Heterogeneity within and between primary colorectal carcinomas and matched metastases as revealed by analysis of Ki-ras and p53 mutations

Ida Albanese, Rosa Maria Tomasino, Mario La Farina, Marcello Tagliavia, Antonio Russo, Viviana Bazan, Antonio Russo, Angelo Giuseppe Scibetta, Manuela Migliavacca, Viviana Bazan, Paolo Colomba

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81 Citazioni (Scopus)

Abstract

Analysis of the genetic status of Ki-ras and p53 in primary colorectal carcinomas and matched colorectal liver metastasis from 30 patients reveals an overall heterogeneity both within and between the two tumoral tissues. Both genes were found mutated with a similar frequency in both tissues; however, identical mutations in primary tumor and matched metastasis were found less frequently in the case of the Ki-ras than the p53 gene. Only in three cases the same p53 and Ki-ras mutations found in the primary tumor were found also in the metastasis. In several metastatic specimens the DNA bearing a mutation detected also in the primary tumor appears significantly less abundant than the wild-type DNA. These data are discussed in the light of current models of primary tumor/metastasis relationships.
Lingua originaleEnglish
pagine (da-a)784-791
Numero di pagine8
RivistaBiochemical and Biophysical Research Communications
Volume325
Stato di pubblicazionePublished - 2004

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All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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