Hemophagocytic syndrome in a patient with disseminated tuberculosis: A case report

Maurizio Soresi, Lydia Giannitrapani, Antonino Terranova, Ada Maria Florena, Antonino Terranova, Andrea Affronti, Ada Maria Florena, Fania Puccia, Vania Lombardo, Lydia Giannitrapani, Maurizio Soresi, Andrea Affronti, Fania Puccia, Vania Lombardo

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1 Citazioni (Scopus)


Hemophagocytic syndrome (HS) is a rare disorder of the immune system. It is characterized by fever, lymphadenopathy, hepatosplenomegaly, cytopenia and hyperferritinemia. The cause differs in each country suggesting a specific genetic background and epidemiology of infections, and it can be associated with malignant diseases. A rare cause of HS is tuberculosis (TB), we describe a case of HS associated with disseminated Mycobacterium tuberculosis (MT) infection in a patient from Sudan. He presented diarrhea, fever, pancytopenia, thickened and dilated bowel loops and lymph nodes enlargement at ultrasound and computed tomography scan. A bone marrow biopsy performed to rule out a lymphoma revealed a HS. The bronchoalveolar lavage (BAL) culture was then positive for MT and subsequently, radiologic aspects of lung and spleen TB involvement appeared. A disseminated tuberculosis was diagnosed. Despite antituberculous therapy, the patient died as in approximately 50% of the HS associated with TB. nly
Lingua originaleEnglish
pagine (da-a)61-66
Numero di pagine6
RivistaItalian Journal of Medicine
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

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