81 Citazioni (Scopus)

Abstract

Apoptosis is a form of cell death that permits the removal of damaged, senescent or unwanted cells inmulticellular organisms, without damage to the cellular microenvironment. Defective apoptosis representsa major causative factor in the development and progression of cancer. The majority of chemotherapeuticagents, as well as radiation, utilize the apoptotic pathway to induce cancer cell death. Resistance to standardchemotherapeutic strategies also seems to be due to alterations in the apoptotic pathway of cancer cells.Recent knowledge on apoptosis has provided the basis for novel targeted therapies that exploit apoptosis totreat cancer. These new target include those acting in the extrinsic/intrinsic pathway, proteins that control theapoptosis machinery such as the p53 and proteosome pathway. Most of these forms of therapy are still inpreclinical development because of their low specifity and susceptibility to drug resistance, but several of themhave shown promising results. In particular, this review specifically aims at providing an update of certainmolecular players that are already in use in order to target apoptosis (such as bortezomib) or which are still beingclinically evaluated (such ONYX-015, survivin and exisulind/aptosyn) or which, following preclinical studies,might have the necessary requirements for becoming part of the anticancer drug programs (such as TRAIL/Apo2L, apoptin/VP3).Key words: apoptosis, TRAIL/Apo2L, apoptin/VP3, ONYX015, Bortezomib, exisulind, survivin
Lingua originaleEnglish
pagine (da-a)28-44
Numero di pagine17
RivistaCRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume69
Stato di pubblicazionePublished - 2009

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2700.2730???

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