Growth hormone and hematopoiesis: A retrospective analysis on a large cohort of children with growth hormone deficiency

Piazza, G.; Radellini, S.; Mineo, M.

Risultato della ricerca: Article

Abstract

Objective: Few large-scale studies regarding the impact of GH deficiency (GHD) on hematopoiesis in children have been reported. Our aim was to investigate hematopoiesis indices in a large cohort of GHD children at diagnosis and during GH treatment (GHT) and any correlation with hormonal parameters. Design: Clinical and biochemical data of children with idiopathic GHD at diagnosis and annually up to 36 months of GHT were retrospectively evaluated. Overall, 255 children reached 12 months, 140 children 24 months and 86 children 36 months of follow-up during GHT. Results: At baseline, 18.4% of GHD children and 10.1% of controls showed normocytic anemia. GHD children showed lower hemoglobin (Hb) (p = 0.007), red blood cells (RBC) (p < 0.001) and hematocrit (Ht) (p = 0.001) than controls. During GHT, the percentage of anemic patients decreased from 18.4 to 5.4–3.5 and 4.6% after 12 (p = 0.001), 24 (p < 0.001) and 36 months (p < 0.001) of GHT, respectively. In both anemic and non-anemic patients, a significant increase in Hb (p < 0.001, <0.001 and 0.002), RBC (all p < 0.001) and Ht (all p < 0.001) was found after 12, 24 and 36 months of GHT. The Hb levels were significantly correlated with the GH peak after stimulation test (p < 0.001) at baseline and with IGF-I levels at 36 months of GHT (p = 0.002). Conclusions: A significant improvement in erythropoiesis indices occurs during GHT, regardless of any previous presence of anemia.
Lingua originaleEnglish
pagine (da-a)8-13
Numero di pagine6
RivistaGROWTH HORMONE & IGF RESEARCH
Volume42-43
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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Growth hormone and hematopoiesis: A retrospective analysis on a large cohort of children with growth hormone deficiency. / Piazza, G.; Radellini, S.; Mineo, M.

In: GROWTH HORMONE & IGF RESEARCH, Vol. 42-43, 2018, pag. 8-13.

Risultato della ricerca: Article

@article{28f044a49c6949e89b8235189a711927,
title = "Growth hormone and hematopoiesis: A retrospective analysis on a large cohort of children with growth hormone deficiency",
abstract = "Objective: Few large-scale studies regarding the impact of GH deficiency (GHD) on hematopoiesis in children have been reported. Our aim was to investigate hematopoiesis indices in a large cohort of GHD children at diagnosis and during GH treatment (GHT) and any correlation with hormonal parameters. Design: Clinical and biochemical data of children with idiopathic GHD at diagnosis and annually up to 36 months of GHT were retrospectively evaluated. Overall, 255 children reached 12 months, 140 children 24 months and 86 children 36 months of follow-up during GHT. Results: At baseline, 18.4{\%} of GHD children and 10.1{\%} of controls showed normocytic anemia. GHD children showed lower hemoglobin (Hb) (p = 0.007), red blood cells (RBC) (p < 0.001) and hematocrit (Ht) (p = 0.001) than controls. During GHT, the percentage of anemic patients decreased from 18.4 to 5.4–3.5 and 4.6{\%} after 12 (p = 0.001), 24 (p < 0.001) and 36 months (p < 0.001) of GHT, respectively. In both anemic and non-anemic patients, a significant increase in Hb (p < 0.001, <0.001 and 0.002), RBC (all p < 0.001) and Ht (all p < 0.001) was found after 12, 24 and 36 months of GHT. The Hb levels were significantly correlated with the GH peak after stimulation test (p < 0.001) at baseline and with IGF-I levels at 36 months of GHT (p = 0.002). Conclusions: A significant improvement in erythropoiesis indices occurs during GHT, regardless of any previous presence of anemia.",
keywords = "Anemia; Children; Growth hormone; Growth hormone deficiency; Growth hormone treatment; Hematopoiesis; Endocrinology, Diabetes and Metabolism; Endocrinology",
author = "{Piazza, G.; Radellini, S.; Mineo, M.} and Carla Giordano and Alessandro Ciresi and Valentina Guarnotta",
year = "2018",
language = "English",
volume = "42-43",
pages = "8--13",
journal = "Growth Hormone and IGF Research",
issn = "1096-6374",
publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Growth hormone and hematopoiesis: A retrospective analysis on a large cohort of children with growth hormone deficiency

AU - Piazza, G.; Radellini, S.; Mineo, M.

AU - Giordano, Carla

AU - Ciresi, Alessandro

AU - Guarnotta, Valentina

PY - 2018

Y1 - 2018

N2 - Objective: Few large-scale studies regarding the impact of GH deficiency (GHD) on hematopoiesis in children have been reported. Our aim was to investigate hematopoiesis indices in a large cohort of GHD children at diagnosis and during GH treatment (GHT) and any correlation with hormonal parameters. Design: Clinical and biochemical data of children with idiopathic GHD at diagnosis and annually up to 36 months of GHT were retrospectively evaluated. Overall, 255 children reached 12 months, 140 children 24 months and 86 children 36 months of follow-up during GHT. Results: At baseline, 18.4% of GHD children and 10.1% of controls showed normocytic anemia. GHD children showed lower hemoglobin (Hb) (p = 0.007), red blood cells (RBC) (p < 0.001) and hematocrit (Ht) (p = 0.001) than controls. During GHT, the percentage of anemic patients decreased from 18.4 to 5.4–3.5 and 4.6% after 12 (p = 0.001), 24 (p < 0.001) and 36 months (p < 0.001) of GHT, respectively. In both anemic and non-anemic patients, a significant increase in Hb (p < 0.001, <0.001 and 0.002), RBC (all p < 0.001) and Ht (all p < 0.001) was found after 12, 24 and 36 months of GHT. The Hb levels were significantly correlated with the GH peak after stimulation test (p < 0.001) at baseline and with IGF-I levels at 36 months of GHT (p = 0.002). Conclusions: A significant improvement in erythropoiesis indices occurs during GHT, regardless of any previous presence of anemia.

AB - Objective: Few large-scale studies regarding the impact of GH deficiency (GHD) on hematopoiesis in children have been reported. Our aim was to investigate hematopoiesis indices in a large cohort of GHD children at diagnosis and during GH treatment (GHT) and any correlation with hormonal parameters. Design: Clinical and biochemical data of children with idiopathic GHD at diagnosis and annually up to 36 months of GHT were retrospectively evaluated. Overall, 255 children reached 12 months, 140 children 24 months and 86 children 36 months of follow-up during GHT. Results: At baseline, 18.4% of GHD children and 10.1% of controls showed normocytic anemia. GHD children showed lower hemoglobin (Hb) (p = 0.007), red blood cells (RBC) (p < 0.001) and hematocrit (Ht) (p = 0.001) than controls. During GHT, the percentage of anemic patients decreased from 18.4 to 5.4–3.5 and 4.6% after 12 (p = 0.001), 24 (p < 0.001) and 36 months (p < 0.001) of GHT, respectively. In both anemic and non-anemic patients, a significant increase in Hb (p < 0.001, <0.001 and 0.002), RBC (all p < 0.001) and Ht (all p < 0.001) was found after 12, 24 and 36 months of GHT. The Hb levels were significantly correlated with the GH peak after stimulation test (p < 0.001) at baseline and with IGF-I levels at 36 months of GHT (p = 0.002). Conclusions: A significant improvement in erythropoiesis indices occurs during GHT, regardless of any previous presence of anemia.

KW - Anemia; Children; Growth hormone; Growth hormone deficiency; Growth hormone treatment; Hematopoiesis; Endocrinology, Diabetes and Metabolism; Endocrinology

UR - http://hdl.handle.net/10447/301725

UR - http://www.elsevier-international.com/journals/ghir/

M3 - Article

VL - 42-43

SP - 8

EP - 13

JO - Growth Hormone and IGF Research

JF - Growth Hormone and IGF Research

SN - 1096-6374

ER -