HSP-MOLECULAR CHAPERONES IN CANCER BIOGENESIS AND TUMOR THERAPY: AN OVERVIEW

Sabrina David, Giovanni Zummo, Felicia Farina, Giovanni Tomasello, Claudia Campanella, Francesco Carini, Francesca Rappa, Francesco Cappello, Claudia Campanella, Francesca Rappa, Everly Conway De Macario, Francesco Cappello, Alberto J. L. Macario

Risultato della ricerca: Article

73 Citazioni (Scopus)

Abstract

Molecular chaperones, many of which are heat-shock proteins (HSPs), are an important class of molecules with various functions. Pathological conditions in which chaperones become etiological and/or pathogenic factors are called chaperonopathies, and are classified into by defect, by excess, and by "mistake". In the latter case, the chaperone is structurally and functionally normal but paqrtecipates in pathwais that favor diseases, aòlthough in some cases the chaperone may have post-translational modifications that may lead it to change its location and function and, thus, to become pathogenic. For example, HSP-chaperones are involved in acrcinogenesis in various ways, so that some forms of cancer may be considered "chaperonopathies by mistake". This concept suggests new strategies for anticancer therapy (chaperonotherapy), in which the primary targets or therapeutic agents are choaperones. Chaperonotherapy consists of the utilization of HSP-chaperones for treating chaperonopathies, including cancer. Negative chaperonotherapy is aimed at eliminating or blocking the action of chaperones that favour carcinogenesis or other diseases, whereas positive chaperonotherapy uses chaperones, genes or proteins, to gight against dioseases, such cancer, by stimulating the immune system or the cellular defences against stress.
Lingua originaleEnglish
pagine (da-a)5139-5150
Numero di pagine12
RivistaAnticancer Research
Volume32
Stato di pubblicazionePublished - 2012

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Molecular Chaperones
Heat-Shock Proteins
Neoplasms
Post Translational Protein Processing
Immune System
Carcinogenesis
Therapeutics
Proteins

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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HSP-MOLECULAR CHAPERONES IN CANCER BIOGENESIS AND TUMOR THERAPY: AN OVERVIEW. / David, Sabrina; Zummo, Giovanni; Farina, Felicia; Tomasello, Giovanni; Campanella, Claudia; Carini, Francesco; Rappa, Francesca; Cappello, Francesco; Campanella, Claudia; Rappa, Francesca; De Macario, Everly Conway; Cappello, Francesco; Macario, Alberto J. L.

In: Anticancer Research, Vol. 32, 2012, pag. 5139-5150.

Risultato della ricerca: Article

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abstract = "Molecular chaperones, many of which are heat-shock proteins (HSPs), are an important class of molecules with various functions. Pathological conditions in which chaperones become etiological and/or pathogenic factors are called chaperonopathies, and are classified into by defect, by excess, and by {"}mistake{"}. In the latter case, the chaperone is structurally and functionally normal but paqrtecipates in pathwais that favor diseases, a{\`o}lthough in some cases the chaperone may have post-translational modifications that may lead it to change its location and function and, thus, to become pathogenic. For example, HSP-chaperones are involved in acrcinogenesis in various ways, so that some forms of cancer may be considered {"}chaperonopathies by mistake{"}. This concept suggests new strategies for anticancer therapy (chaperonotherapy), in which the primary targets or therapeutic agents are choaperones. Chaperonotherapy consists of the utilization of HSP-chaperones for treating chaperonopathies, including cancer. Negative chaperonotherapy is aimed at eliminating or blocking the action of chaperones that favour carcinogenesis or other diseases, whereas positive chaperonotherapy uses chaperones, genes or proteins, to gight against dioseases, such cancer, by stimulating the immune system or the cellular defences against stress.",
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T1 - HSP-MOLECULAR CHAPERONES IN CANCER BIOGENESIS AND TUMOR THERAPY: AN OVERVIEW

AU - David, Sabrina

AU - Zummo, Giovanni

AU - Farina, Felicia

AU - Tomasello, Giovanni

AU - Campanella, Claudia

AU - Carini, Francesco

AU - Rappa, Francesca

AU - Cappello, Francesco

AU - Campanella, Claudia

AU - Rappa, Francesca

AU - De Macario, Everly Conway

AU - Cappello, Francesco

AU - Macario, Alberto J. L.

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AB - Molecular chaperones, many of which are heat-shock proteins (HSPs), are an important class of molecules with various functions. Pathological conditions in which chaperones become etiological and/or pathogenic factors are called chaperonopathies, and are classified into by defect, by excess, and by "mistake". In the latter case, the chaperone is structurally and functionally normal but paqrtecipates in pathwais that favor diseases, aòlthough in some cases the chaperone may have post-translational modifications that may lead it to change its location and function and, thus, to become pathogenic. For example, HSP-chaperones are involved in acrcinogenesis in various ways, so that some forms of cancer may be considered "chaperonopathies by mistake". This concept suggests new strategies for anticancer therapy (chaperonotherapy), in which the primary targets or therapeutic agents are choaperones. Chaperonotherapy consists of the utilization of HSP-chaperones for treating chaperonopathies, including cancer. Negative chaperonotherapy is aimed at eliminating or blocking the action of chaperones that favour carcinogenesis or other diseases, whereas positive chaperonotherapy uses chaperones, genes or proteins, to gight against dioseases, such cancer, by stimulating the immune system or the cellular defences against stress.

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