Heat Shock Proteins in Multiple Sclerosis Pathogenesis: Friend or Foe?

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Abstract

Multiple Sclerosis is a complex chronic inflammatory, neurodegenerativedisease conditioned by genetic, epigenetic and environmental factors. Mainpathological features of MS include areas of focal demyelination of white matter characterized by gliosis, neuron and oligodendrocyte loss. Neurodegenerative as well as immune-mediated processes play a role in the pathogenesis of this disease.One of these immunogenic factors could be represented by the heat shock proteins.HSP exhibit cytoprotective and cytostimulatory effects due to their molecularchaperones role, in many brain model misfolding diseases such as Alzheimer’s and Parkinson’s diseases, whereas still no unambiguous results have been reported for autoimmune disorders of the central nervous system such as Multiple Sclerosis.Actually, either positive or negative HSP role seems to depend on HSP family and on their intracellular or extracellular localization. It will be interesting to study drug treatment which overexpress or inhibit HSP production in order to gain much more information about the role of the HSP in this disease.
Lingua originaleEnglish
Titolo della pubblicazione ospiteHeat shock protein based therapies
Pagine151-173
Numero di pagine23
Stato di pubblicazionePublished - 2015

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Heat-Shock Proteins
Multiple Sclerosis
Autoimmune Diseases of the Nervous System
Gliosis
Oligodendroglia
Demyelinating Diseases
Epigenomics
Parkinson Disease
Alzheimer Disease
Neurons
Brain
Pharmaceutical Preparations
Therapeutics

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title = "Heat Shock Proteins in Multiple Sclerosis Pathogenesis: Friend or Foe?",
abstract = "Multiple Sclerosis is a complex chronic inflammatory, neurodegenerativedisease conditioned by genetic, epigenetic and environmental factors. Mainpathological features of MS include areas of focal demyelination of white matter characterized by gliosis, neuron and oligodendrocyte loss. Neurodegenerative as well as immune-mediated processes play a role in the pathogenesis of this disease.One of these immunogenic factors could be represented by the heat shock proteins.HSP exhibit cytoprotective and cytostimulatory effects due to their molecularchaperones role, in many brain model misfolding diseases such as Alzheimer’s and Parkinson’s diseases, whereas still no unambiguous results have been reported for autoimmune disorders of the central nervous system such as Multiple Sclerosis.Actually, either positive or negative HSP role seems to depend on HSP family and on their intracellular or extracellular localization. It will be interesting to study drug treatment which overexpress or inhibit HSP production in order to gain much more information about the role of the HSP in this disease.",
author = "Walter Spinello and Giuseppina Turturici and Gabriella Sconzo and Fabiana Geraci",
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AU - Spinello, Walter

AU - Turturici, Giuseppina

AU - Sconzo, Gabriella

AU - Geraci, Fabiana

PY - 2015

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N2 - Multiple Sclerosis is a complex chronic inflammatory, neurodegenerativedisease conditioned by genetic, epigenetic and environmental factors. Mainpathological features of MS include areas of focal demyelination of white matter characterized by gliosis, neuron and oligodendrocyte loss. Neurodegenerative as well as immune-mediated processes play a role in the pathogenesis of this disease.One of these immunogenic factors could be represented by the heat shock proteins.HSP exhibit cytoprotective and cytostimulatory effects due to their molecularchaperones role, in many brain model misfolding diseases such as Alzheimer’s and Parkinson’s diseases, whereas still no unambiguous results have been reported for autoimmune disorders of the central nervous system such as Multiple Sclerosis.Actually, either positive or negative HSP role seems to depend on HSP family and on their intracellular or extracellular localization. It will be interesting to study drug treatment which overexpress or inhibit HSP production in order to gain much more information about the role of the HSP in this disease.

AB - Multiple Sclerosis is a complex chronic inflammatory, neurodegenerativedisease conditioned by genetic, epigenetic and environmental factors. Mainpathological features of MS include areas of focal demyelination of white matter characterized by gliosis, neuron and oligodendrocyte loss. Neurodegenerative as well as immune-mediated processes play a role in the pathogenesis of this disease.One of these immunogenic factors could be represented by the heat shock proteins.HSP exhibit cytoprotective and cytostimulatory effects due to their molecularchaperones role, in many brain model misfolding diseases such as Alzheimer’s and Parkinson’s diseases, whereas still no unambiguous results have been reported for autoimmune disorders of the central nervous system such as Multiple Sclerosis.Actually, either positive or negative HSP role seems to depend on HSP family and on their intracellular or extracellular localization. It will be interesting to study drug treatment which overexpress or inhibit HSP production in order to gain much more information about the role of the HSP in this disease.

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BT - Heat shock protein based therapies

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