High prevalence of integron-mediated resistance in clinical isolates of Salmonella enterica

Caterina Mammina, Shohreh Farshad, Bahman Tabaraie, Parviz Owlia, Ali Naghoni, Zahra Safiri, Reza Ranjbar

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    Abstract

    Salmonella enterica has become progressively resistant to antimicrobial agents worldwide as a result of genes carried on different classes of integrons. The aim of the current study was to investigate the molecular diversity of these integrons and their association with antimicrobial resistance in clinical S. enterica isolates from Tehran, Iran. Antimicrobial susceptibility testing was performed according to the Clinical and Laboratory Standards Institute. The presence of integrons was investigated by PCR using specific primers. Integrons were detected in 65 (47.1%) strains, with classes 1 and 2 being observed in 54 (39%) and 11 (8%) strains, respectively. Integron-positive isolates belonged to seven different S. enterica serovars, and all showed a multidrug-resistant (MDR) phenotype. Our findings show that integrons are widely disseminated among S. enterica strains from Tehran. Furthermore, the results that class 1 integrons were more prevalent than class 2 in Salmonella isolates, and that a statistical association with MDR patterns was observed, suggest that they are more likely to be important in conferring a resistant phenotype to Salmonella strains.
    Lingua originaleEnglish
    pagine (da-a)417-421
    Numero di pagine5
    RivistaJapanese Journal of Infectious Diseases
    Volume63
    Stato di pubblicazionePublished - 2010

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    All Science Journal Classification (ASJC) codes

    • Microbiology (medical)
    • Infectious Diseases

    Cita questo

    Mammina, C., Farshad, S., Tabaraie, B., Owlia, P., Naghoni, A., Safiri, Z., & Ranjbar, R. (2010). High prevalence of integron-mediated resistance in clinical isolates of Salmonella enterica. Japanese Journal of Infectious Diseases, 63, 417-421.