Heat Shock Protein-60 and Risk for Cardiovascular Disease.

Francesco Cappello, Manfredi Rizzo, Giovam Battista Rini, Giovanni Zummo, Ioanna Gouni-Berthold, Everly Conway De Macario, Francesco Cappello, Alberto J.L. Macario, Manfredi Rizzo, Heiner K. Berthold

Risultato della ricerca: Articlepeer review

30 Citazioni (Scopus)

Abstract

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. There is growing evidence that molecularchaperones, many of which are heat shock proteins HSPs, are involved in CVD pathogenesis. In this review we focus on HSP60,the human mitochondrial chaperone that also displays extramitochondrial and extracellular functions. HSP60 is typically cytoprotectivebut a number of stress conditions determine its conversion to a potentially toxic molecule for cells and tissues. We present illustrative examplesof specific subtypes of CVD where HSP60 is implicated in the initiation and/or progression of disease. The data not only indicatea pathogenic role for HSP60 but also its potential as a biomarker with applications for diagnosis, assessing prognosis and response totreatment, as well as for preventing and treating CVD. © 2011 Bentham Science Publishers.
Lingua originaleEnglish
pagine (da-a)3662-3668
Numero di pagine7
RivistaCURRENT PHARMACEUTICAL DESIGN
Volume17
Stato di pubblicazionePublished - 2011

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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