonin orthologs, or a break in the balance between the pro- and anti-inflammatory actions of the chaperonin. Thus, autoimmune and chronic inflammatory pathologies may occur. Likewise, a perturbation of the CS-IS interactions, e.g., those that take place during ageing, may favor carcinogenesis. HSP60 may be commandeered by tumor cells to assist its high-rate protein synthesis and, also, to be an emissary among the devices tumor cells utilize to avoid anti-tumor immune reactions. Here, we briefly discuss the canonical and non-canonical functions of HSP/chaperones; and HSP60 as a multifunctional molecule, its migration itinerary, and its possible roles during carcinogenesis and in certain chronic inflammatory and autoimmune diseases. We examine the potential of HSP60 as a biomarker useful for diagnosing and monitoring the progression of the various conditions in which it actively participates. Lastly, we discuss the use HSP60 as target for controlling its activity when it is an etiopathogenic factor, or as a therapeutic agent to correct its deficiency.

KW - Autoimmunity

KW - Cancer

KW - Chaperoning system

KW - Exosomes

KW - HSP60

KW - Immune system

KW - Immunology

KW - Immunology and Allergy

KW - Inflammation

UR - http://hdl.handle.net/10447/353453

UR - http://www.benthamdirect.org/pages/all_b_bypublication.php

M3 - Article

VL - 13

SP - 44

EP - 55

JO - Current Immunology Reviews

JF - Current Immunology Reviews

SN - 1573-3955

ER -