Hsp10: anatomic distribution, functions, and involvement in human disease.

Fabio Bucchieri, Mario Giuffre, Sabrina David, Giampiero La Rocca, Rita Anzalone, Giovanni Zummo, Giovanni Peri, Francesco Cappello, Claudia Campanella, Felicia Farina, Giuseppe Modica, Giovanni Tomasello, Carmelo Sciume', Claudia Campanella, Simona Corrao, Giampiero La Rocca, Anna M. Czarnecka, Fabio Bucchieri, Everly Conway De Macario, Francesco CappelloAlberto J.L. Macario, Simona Corrao

Risultato della ricerca: Article

22 Citazioni (Scopus)

Abstract

There is growing evidence that molecular chaperones/heat shock proteins are involved in the pathogenesis of a number of human diseases, known as chaperonopathies. A better molecular understanding of the pathogenetic mechanisms is essential for addressing new strategies in diagnostics, therapeutics and clinical management of chaperonopathies, including those in which Hsp10 is involved. This chaperonin has been studied for a long time as a member of the mitochondrial protein-folding machine. However, although in normal cells Hsp10 is mainly localized in the mitochondrial matrix, it has also been found during and after stress in other subcellular compartments, such as cytosol, vesicles and secretory granules, alone or in combination with other proteins. In these extramitochondrial locales, Hsp10 plays an active role in cell signalling. For example, cancer cells often show altered levels of Hsp10, compared to normal cells. Hsp10 may also be found in the extracellular space and in the bloodstream, with a possible immunomodulatory activity. This minireview focuses on some studies to date on the involvement of Hsp10 in human disease pathogenesis.
Lingua originaleEnglish
pagine (da-a)768-778
Numero di pagine11
RivistaFRONTIERS IN BIOSCIENCE
Volume5
Stato di pubblicazionePublished - 2013

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Distribution functions
Chaperonins
Cell signaling
Protein folding
Molecular Chaperones
Mitochondrial Proteins
Heat-Shock Proteins
Cells
Protein Folding
Secretory Vesicles
Extracellular Space
Cytosol
Proteins
Neoplasms
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cita questo

Hsp10: anatomic distribution, functions, and involvement in human disease. / Bucchieri, Fabio; Giuffre, Mario; David, Sabrina; La Rocca, Giampiero; Anzalone, Rita; Zummo, Giovanni; Peri, Giovanni; Cappello, Francesco; Campanella, Claudia; Farina, Felicia; Modica, Giuseppe; Tomasello, Giovanni; Sciume', Carmelo; Campanella, Claudia; Corrao, Simona; La Rocca, Giampiero; Czarnecka, Anna M.; Bucchieri, Fabio; De Macario, Everly Conway; Cappello, Francesco; Macario, Alberto J.L.; Corrao, Simona.

In: FRONTIERS IN BIOSCIENCE, Vol. 5, 2013, pag. 768-778.

Risultato della ricerca: Article

Bucchieri, Fabio ; Giuffre, Mario ; David, Sabrina ; La Rocca, Giampiero ; Anzalone, Rita ; Zummo, Giovanni ; Peri, Giovanni ; Cappello, Francesco ; Campanella, Claudia ; Farina, Felicia ; Modica, Giuseppe ; Tomasello, Giovanni ; Sciume', Carmelo ; Campanella, Claudia ; Corrao, Simona ; La Rocca, Giampiero ; Czarnecka, Anna M. ; Bucchieri, Fabio ; De Macario, Everly Conway ; Cappello, Francesco ; Macario, Alberto J.L. ; Corrao, Simona. / Hsp10: anatomic distribution, functions, and involvement in human disease. In: FRONTIERS IN BIOSCIENCE. 2013 ; Vol. 5. pagg. 768-778.
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AU - Bucchieri, Fabio

AU - Giuffre, Mario

AU - David, Sabrina

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AU - Anzalone, Rita

AU - Zummo, Giovanni

AU - Peri, Giovanni

AU - Cappello, Francesco

AU - Campanella, Claudia

AU - Farina, Felicia

AU - Modica, Giuseppe

AU - Tomasello, Giovanni

AU - Sciume', Carmelo

AU - Campanella, Claudia

AU - Corrao, Simona

AU - La Rocca, Giampiero

AU - Czarnecka, Anna M.

AU - Bucchieri, Fabio

AU - De Macario, Everly Conway

AU - Cappello, Francesco

AU - Macario, Alberto J.L.

AU - Corrao, Simona

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