High-Intensity Focused Ultrasound- and Radiation Therapy-Induced Immuno-modulation: Comparison and Potential Opportunities

Domenico Lio, Vincenzo Cavalieri, Luigi Minafra, Laura Castiglia, Maria Carla Gilardi, Giorgio Russo, Valentina Bravatà, Francesco Paolo Cammarata, Federica Maria Di Maggio, Roberta Cirincione, Laura Castiglia, Giovanni Borasi, Giusi Irma Forte, Cristina Messa

Risultato della ricerca: Article

11 Citazioni (Scopus)

Abstract

In recent years, high-intensity focused ultrasound (HIFU) has emerged as a new and promising non-invasive and non-ionizing ablative technique for the treatment of localized solid tumors. Extensive pre-clinical and clinical studies have evidenced that, in addition to direct destruction of the primary tumor, HIFU-thermoablation may elicit long-term systemic host anti-tumor immunity. In particular, an important consequence of HIFU treatment includes the release of tumor-associated antigens (TAAs), the secretion of immuno-suppressing factors by cancer cells and the induction of cytotoxic T lymphocyte (CTL) activity. Radiation therapy (RT) is the main treatment modality used for many types of tumors and about 50% of all cancer patients receive RT, often used in combination with surgery and chemotherapy. It is well known that RT can modulate anti-tumor immune responses, modifying micro-environment and stimulating inflammatory factors that can greatly affect cell invasion, bystander effects, radiation tissue complications (such as fibrosis), genomic instability and thus, intrinsic cellular radio-sensitivity. To date, various combined therapeutic strategies (such as immuno-therapy) have been performed in order to enhance RT success in treating locally advanced and recurrent tumors. Recent works suggested the combined use of HIFU and RT treatments to increase the tumor cell radio-sensitivity, in order to synergize the effects reaching the maximum results with minimal doses of ionizing radiation (IR). Here, we highlight the opposite immuno-modulation roles of RT and HIFU, providing scientific reasons to test, by experimental approaches, the use of HIFU immune-stimulatory capacity to improve tumor radio-sensitivity, to reduce the RT induced inflammatory response and to decrease the dose-correlated side effects in normal tissues.
Lingua originaleEnglish
pagine (da-a)398-411
Numero di pagine14
RivistaUltrasound in Medicine and Biology
Volume43
Stato di pubblicazionePublished - 2017

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radiation therapy
Radiotherapy
tumors
modulation
Neoplasms
radiation tolerance
Radio
cancer
Therapeutics
Ultrasonic Waves
fibrosis
dosage
Bystander Effect
secretions
lymphocytes
immunity
antigens
radiation effects
chemotherapy
Genomic Instability

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics

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High-Intensity Focused Ultrasound- and Radiation Therapy-Induced Immuno-modulation: Comparison and Potential Opportunities. / Lio, Domenico; Cavalieri, Vincenzo; Minafra, Luigi; Castiglia, Laura; Gilardi, Maria Carla; Russo, Giorgio; Bravatà, Valentina; Cammarata, Francesco Paolo; Di Maggio, Federica Maria; Cirincione, Roberta; Castiglia, Laura; Borasi, Giovanni; Forte, Giusi Irma; Messa, Cristina.

In: Ultrasound in Medicine and Biology, Vol. 43, 2017, pag. 398-411.

Risultato della ricerca: Article

Lio, D, Cavalieri, V, Minafra, L, Castiglia, L, Gilardi, MC, Russo, G, Bravatà, V, Cammarata, FP, Di Maggio, FM, Cirincione, R, Castiglia, L, Borasi, G, Forte, GI & Messa, C 2017, 'High-Intensity Focused Ultrasound- and Radiation Therapy-Induced Immuno-modulation: Comparison and Potential Opportunities', Ultrasound in Medicine and Biology, vol. 43, pagg. 398-411.
Lio, Domenico ; Cavalieri, Vincenzo ; Minafra, Luigi ; Castiglia, Laura ; Gilardi, Maria Carla ; Russo, Giorgio ; Bravatà, Valentina ; Cammarata, Francesco Paolo ; Di Maggio, Federica Maria ; Cirincione, Roberta ; Castiglia, Laura ; Borasi, Giovanni ; Forte, Giusi Irma ; Messa, Cristina. / High-Intensity Focused Ultrasound- and Radiation Therapy-Induced Immuno-modulation: Comparison and Potential Opportunities. In: Ultrasound in Medicine and Biology. 2017 ; Vol. 43. pagg. 398-411.
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abstract = "In recent years, high-intensity focused ultrasound (HIFU) has emerged as a new and promising non-invasive and non-ionizing ablative technique for the treatment of localized solid tumors. Extensive pre-clinical and clinical studies have evidenced that, in addition to direct destruction of the primary tumor, HIFU-thermoablation may elicit long-term systemic host anti-tumor immunity. In particular, an important consequence of HIFU treatment includes the release of tumor-associated antigens (TAAs), the secretion of immuno-suppressing factors by cancer cells and the induction of cytotoxic T lymphocyte (CTL) activity. Radiation therapy (RT) is the main treatment modality used for many types of tumors and about 50{\%} of all cancer patients receive RT, often used in combination with surgery and chemotherapy. It is well known that RT can modulate anti-tumor immune responses, modifying micro-environment and stimulating inflammatory factors that can greatly affect cell invasion, bystander effects, radiation tissue complications (such as fibrosis), genomic instability and thus, intrinsic cellular radio-sensitivity. To date, various combined therapeutic strategies (such as immuno-therapy) have been performed in order to enhance RT success in treating locally advanced and recurrent tumors. Recent works suggested the combined use of HIFU and RT treatments to increase the tumor cell radio-sensitivity, in order to synergize the effects reaching the maximum results with minimal doses of ionizing radiation (IR). Here, we highlight the opposite immuno-modulation roles of RT and HIFU, providing scientific reasons to test, by experimental approaches, the use of HIFU immune-stimulatory capacity to improve tumor radio-sensitivity, to reduce the RT induced inflammatory response and to decrease the dose-correlated side effects in normal tissues.",
author = "Domenico Lio and Vincenzo Cavalieri and Luigi Minafra and Laura Castiglia and Gilardi, {Maria Carla} and Giorgio Russo and Valentina Bravat{\`a} and Cammarata, {Francesco Paolo} and {Di Maggio}, {Federica Maria} and Roberta Cirincione and Laura Castiglia and Giovanni Borasi and Forte, {Giusi Irma} and Cristina Messa",
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T1 - High-Intensity Focused Ultrasound- and Radiation Therapy-Induced Immuno-modulation: Comparison and Potential Opportunities

AU - Lio, Domenico

AU - Cavalieri, Vincenzo

AU - Minafra, Luigi

AU - Castiglia, Laura

AU - Gilardi, Maria Carla

AU - Russo, Giorgio

AU - Bravatà, Valentina

AU - Cammarata, Francesco Paolo

AU - Di Maggio, Federica Maria

AU - Cirincione, Roberta

AU - Castiglia, Laura

AU - Borasi, Giovanni

AU - Forte, Giusi Irma

AU - Messa, Cristina

PY - 2017

Y1 - 2017

N2 - In recent years, high-intensity focused ultrasound (HIFU) has emerged as a new and promising non-invasive and non-ionizing ablative technique for the treatment of localized solid tumors. Extensive pre-clinical and clinical studies have evidenced that, in addition to direct destruction of the primary tumor, HIFU-thermoablation may elicit long-term systemic host anti-tumor immunity. In particular, an important consequence of HIFU treatment includes the release of tumor-associated antigens (TAAs), the secretion of immuno-suppressing factors by cancer cells and the induction of cytotoxic T lymphocyte (CTL) activity. Radiation therapy (RT) is the main treatment modality used for many types of tumors and about 50% of all cancer patients receive RT, often used in combination with surgery and chemotherapy. It is well known that RT can modulate anti-tumor immune responses, modifying micro-environment and stimulating inflammatory factors that can greatly affect cell invasion, bystander effects, radiation tissue complications (such as fibrosis), genomic instability and thus, intrinsic cellular radio-sensitivity. To date, various combined therapeutic strategies (such as immuno-therapy) have been performed in order to enhance RT success in treating locally advanced and recurrent tumors. Recent works suggested the combined use of HIFU and RT treatments to increase the tumor cell radio-sensitivity, in order to synergize the effects reaching the maximum results with minimal doses of ionizing radiation (IR). Here, we highlight the opposite immuno-modulation roles of RT and HIFU, providing scientific reasons to test, by experimental approaches, the use of HIFU immune-stimulatory capacity to improve tumor radio-sensitivity, to reduce the RT induced inflammatory response and to decrease the dose-correlated side effects in normal tissues.

AB - In recent years, high-intensity focused ultrasound (HIFU) has emerged as a new and promising non-invasive and non-ionizing ablative technique for the treatment of localized solid tumors. Extensive pre-clinical and clinical studies have evidenced that, in addition to direct destruction of the primary tumor, HIFU-thermoablation may elicit long-term systemic host anti-tumor immunity. In particular, an important consequence of HIFU treatment includes the release of tumor-associated antigens (TAAs), the secretion of immuno-suppressing factors by cancer cells and the induction of cytotoxic T lymphocyte (CTL) activity. Radiation therapy (RT) is the main treatment modality used for many types of tumors and about 50% of all cancer patients receive RT, often used in combination with surgery and chemotherapy. It is well known that RT can modulate anti-tumor immune responses, modifying micro-environment and stimulating inflammatory factors that can greatly affect cell invasion, bystander effects, radiation tissue complications (such as fibrosis), genomic instability and thus, intrinsic cellular radio-sensitivity. To date, various combined therapeutic strategies (such as immuno-therapy) have been performed in order to enhance RT success in treating locally advanced and recurrent tumors. Recent works suggested the combined use of HIFU and RT treatments to increase the tumor cell radio-sensitivity, in order to synergize the effects reaching the maximum results with minimal doses of ionizing radiation (IR). Here, we highlight the opposite immuno-modulation roles of RT and HIFU, providing scientific reasons to test, by experimental approaches, the use of HIFU immune-stimulatory capacity to improve tumor radio-sensitivity, to reduce the RT induced inflammatory response and to decrease the dose-correlated side effects in normal tissues.

UR - http://hdl.handle.net/10447/206219

M3 - Article

VL - 43

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EP - 411

JO - Ultrasound in Medicine and Biology

JF - Ultrasound in Medicine and Biology

SN - 0301-5629

ER -