The implication of Hsp60 in cancer development is due to its participationin many metabolic and biomolecular mechanisms in cancer cells. Hsp60 interactswith various molecules that are responsible of apoptosis, cell proliferation andother mechanisms involved when a normal cell becomes malignant. Hsp60 expressionwas found to be increased in many types of cancer but in same tumors of differentanatomical district was found decreased. The mechanism of action of Hsp60is different depending on the type of tumor. Its involvement in the carcinogeneticprocess of some tumors, such as large bowel carcinoma or cervical carcinoma,seems to occur in the very early stages of disease. Hsp60 participates in the mechanismof modulation of the immune response the cancer cells use to invade surroundingtissues, and expand the tumor mass.
|Titolo della pubblicazione ospite||Heat Shock Protein 60 in human disease and disorders : Hsp60 Involvement During Carcinogenesis|
|Numero di pagine||9|
|Stato di pubblicazione||Published - 2019|