Gut microbiota and cancer: How gut microbiota modulates activity, efficacy and toxicity of antitumoral therapy

Antonio Russo, Antonio Russo, Alessandro Inno, Antonio Russo, Stefania Gori, Guido Arcaro, Lorenzo Belluomini, Paolo Bocus, Zeno Bisoffi

Risultato della ricerca: Articlepeer review

30 Citazioni (Scopus)

Abstract

Gut microbiota is involved in gastrointestinal carcinogenesis. Also, it modulates the activity, efficacy and toxicity of several chemotherapy agents, such as gemcitabine, cyclophosphamide, irinotecan, cisplatin and 5-Fluorouracil, and target therapy, such as tyrosine kinase inhibitors. More recently, accumulating data suggest that the composition of gut microbiota may also affect efficacy and toxicity of cancer immunotherapy. Therefore, the manipulation of gut microbiota through antibiotics, probiotics, prebiotics or fecal transplantation has been investigating with the aim to improve efficacy and mitigate toxicity of anticancer drugs.
Lingua originaleEnglish
pagine (da-a)139-147
Numero di pagine9
RivistaCRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume143
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2700.2730???

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