How radical prostatectomy procedures have changed over the last 10 years in Italy: a comparative analysis based on more than 1500 patients participating in the MIRROR-SIU/LUNA and the Pros-IT CNR study

Alchiede Simonato, Luisa Rossini, Darvinio Melloni, Elena Castelli, Francesco Antonio Lembo, Vito Gentile, Andrea Giacobbe, Anna Maria Sciarra, Annunziata Briganti, Antonella Antonelli, Antonino Volpe, Chiara Guida, Dario Tomasini, Federica Antonia Celia, Ferdinando Fusco, Gabriele Grosso, Giovanni Francolini, Giulia Frezza, Giuseppa Di Nicola, Giuseppe BianchiGiuseppe Pomara, Isabella Ferrari, Luigi Miano, Luigi Filippo Cortese, Manfredi De Angelis, Mario Motta, Sergio Di Meo, Tommaso Brancato, Vincenzo Zaccone, Vito Giovanni Silvano

Risultato della ricerca: Articlepeer review

Abstract

Purpose: Therapeutic strategies for prostate cancer (PCa) have been evolving dramatically worldwide. The current article reports on the evolution of surgical management strategies for PCa in Italy. Methods: The data from two independent Italian multicenter projects, the MIRROR-SIU/LUNA (started in 2007, holding data of 890 patients) and the Pros-IT-CNR project (started in 2014, with data of 692 patients), were compared. Differences in patients’ characteristics were evaluated. Multivariable logistic regression models were used to identify characteristics associated with robot-assisted (RA) procedure, nerve sparing (NS) approach, and lymph node dissection (LND). Results: The two cohorts did not differ in terms of age and prostate-specific antigen (PSA) levels at biopsy. Patients enrolled in the Pros-IT-CNR project more frequently were submitted to RA (58.8% vs 27.6%, p < 0.001) and NS prostatectomy (58.4% vs. 52.9%, p = 0.04), but received LND less frequently (47.7% vs. 76.7%, p < 0.001), as compared to the MIRROR-SIU/LUNA patients. At multivariate logistic models, Lower Gleason Scores (GS) and PSA levels were significantly associated with RA prostatectomy in both cohorts. As for the MIRROR-SIU/LUNA data, clinical T-stage was a predictor for NS (OR = 0.07 for T3, T4) and LND (OR = 2.41 for T2) procedures. As for Pros-IT CNR data, GS ≥ (4 + 3) and positive cancer cores ≥ 50% were decisive factors both for NS (OR 0.29 and 0.30) and LND (OR 7.53 and 2.31) strategies. Conclusions: PCa management has changed over the last decade in Italian centers: RA and NS procedures without LND have become the methods of choice to treat newly medium–high risk diagnosed PCa.
Lingua originaleEnglish
pagine (da-a)1-8
Numero di pagine8
RivistaWorld Journal of Urology
Stato di pubblicazionePublished - 2020

All Science Journal Classification (ASJC) codes

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