10 Citazioni (Scopus)


Aims: To analyze the main etiological factors and some clinical characteristics of patients with HCC atdiagnosis and to compare them with those we described ten years ago.Methods: 179 patients were included in Group 1, while 132 patients were included in Group 2. For allpatients age, sex, serum markers of hepatitis B and C viruses, alcohol consumption, serum alpha feto-protein(AFP) levels and the main liver function parameters at HCC diagnosis were recorded.Results: Mean age was 66.0 years for Group 1 and 69.0 for Group 2 (P=0.005). HCV was responsible for80.3% of HCC cases in Group 2 versus 72% in Group 1 (P=0.005). HBV alone and co-infection of HCV+HBVdecreased, but not significantly. In Group 1 only four patients had an underlying normal liver, while in Group2 no patients showed an underlying normal liver (P=ns). HCC was more frequently associated with Childclass A in Group 2 (P=0.0001), whereas in Group 1 it was more frequently associated with class C(P=0.0001). Staging of HCC correlated inversely when patients of Groups 1 and 2 were compared (Pb0.03).AFP serum levels were above normal in 72% of cases in Group 1 and in 41.5% in Group 2 (P=0.0001).Conclusion: This study shows that over the last decade a number of characteristics of patients with HCC in ourregion have changed, particularly age at onset of HCC, staging of underlying liver disease and staging of HCC.
Lingua originaleEnglish
Numero di pagine4
RivistaEuropean Journal of Internal Medicine
Stato di pubblicazionePublished - 2010

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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