Guillain-Barré syndrome after orthotopic liver transplantation: A clinical manifestation of immune reconstitution inflammatory syndrome?

Gianvincenzo Sparacia, Vincenzina Lo Re, Gaetano Burgio, Riccardo Volpes, Alessandra Mularoni, Ioannis Petridis, Vincenzina Lo Re, Ioannis Petridis, Gianvincenzo Sparacia, Salvatore Gruttadauria, Angelo Luca, Saša Živković, Mariapina Milazzo, Ioannis Petridis, Mariapina Milazzo

Risultato della ricerca: Articlepeer review

Abstract

Guillain-Barrè Syndrome, as part of the spectrum of dysimmune neuropathies, is unexpected to occur in immunocompromised hosts. We describe a clinical case of Guillain-Barrè syndrome, occurred a few weeks after a liver transplant, and we postulate that our case would satisfy all requirements to explain this peripheral nervous system complication as a clinical manifestation of an Immune reconstitution inflammatory syndrome. In this setting of liver transplantation, complicated by potentially multiple infective triggers, reduction of immunosuppression and reversal of pathogen-induced immunosuppression, through antimicrobial therapy, may have led to pro-inflammatory response. The pro-inflammatory pattern would have sustained the pathophysiologic mechanism of this immune neuropathy.
Lingua originaleEnglish
pagine (da-a)140-143
Numero di pagine4
RivistaClinical Neurology and Neurosurgery
Volume173
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

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