How Effective and Safe Is Bronchial Thermoplasty in "real Life" Asthmatics Compared to Those Enrolled in Randomized Clinical Trials?

Nicola Scichilone, Alida Benfante, Salvatore Battaglia, Alba La Sala, Alba La Sala, Carla Galeone, Giuseppe Failla, Nicola Facciolongo, Rita Arrigo

Risultato della ricerca: Articlepeer review

4 Citazioni (Scopus)

Abstract

There is limited information on the efficacy and safety of bronchial thermoplasty (BT) in real life. We evaluated the outcomes of the randomized clinical trials for BT in severe asthmatics, in whom the exclusion criteria were not strictly controlled. A case series of seven asthmatics (M/F: 4/3; age: 54.6 ± 2.9 years) is reported. Subjects had a statistically significant improvement in AQLQ (from a mean of 3.96 ± 1.1 to 4.5 ± 1.2 and 5.5 ± 0.6 after 6 and 12 months of treatment; p = 0.0007) and in the ACQ score (from 2.77 ± 0.8 to 1.83 ± 1.2 and 1.5 ± 0.8 after 6 and 12 months; p < 0.001). In the year after BT, severe exacerbations, salbutamol use, and OCS use were significantly lower compared with the 1-yr pretreatment period (p < 0.001). No ED visits and hospitalization occurred in the year after BT. No changes in functional parameters were recorded. Our investigation confirms the safety and efficacy of BT in severe asthmatics in real life settings.
Lingua originaleEnglish
Numero di pagine0
RivistaBioMed Research International
Volume2016
Stato di pubblicazionePublished - 2016

All Science Journal Classification (ASJC) codes

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