Has VZV epidemiology changed in Italy? Results of a seroprevalence study

Emanuele Amodio, Francesco Vitale, Tatjana Baldovin, Savina Ditommaso, Gabriella Di Giuseppe, Paolo Bonanni, Elena Cacello, Antonella Zizza, Emanuele Amodio, Roberto Bandettini, Tolinda Gallo, Patrizia Caligiuri, Paolo Vargiu, Marta Peruzzi, Elisabetta Pagani, Parvanè Kuhdari, Cecilia Trucchi, Paolo Casalino, Laura Pellegrinelli, Martina Del MansoDanila Bassetti, Maria Rosaria Tumolo, Valentina Sciuto, Manuela Cracchiolo, Giordana Brignole, Marcella Megha, Patrizia Rossi, Paolo Romano, Anna Gamper, Sergio Bernardini, Caterina Renzoni, Anna Rita Pelliccioni, Manuela Cia, Pierlanfranco D’Agaro, Chiara Bassi, Stefania Schippa, Clelia Resciniti, Anna Maria Giandomenico, Elvira Cicerchia, Giovanni Guerra, Marco Perrone, Monica Vallerini, Francesco Maglione, Adele Idolo, Silvana Schettini, Basilio Passamonti, Guido Grasso, Savina Ditommaso, Andrea Piana, Patrizia Rossi, Emanuele Amodio, Antonella Zizza, Elisabetta Pagani, Basilio Passamonti, Patrizia Bordonaro, Laura Sticchi, Pierangela Manchia, Armando Stefanati, Patrizia Bordonaro, Francesco Bagordo, Basilio Passamonti, Paolo Fazii, Luigi Clerico, Gabriele Devoti, Valeria Primache, Antonella De Donno, Emilia Tiscione, Sandro Binda, Michela Lucia Sammarco, Marta Peruzzi, Vincenzo Baldo, Maria Cristina Rota, Francesco Vitale, Cristina Giraldi, Giovanni Gabutti, Paolo Castiglia, Antonino Bella, Marcello Guido, Silvia Lupi, Italo Angelillo, Carla Zotti, Guido Grasso, Francesca Greco, Ludovica Segat, Laura Sticchi

Risultato della ricerca: Articlepeer review

7 Citazioni (Scopus)

Abstract

The aim of the study was to evaluate if and how varicella prevalence has changed in Italy. In particular a seroprevalence study was performed, comparing it to similar surveys conducted in pre-immunization era. During 2013–2014, sera obtained from blood samples taken for diagnostic purposes or routine investigations were collected in collaboration with at least one laboratory/center for each region, following the approval of the Ethics Committee. Data were stratified by sex and age. All samples were processed in a national reference laboratory by an immunoassay with high sensitivity and specificity. Statutory notifications, national hospital discharge database and mortality data related to VZV infection were analyzed as well. A total of 3707 sera were collected and tested. In the studied period both incidence and hospitalization rates decreased and about 5 deaths per year have been registered. The seroprevalence decreased in the first year of life in subjects passively protected by their mother, followed by an increase in the following age classes. The overall antibody prevalence was 84%. The comparison with surveys conducted with the same methodology in 1996–1997 and 2003–2004 showed significant differences in age groups 1–19 y. The study confirms that in Italy VZV infection typically occurs in children. The impact of varicella on Italian population is changing. The comparison between studies performed in different periods shows a significant increase of seropositivity in age class 1–4 years, expression of vaccine interventions already adopted in some regions.
Lingua originaleEnglish
pagine (da-a)385-390
Numero di pagine6
RivistaHUMAN VACCINES & IMMUNOTHERAPEUTICS
Volume13
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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