Abstract
| Lingua originale | English |
|---|---|
| pagine (da-a) | 210-214 |
| Numero di pagine | 5 |
| Rivista | Default journal |
| Volume | 55 |
| Stato di pubblicazione | Published - 2011 |
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All Science Journal Classification (ASJC) codes
- Biophysics
- Histology
- Cell Biology
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HSP10,HSP70 AND HSP90 IMMUNOHISTOCHEMICAL LEVELS CHANGE IN ULCERATIVE COLITIS AFTER THERAPY. / Rappa, Francesca; Tomasello, Giovanni; Zerilli, Monica; Sciume', Carmelo; Farina, Felicia; De Luca, Rossella; Cappello, Francesco; Martorana, Anna; Zummo, Giovanni; Rodolico, Vito; Romeo, Marcello; Cicero, Giuseppe; Modica, Giuseppe; Bonaventura, Giuseppe; Romeo; Cappello; Conway De Macario; Macario, Alberto J.L.
In: Default journal, Vol. 55, 2011, pag. 210-214.Risultato della ricerca: Article
}
TY - JOUR
T1 - HSP10,HSP70 AND HSP90 IMMUNOHISTOCHEMICAL LEVELS CHANGE IN ULCERATIVE COLITIS AFTER THERAPY
AU - Rappa, Francesca
AU - Tomasello, Giovanni
AU - Zerilli, Monica
AU - Sciume', Carmelo
AU - Farina, Felicia
AU - De Luca, Rossella
AU - Cappello, Francesco
AU - Martorana, Anna
AU - Zummo, Giovanni
AU - Rodolico, Vito
AU - Romeo, Marcello
AU - Cicero, Giuseppe
AU - Modica, Giuseppe
AU - Bonaventura, Giuseppe
AU - Romeo, null
AU - Cappello, null
AU - Conway De Macario, null
AU - Macario, Alberto J.L.
PY - 2011
Y1 - 2011
N2 - Ulcerative Colitis (UC) is a form of inflammatory bowel disease (IBD) characterized by damage of large bowel mucosa and frequent extra-intestinal autoimmune comorbidities. The role played in IBD pathogenesis by molecular chaperones known to interact with components of the immune system involved in inflammation is unclear. We previously demonstrated that mucosal HSP60 decreases in UC patients treated with conventional therapies (mesalazine, probiotics), suggesting that this chaperonin could be a reliable biomarker useful for monitoring response to treatment, and that it might play a role in pathogenesis. In the present work we investigated three other heat sock protein/molecular chaperones:HSP10, HSP70; and HSP90. We found that the levels of these proteins are increased in UC patients at the time of diagnosis and decrease after therapy, supporting the notion that these proteins deserve attention in the study of the mechanism that promote the development and maintenance of IBD, and as biomarkers of this disease (c.g., to monitor response to treatment at the histological level).
AB - Ulcerative Colitis (UC) is a form of inflammatory bowel disease (IBD) characterized by damage of large bowel mucosa and frequent extra-intestinal autoimmune comorbidities. The role played in IBD pathogenesis by molecular chaperones known to interact with components of the immune system involved in inflammation is unclear. We previously demonstrated that mucosal HSP60 decreases in UC patients treated with conventional therapies (mesalazine, probiotics), suggesting that this chaperonin could be a reliable biomarker useful for monitoring response to treatment, and that it might play a role in pathogenesis. In the present work we investigated three other heat sock protein/molecular chaperones:HSP10, HSP70; and HSP90. We found that the levels of these proteins are increased in UC patients at the time of diagnosis and decrease after therapy, supporting the notion that these proteins deserve attention in the study of the mechanism that promote the development and maintenance of IBD, and as biomarkers of this disease (c.g., to monitor response to treatment at the histological level).
UR - http://hdl.handle.net/10447/62452
M3 - Article
VL - 55
SP - 210
EP - 214
JO - Default journal
JF - Default journal
ER -