Hemodynamic changes in splanchnic circulation after orthotopic liver transplantation in patients with liver cirrhosis

Giuseppe Montalto, Maurizio Soresi, Antonio Carroccio, Carmela Magliarisi, Florinda Bascone, Pietro Campagna

Risultato della ricerca: Article

8 Citazioni (Scopus)

Abstract

Background: Liver cirrhosis increases portal vein pressure and alters the splanchnic circulation. With Doppler sonography, we investigated the hemodynamic changes in the portal vein, superior mesenteric artery, hepatic and splenic arteries and spleen size in a group of patients with end-stage liver disease before and after orthotopic liver transplantation (OLT). Methods: Ten patients (seven male, three female; mean age = 48.8 ± 7.6 years) who underwent OLT for liver cirrhosis mainly associated with hepatitis C virus infection completed the study. The control group consisted of 10 patients matched by sex and age who had no gastroenterologic or vascular diseases. All patients underwent duplex Doppler sonography (Toshiba SSA 270A with a 3.5-MHz probe) after 24 h of fasting (baseline) and then 6 and 12 months after OLT. The following parameters, expressed as the mean of three measurements, were evaluated: portal flow velocity (PFV), pulsatility index of the superior mesenteric artery (MAPI), resistance indexes of the hepatic (HARI) and splenic (SARI) arteries, and longitudinal diameter of the spleen (LDS). Results: PFV in the pre-OLT phase was significantly lower in the patients than in the controls (p < 0.0001); it progressively and significantly increased over baseline levels at 6 and 12 months (p < 0.0001), approaching control values. LDS in the pre-OLT phase was significantly higher than in controls (p < 0.0001); after OLT, it decreased significantly compared with baseline values (p < 0.005). The MAPI of patients in the pre-OLT phase was lower than that in controls (p < 0.0001); post-OLT, it progressively increased and reached values that were significantly above baseline at 12 months (p < 0.005). In the pre-OLT phase, the HARI and SARI were significantly higher than in controls (p < 0.04); 6 and 12 months after OLT, those values were significantly below baseline values (p < 0.001), and there was no significant difference from control values. Conclusion: These data show that many of the hemodynamic parameters typical of decompensated cirrhosis improve progressively within 12 months after transplantation.
Lingua originaleEnglish
pagine (da-a)541-545
Numero di pagine5
RivistaABDOMINAL IMAGING
Volume27
Stato di pubblicazionePublished - 2002

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Splanchnic Circulation
Liver Cirrhosis
Liver Transplantation
Hemodynamics
Splenic Artery
Superior Mesenteric Artery
Spleen
Portal Vein
Doppler Duplex Ultrasonography
Portal Pressure
Doppler Ultrasonography
End Stage Liver Disease
Hepatic Artery
Virus Diseases
Vascular Diseases
Hepacivirus
Fasting
Fibrosis
Transplantation

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Gastroenterology
  • Urology

Cita questo

Hemodynamic changes in splanchnic circulation after orthotopic liver transplantation in patients with liver cirrhosis. / Montalto, Giuseppe; Soresi, Maurizio; Carroccio, Antonio; Magliarisi, Carmela; Bascone, Florinda; Campagna, Pietro.

In: ABDOMINAL IMAGING, Vol. 27, 2002, pag. 541-545.

Risultato della ricerca: Article

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title = "Hemodynamic changes in splanchnic circulation after orthotopic liver transplantation in patients with liver cirrhosis",
abstract = "Background: Liver cirrhosis increases portal vein pressure and alters the splanchnic circulation. With Doppler sonography, we investigated the hemodynamic changes in the portal vein, superior mesenteric artery, hepatic and splenic arteries and spleen size in a group of patients with end-stage liver disease before and after orthotopic liver transplantation (OLT). Methods: Ten patients (seven male, three female; mean age = 48.8 ± 7.6 years) who underwent OLT for liver cirrhosis mainly associated with hepatitis C virus infection completed the study. The control group consisted of 10 patients matched by sex and age who had no gastroenterologic or vascular diseases. All patients underwent duplex Doppler sonography (Toshiba SSA 270A with a 3.5-MHz probe) after 24 h of fasting (baseline) and then 6 and 12 months after OLT. The following parameters, expressed as the mean of three measurements, were evaluated: portal flow velocity (PFV), pulsatility index of the superior mesenteric artery (MAPI), resistance indexes of the hepatic (HARI) and splenic (SARI) arteries, and longitudinal diameter of the spleen (LDS). Results: PFV in the pre-OLT phase was significantly lower in the patients than in the controls (p < 0.0001); it progressively and significantly increased over baseline levels at 6 and 12 months (p < 0.0001), approaching control values. LDS in the pre-OLT phase was significantly higher than in controls (p < 0.0001); after OLT, it decreased significantly compared with baseline values (p < 0.005). The MAPI of patients in the pre-OLT phase was lower than that in controls (p < 0.0001); post-OLT, it progressively increased and reached values that were significantly above baseline at 12 months (p < 0.005). In the pre-OLT phase, the HARI and SARI were significantly higher than in controls (p < 0.04); 6 and 12 months after OLT, those values were significantly below baseline values (p < 0.001), and there was no significant difference from control values. Conclusion: These data show that many of the hemodynamic parameters typical of decompensated cirrhosis improve progressively within 12 months after transplantation.",
author = "Giuseppe Montalto and Maurizio Soresi and Antonio Carroccio and Carmela Magliarisi and Florinda Bascone and Pietro Campagna",
year = "2002",
language = "English",
volume = "27",
pages = "541--545",
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TY - JOUR

T1 - Hemodynamic changes in splanchnic circulation after orthotopic liver transplantation in patients with liver cirrhosis

AU - Montalto, Giuseppe

AU - Soresi, Maurizio

AU - Carroccio, Antonio

AU - Magliarisi, Carmela

AU - Bascone, Florinda

AU - Campagna, Pietro

PY - 2002

Y1 - 2002

N2 - Background: Liver cirrhosis increases portal vein pressure and alters the splanchnic circulation. With Doppler sonography, we investigated the hemodynamic changes in the portal vein, superior mesenteric artery, hepatic and splenic arteries and spleen size in a group of patients with end-stage liver disease before and after orthotopic liver transplantation (OLT). Methods: Ten patients (seven male, three female; mean age = 48.8 ± 7.6 years) who underwent OLT for liver cirrhosis mainly associated with hepatitis C virus infection completed the study. The control group consisted of 10 patients matched by sex and age who had no gastroenterologic or vascular diseases. All patients underwent duplex Doppler sonography (Toshiba SSA 270A with a 3.5-MHz probe) after 24 h of fasting (baseline) and then 6 and 12 months after OLT. The following parameters, expressed as the mean of three measurements, were evaluated: portal flow velocity (PFV), pulsatility index of the superior mesenteric artery (MAPI), resistance indexes of the hepatic (HARI) and splenic (SARI) arteries, and longitudinal diameter of the spleen (LDS). Results: PFV in the pre-OLT phase was significantly lower in the patients than in the controls (p < 0.0001); it progressively and significantly increased over baseline levels at 6 and 12 months (p < 0.0001), approaching control values. LDS in the pre-OLT phase was significantly higher than in controls (p < 0.0001); after OLT, it decreased significantly compared with baseline values (p < 0.005). The MAPI of patients in the pre-OLT phase was lower than that in controls (p < 0.0001); post-OLT, it progressively increased and reached values that were significantly above baseline at 12 months (p < 0.005). In the pre-OLT phase, the HARI and SARI were significantly higher than in controls (p < 0.04); 6 and 12 months after OLT, those values were significantly below baseline values (p < 0.001), and there was no significant difference from control values. Conclusion: These data show that many of the hemodynamic parameters typical of decompensated cirrhosis improve progressively within 12 months after transplantation.

AB - Background: Liver cirrhosis increases portal vein pressure and alters the splanchnic circulation. With Doppler sonography, we investigated the hemodynamic changes in the portal vein, superior mesenteric artery, hepatic and splenic arteries and spleen size in a group of patients with end-stage liver disease before and after orthotopic liver transplantation (OLT). Methods: Ten patients (seven male, three female; mean age = 48.8 ± 7.6 years) who underwent OLT for liver cirrhosis mainly associated with hepatitis C virus infection completed the study. The control group consisted of 10 patients matched by sex and age who had no gastroenterologic or vascular diseases. All patients underwent duplex Doppler sonography (Toshiba SSA 270A with a 3.5-MHz probe) after 24 h of fasting (baseline) and then 6 and 12 months after OLT. The following parameters, expressed as the mean of three measurements, were evaluated: portal flow velocity (PFV), pulsatility index of the superior mesenteric artery (MAPI), resistance indexes of the hepatic (HARI) and splenic (SARI) arteries, and longitudinal diameter of the spleen (LDS). Results: PFV in the pre-OLT phase was significantly lower in the patients than in the controls (p < 0.0001); it progressively and significantly increased over baseline levels at 6 and 12 months (p < 0.0001), approaching control values. LDS in the pre-OLT phase was significantly higher than in controls (p < 0.0001); after OLT, it decreased significantly compared with baseline values (p < 0.005). The MAPI of patients in the pre-OLT phase was lower than that in controls (p < 0.0001); post-OLT, it progressively increased and reached values that were significantly above baseline at 12 months (p < 0.005). In the pre-OLT phase, the HARI and SARI were significantly higher than in controls (p < 0.04); 6 and 12 months after OLT, those values were significantly below baseline values (p < 0.001), and there was no significant difference from control values. Conclusion: These data show that many of the hemodynamic parameters typical of decompensated cirrhosis improve progressively within 12 months after transplantation.

UR - http://hdl.handle.net/10447/198031

M3 - Article

VL - 27

SP - 541

EP - 545

JO - ABDOMINAL IMAGING

JF - ABDOMINAL IMAGING

SN - 0942-8925

ER -