High dose of 8-OH-DPAT decreases maximal dentate gyrus activation and facilitates granular cell plasticity in vivo.

Arcangelo Benigno, Gergely Orban, Salvatore Galati, Mario Valentino, Gergely Orban, Massimo Pierucci, Mauro Pessia, Richard Muscat, Giuseppe Di Giovanni

    Risultato della ricerca: Articlepeer review

    17 Citazioni (Scopus)

    Abstract

    Although several studies have emphasized a crucial role for the serotonergic system in the control of hippocampal excitability, the role of serotonin (5-HT) and its receptors in normal and pathologic conditions, such as temporal lobe epilepsy (TLE), is still unclear. The present study was therefore designed firstly to investigate the acute effect of 8-OH-DPAT, a mixed 5-HT1A/7 receptor agonist, at a high dose (1 mg/kg, i.p.) known to have antiepileptic properties, in a model of acute partial epilepsy in rats. For this purpose, a maximal dentate activation (MDA) protocol was used to measure electrographic seizure onset and duration. In addition, the effect of 8-OH-DPAT on in vivo dentate gyrus cell reactivity and short- and long-term plasticity was studied. Rats injected with 8-OH-DPAT exhibited a significant reduction in MDA and epileptic discharges, a decrease in paired-pulse facilitation and an increase in long-term potentiation. This study suggests that 8-OH-DPAT or in general 5-HT1A/7 agonists might be useful for the treatment of TLE and also have some beneficial effects on the comorbid cognitive disorders seen in epileptic patients.
    Lingua originaleEnglish
    pagine (da-a)441-451
    Numero di pagine11
    RivistaExperimental Brain Research
    Volume230
    Stato di pubblicazionePublished - 2013

    All Science Journal Classification (ASJC) codes

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