Hsp60 as a Novel Target in IBD Management: A Prospect

Fabio Bucchieri, Francesco Cappello, Giuseppe Bonaventura, Francesco Carini, Marie Noel Zeenny, Angelo Leone, Giovanni Tomasello, Rosalyn Jurjus, Marie-Noel Zeenny, Abdo Jurjus, Everly Conway De Macario, Francesco Cappello, Alberto J.L. Macario

Risultato della ricerca: Article

2 Citazioni (Scopus)

Abstract

Inflammatory bowel disease (IBD) encompasses various pathological conditions similar but distinct that share a multifactorial etiology, including involvement of the intestinal barrier function, the immune system, and intestinal microorganisms. Hsp60 is a chaperonin component of the chaperoning system, present in all cells and tissues, including the intestine. It plays important roles in cell physiology outside and inside mitochondria, its canonical place of residence. However, Hsp60 can also be pathogenic in many conditions, the Hsp60 chaperonopathies, possibly including IBD. The various clinico-pathological types of IBD have a complicated mix of causative factors, among which Hsp60 can be considered a putatively important driver of events and could play an etiopathogenic role. This possibility is discussed in this review. We also indicate that Hsp60 can be a biomarker useful in disease diagnosing and monitoring and, if found active in pathogenesis, should become a target for developing new therapies. The latter are particularly needed to alleviate patient suffering and to prevent complications, including colon cancer.
Lingua originaleEnglish
pagine (da-a)26-
Numero di pagine8
RivistaDefault journal
Volume10
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cita questo

Hsp60 as a Novel Target in IBD Management: A Prospect. / Bucchieri, Fabio; Cappello, Francesco; Bonaventura, Giuseppe; Carini, Francesco; Zeenny, Marie Noel; Leone, Angelo; Tomasello, Giovanni; Jurjus, Rosalyn; Zeenny, Marie-Noel; Jurjus, Abdo; De Macario, Everly Conway; Cappello, Francesco; Macario, Alberto J.L.

In: Default journal, Vol. 10, 2019, pag. 26-.

Risultato della ricerca: Article

Bucchieri, F, Cappello, F, Bonaventura, G, Carini, F, Zeenny, MN, Leone, A, Tomasello, G, Jurjus, R, Zeenny, M-N, Jurjus, A, De Macario, EC, Cappello, F & Macario, AJL 2019, 'Hsp60 as a Novel Target in IBD Management: A Prospect', Default journal, vol. 10, pagg. 26-.
Bucchieri, Fabio ; Cappello, Francesco ; Bonaventura, Giuseppe ; Carini, Francesco ; Zeenny, Marie Noel ; Leone, Angelo ; Tomasello, Giovanni ; Jurjus, Rosalyn ; Zeenny, Marie-Noel ; Jurjus, Abdo ; De Macario, Everly Conway ; Cappello, Francesco ; Macario, Alberto J.L. / Hsp60 as a Novel Target in IBD Management: A Prospect. In: Default journal. 2019 ; Vol. 10. pagg. 26-.
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abstract = "Inflammatory bowel disease (IBD) encompasses various pathological conditions similar but distinct that share a multifactorial etiology, including involvement of the intestinal barrier function, the immune system, and intestinal microorganisms. Hsp60 is a chaperonin component of the chaperoning system, present in all cells and tissues, including the intestine. It plays important roles in cell physiology outside and inside mitochondria, its canonical place of residence. However, Hsp60 can also be pathogenic in many conditions, the Hsp60 chaperonopathies, possibly including IBD. The various clinico-pathological types of IBD have a complicated mix of causative factors, among which Hsp60 can be considered a putatively important driver of events and could play an etiopathogenic role. This possibility is discussed in this review. We also indicate that Hsp60 can be a biomarker useful in disease diagnosing and monitoring and, if found active in pathogenesis, should become a target for developing new therapies. The latter are particularly needed to alleviate patient suffering and to prevent complications, including colon cancer.",
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T1 - Hsp60 as a Novel Target in IBD Management: A Prospect

AU - Bucchieri, Fabio

AU - Cappello, Francesco

AU - Bonaventura, Giuseppe

AU - Carini, Francesco

AU - Zeenny, Marie Noel

AU - Leone, Angelo

AU - Tomasello, Giovanni

AU - Jurjus, Rosalyn

AU - Zeenny, Marie-Noel

AU - Jurjus, Abdo

AU - De Macario, Everly Conway

AU - Cappello, Francesco

AU - Macario, Alberto J.L.

PY - 2019

Y1 - 2019

N2 - Inflammatory bowel disease (IBD) encompasses various pathological conditions similar but distinct that share a multifactorial etiology, including involvement of the intestinal barrier function, the immune system, and intestinal microorganisms. Hsp60 is a chaperonin component of the chaperoning system, present in all cells and tissues, including the intestine. It plays important roles in cell physiology outside and inside mitochondria, its canonical place of residence. However, Hsp60 can also be pathogenic in many conditions, the Hsp60 chaperonopathies, possibly including IBD. The various clinico-pathological types of IBD have a complicated mix of causative factors, among which Hsp60 can be considered a putatively important driver of events and could play an etiopathogenic role. This possibility is discussed in this review. We also indicate that Hsp60 can be a biomarker useful in disease diagnosing and monitoring and, if found active in pathogenesis, should become a target for developing new therapies. The latter are particularly needed to alleviate patient suffering and to prevent complications, including colon cancer.

AB - Inflammatory bowel disease (IBD) encompasses various pathological conditions similar but distinct that share a multifactorial etiology, including involvement of the intestinal barrier function, the immune system, and intestinal microorganisms. Hsp60 is a chaperonin component of the chaperoning system, present in all cells and tissues, including the intestine. It plays important roles in cell physiology outside and inside mitochondria, its canonical place of residence. However, Hsp60 can also be pathogenic in many conditions, the Hsp60 chaperonopathies, possibly including IBD. The various clinico-pathological types of IBD have a complicated mix of causative factors, among which Hsp60 can be considered a putatively important driver of events and could play an etiopathogenic role. This possibility is discussed in this review. We also indicate that Hsp60 can be a biomarker useful in disease diagnosing and monitoring and, if found active in pathogenesis, should become a target for developing new therapies. The latter are particularly needed to alleviate patient suffering and to prevent complications, including colon cancer.

KW - Hsp60

KW - chaperoning system

KW - chaperonopathy

KW - chaperonotherapy

KW - immune system

KW - inflammatory bowel disease

KW - intestinal wall

KW - microbiota

UR - http://hdl.handle.net/10447/350681

M3 - Article

VL - 10

SP - 26-

JO - Default journal

JF - Default journal

ER -