TY - JOUR
T1 - Hemophagocytic syndrome in a patient with disseminated tuberculosis: A case report
AU - Soresi, Maurizio
AU - Giannitrapani, Lydia
AU - Terranova, Antonino
AU - Florena, Ada Maria
AU - Terranova, Antonino
AU - Affronti, Andrea
AU - Florena, Ada Maria
AU - Puccia, Fania
AU - Lombardo, Vania
AU - Giannitrapani, Lydia
AU - Soresi, Maurizio
AU - Affronti, Andrea
AU - Puccia, Fania
AU - Lombardo, Vania
PY - 2018
Y1 - 2018
N2 - Hemophagocytic syndrome (HS) is a rare disorder of the immune system. It is characterized by fever, lymphadenopathy, hepatosplenomegaly, cytopenia and hyperferritinemia. The cause differs in each country suggesting a specific genetic background and epidemiology of infections, and it can be associated with malignant diseases. A rare cause of HS is tuberculosis (TB), we describe a case of HS associated with disseminated Mycobacterium tuberculosis (MT) infection in a patient from Sudan. He presented diarrhea, fever, pancytopenia, thickened and dilated bowel loops and lymph nodes enlargement at ultrasound and computed tomography scan. A bone marrow biopsy performed to rule out a lymphoma revealed a HS. The bronchoalveolar lavage (BAL) culture was then positive for MT and subsequently, radiologic aspects of lung and spleen TB involvement appeared. A disseminated tuberculosis was diagnosed. Despite antituberculous therapy, the patient died as in approximately 50% of the HS associated with TB. nly
AB - Hemophagocytic syndrome (HS) is a rare disorder of the immune system. It is characterized by fever, lymphadenopathy, hepatosplenomegaly, cytopenia and hyperferritinemia. The cause differs in each country suggesting a specific genetic background and epidemiology of infections, and it can be associated with malignant diseases. A rare cause of HS is tuberculosis (TB), we describe a case of HS associated with disseminated Mycobacterium tuberculosis (MT) infection in a patient from Sudan. He presented diarrhea, fever, pancytopenia, thickened and dilated bowel loops and lymph nodes enlargement at ultrasound and computed tomography scan. A bone marrow biopsy performed to rule out a lymphoma revealed a HS. The bronchoalveolar lavage (BAL) culture was then positive for MT and subsequently, radiologic aspects of lung and spleen TB involvement appeared. A disseminated tuberculosis was diagnosed. Despite antituberculous therapy, the patient died as in approximately 50% of the HS associated with TB. nly
KW - Hemophagocytic lymphohistiocytosis disseminated tuberculosis
KW - Hemophagocytic syndrome
KW - Medicine (all)
KW - Mycobacterium tuberculosis
KW - Hemophagocytic lymphohistiocytosis disseminated tuberculosis
KW - Hemophagocytic syndrome
KW - Medicine (all)
KW - Mycobacterium tuberculosis
UR - http://hdl.handle.net/10447/288849
UR - http://italjmed.org/index.php/ijm/article/view/itjm.2018.932/1064
M3 - Article
VL - 12
SP - 61
EP - 66
JO - Italian Journal of Medicine
JF - Italian Journal of Medicine
SN - 1877-9344
ER -