Hepatocellular carcinoma in cirrhotic patients at MDCT: hepatic venous phase versus delayed phase for the detection of tumour washout

Giuseppe Brancatelli, Massimo Midiri, Roberto Lagalla, Vanzulli, Ronzoni, Alessandro Furlan, Giuseppe Brancatelli, Bazzocchi, Daniele Marin

Risultato della ricerca: Article

33 Citazioni (Scopus)

Abstract

OBJECTIVES:Our aim was to compare retrospectively hepatic venous and delayed phase images for the detection of tumour washout during multiphasic multidetector row CT (MDCT) of the liver in patients with hepatocellular carcinoma (HCC).METHODS:30 cirrhotic patients underwent multiphasic MDCT in the 90 days before liver transplantation. MDCT was performed before contrast medium administration and during hepatic arterial hepatic venous and delayed phases, images were obtained at 12, 55 and 120 s after trigger threshold. Two radiologists qualitatively evaluated images for lesion attenuation. Tumour washout was evaluated subjectively and objectively. Tumour-to-liver contrast (TLC) was measured for all pathologically proven HCCs.RESULTS:48 HCCs were detected at MDCT. 46 of the 48 tumours (96%) appeared as either hyper- or isoattenuating during the hepatic arterial phase subjective washout was present in 15 HCCs (33%) during the hepatic venous phase and in 35 (76%) during the delayed phase (p<0.001, McNemar's test). Objective washout was present in 30 of the 46 HCCs (65%) during the hepatic venous phase and in 42 of the HCCs (91%) during the delayed phase (p=0.001). The delayed phase yielded significantly higher mean TLC absolute values compared with the hepatic venous phase (-16.1±10.8 HU vs -10.5±10.2 HU; p<0.001).CONCLUSIONS:The delayed phase is superior to the hepatic venous phase for detection of tumour washout of pathologically proven HCC in cirrhotic patients.
Lingua originaleEnglish
Numero di pagine10
RivistaBritish Journal of Radiology
Volume84
Stato di pubblicazionePublished - 2011

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Hepatocellular Carcinoma
Liver
Neoplasms
Liver Transplantation
Contrast Media

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cita questo

Hepatocellular carcinoma in cirrhotic patients at MDCT: hepatic venous phase versus delayed phase for the detection of tumour washout. / Brancatelli, Giuseppe; Midiri, Massimo; Lagalla, Roberto; Vanzulli; Ronzoni; Furlan, Alessandro; Brancatelli, Giuseppe; Bazzocchi; Marin, Daniele.

In: British Journal of Radiology, Vol. 84, 2011.

Risultato della ricerca: Article

@article{73e81bf57acf4b69b9c0d11147f9874a,
title = "Hepatocellular carcinoma in cirrhotic patients at MDCT: hepatic venous phase versus delayed phase for the detection of tumour washout",
abstract = "OBJECTIVES:Our aim was to compare retrospectively hepatic venous and delayed phase images for the detection of tumour washout during multiphasic multidetector row CT (MDCT) of the liver in patients with hepatocellular carcinoma (HCC).METHODS:30 cirrhotic patients underwent multiphasic MDCT in the 90 days before liver transplantation. MDCT was performed before contrast medium administration and during hepatic arterial hepatic venous and delayed phases, images were obtained at 12, 55 and 120 s after trigger threshold. Two radiologists qualitatively evaluated images for lesion attenuation. Tumour washout was evaluated subjectively and objectively. Tumour-to-liver contrast (TLC) was measured for all pathologically proven HCCs.RESULTS:48 HCCs were detected at MDCT. 46 of the 48 tumours (96{\%}) appeared as either hyper- or isoattenuating during the hepatic arterial phase subjective washout was present in 15 HCCs (33{\%}) during the hepatic venous phase and in 35 (76{\%}) during the delayed phase (p<0.001, McNemar's test). Objective washout was present in 30 of the 46 HCCs (65{\%}) during the hepatic venous phase and in 42 of the HCCs (91{\%}) during the delayed phase (p=0.001). The delayed phase yielded significantly higher mean TLC absolute values compared with the hepatic venous phase (-16.1±10.8 HU vs -10.5±10.2 HU; p<0.001).CONCLUSIONS:The delayed phase is superior to the hepatic venous phase for detection of tumour washout of pathologically proven HCC in cirrhotic patients.",
keywords = "CT, HCC, Liver",
author = "Giuseppe Brancatelli and Massimo Midiri and Roberto Lagalla and Vanzulli and Ronzoni and Alessandro Furlan and Giuseppe Brancatelli and Bazzocchi and Daniele Marin",
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TY - JOUR

T1 - Hepatocellular carcinoma in cirrhotic patients at MDCT: hepatic venous phase versus delayed phase for the detection of tumour washout

AU - Brancatelli, Giuseppe

AU - Midiri, Massimo

AU - Lagalla, Roberto

AU - Vanzulli, null

AU - Ronzoni, null

AU - Furlan, Alessandro

AU - Brancatelli, Giuseppe

AU - Bazzocchi, null

AU - Marin, Daniele

PY - 2011

Y1 - 2011

N2 - OBJECTIVES:Our aim was to compare retrospectively hepatic venous and delayed phase images for the detection of tumour washout during multiphasic multidetector row CT (MDCT) of the liver in patients with hepatocellular carcinoma (HCC).METHODS:30 cirrhotic patients underwent multiphasic MDCT in the 90 days before liver transplantation. MDCT was performed before contrast medium administration and during hepatic arterial hepatic venous and delayed phases, images were obtained at 12, 55 and 120 s after trigger threshold. Two radiologists qualitatively evaluated images for lesion attenuation. Tumour washout was evaluated subjectively and objectively. Tumour-to-liver contrast (TLC) was measured for all pathologically proven HCCs.RESULTS:48 HCCs were detected at MDCT. 46 of the 48 tumours (96%) appeared as either hyper- or isoattenuating during the hepatic arterial phase subjective washout was present in 15 HCCs (33%) during the hepatic venous phase and in 35 (76%) during the delayed phase (p<0.001, McNemar's test). Objective washout was present in 30 of the 46 HCCs (65%) during the hepatic venous phase and in 42 of the HCCs (91%) during the delayed phase (p=0.001). The delayed phase yielded significantly higher mean TLC absolute values compared with the hepatic venous phase (-16.1±10.8 HU vs -10.5±10.2 HU; p<0.001).CONCLUSIONS:The delayed phase is superior to the hepatic venous phase for detection of tumour washout of pathologically proven HCC in cirrhotic patients.

AB - OBJECTIVES:Our aim was to compare retrospectively hepatic venous and delayed phase images for the detection of tumour washout during multiphasic multidetector row CT (MDCT) of the liver in patients with hepatocellular carcinoma (HCC).METHODS:30 cirrhotic patients underwent multiphasic MDCT in the 90 days before liver transplantation. MDCT was performed before contrast medium administration and during hepatic arterial hepatic venous and delayed phases, images were obtained at 12, 55 and 120 s after trigger threshold. Two radiologists qualitatively evaluated images for lesion attenuation. Tumour washout was evaluated subjectively and objectively. Tumour-to-liver contrast (TLC) was measured for all pathologically proven HCCs.RESULTS:48 HCCs were detected at MDCT. 46 of the 48 tumours (96%) appeared as either hyper- or isoattenuating during the hepatic arterial phase subjective washout was present in 15 HCCs (33%) during the hepatic venous phase and in 35 (76%) during the delayed phase (p<0.001, McNemar's test). Objective washout was present in 30 of the 46 HCCs (65%) during the hepatic venous phase and in 42 of the HCCs (91%) during the delayed phase (p=0.001). The delayed phase yielded significantly higher mean TLC absolute values compared with the hepatic venous phase (-16.1±10.8 HU vs -10.5±10.2 HU; p<0.001).CONCLUSIONS:The delayed phase is superior to the hepatic venous phase for detection of tumour washout of pathologically proven HCC in cirrhotic patients.

KW - CT

KW - HCC

KW - Liver

UR - http://hdl.handle.net/10447/59377

M3 - Article

VL - 84

JO - British Journal of Radiology

JF - British Journal of Radiology

SN - 0007-1285

ER -