Graphene oxide containing hyaluronic acid based nanogels for the potential treatment of colorectal cancer

Risultato della ricerca: Other

Abstract

Here, we reported the production of graphene oxide (GO) containing nanogels produced by a top-down procedure employing as a starting biomaterial an amino derivative of hyaluronic acid named HA-EDA. This derivative was reacted, in the presence of single layer GO, with α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide-((2-aminoethyl)-carbamate)-divinyl sulfone (PHEA-DVS) employed as a macromolecular crosslinking agent. The so obtained hydrogel was homogenized by ultra-turrax and high pressure homogenizer and nanogels with Z-average of 390 nm and PDI of 0.22 were obtained. These nanogels were employed to incorporate Irinotecan (IT), an antitumor drug used in the treatment of colorectal carcinoma. It was demonstrated that GO gives hyperthermic properties to the nanogels and that this effect influences the release of the antitumor drug. The presence of IT gives to the nanogel cytotoxic effect toward colon cancer cells similar to that of the free drug. It was demonstrated that there is an adjuvant effect between hyperthermia and cytotoxicity of IT that could potentially allow to employ safer amounts of the drug during the treatment. A three-dimensional system for the co-culture of both healthy and tumor cells it was employed to study the possibility to employ the nanogel dispersion for the thermoablation of solid tumors. Obtained results suggest a potential dual mode anticancer activity of the obtained nanosystems.
Lingua originaleEnglish
Numero di pagine1
Stato di pubblicazionePublished - 2017

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irinotecan
Graphite
Hyaluronic Acid
Oxides
Antineoplastic Agents
Tumors
Cells
Derivatives
Nanosystems
Carbamates
Hydrogel
Biocompatible Materials
Cytotoxicity
Cell culture
Pharmaceutical Preparations
Crosslinking
NanoGel

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title = "Graphene oxide containing hyaluronic acid based nanogels for the potential treatment of colorectal cancer",
abstract = "Here, we reported the production of graphene oxide (GO) containing nanogels produced by a top-down procedure employing as a starting biomaterial an amino derivative of hyaluronic acid named HA-EDA. This derivative was reacted, in the presence of single layer GO, with α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide-((2-aminoethyl)-carbamate)-divinyl sulfone (PHEA-DVS) employed as a macromolecular crosslinking agent. The so obtained hydrogel was homogenized by ultra-turrax and high pressure homogenizer and nanogels with Z-average of 390 nm and PDI of 0.22 were obtained. These nanogels were employed to incorporate Irinotecan (IT), an antitumor drug used in the treatment of colorectal carcinoma. It was demonstrated that GO gives hyperthermic properties to the nanogels and that this effect influences the release of the antitumor drug. The presence of IT gives to the nanogel cytotoxic effect toward colon cancer cells similar to that of the free drug. It was demonstrated that there is an adjuvant effect between hyperthermia and cytotoxicity of IT that could potentially allow to employ safer amounts of the drug during the treatment. A three-dimensional system for the co-culture of both healthy and tumor cells it was employed to study the possibility to employ the nanogel dispersion for the thermoablation of solid tumors. Obtained results suggest a potential dual mode anticancer activity of the obtained nanosystems.",
author = "Nicol{\`o} Mauro and Giovanna Pitarresi and Gennara Cavallaro and Calogero Fiorica and Gaetano Giammona",
year = "2017",
language = "English",

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TY - CONF

T1 - Graphene oxide containing hyaluronic acid based nanogels for the potential treatment of colorectal cancer

AU - Mauro, Nicolò

AU - Pitarresi, Giovanna

AU - Cavallaro, Gennara

AU - Fiorica, Calogero

AU - Giammona, Gaetano

PY - 2017

Y1 - 2017

N2 - Here, we reported the production of graphene oxide (GO) containing nanogels produced by a top-down procedure employing as a starting biomaterial an amino derivative of hyaluronic acid named HA-EDA. This derivative was reacted, in the presence of single layer GO, with α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide-((2-aminoethyl)-carbamate)-divinyl sulfone (PHEA-DVS) employed as a macromolecular crosslinking agent. The so obtained hydrogel was homogenized by ultra-turrax and high pressure homogenizer and nanogels with Z-average of 390 nm and PDI of 0.22 were obtained. These nanogels were employed to incorporate Irinotecan (IT), an antitumor drug used in the treatment of colorectal carcinoma. It was demonstrated that GO gives hyperthermic properties to the nanogels and that this effect influences the release of the antitumor drug. The presence of IT gives to the nanogel cytotoxic effect toward colon cancer cells similar to that of the free drug. It was demonstrated that there is an adjuvant effect between hyperthermia and cytotoxicity of IT that could potentially allow to employ safer amounts of the drug during the treatment. A three-dimensional system for the co-culture of both healthy and tumor cells it was employed to study the possibility to employ the nanogel dispersion for the thermoablation of solid tumors. Obtained results suggest a potential dual mode anticancer activity of the obtained nanosystems.

AB - Here, we reported the production of graphene oxide (GO) containing nanogels produced by a top-down procedure employing as a starting biomaterial an amino derivative of hyaluronic acid named HA-EDA. This derivative was reacted, in the presence of single layer GO, with α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide-((2-aminoethyl)-carbamate)-divinyl sulfone (PHEA-DVS) employed as a macromolecular crosslinking agent. The so obtained hydrogel was homogenized by ultra-turrax and high pressure homogenizer and nanogels with Z-average of 390 nm and PDI of 0.22 were obtained. These nanogels were employed to incorporate Irinotecan (IT), an antitumor drug used in the treatment of colorectal carcinoma. It was demonstrated that GO gives hyperthermic properties to the nanogels and that this effect influences the release of the antitumor drug. The presence of IT gives to the nanogel cytotoxic effect toward colon cancer cells similar to that of the free drug. It was demonstrated that there is an adjuvant effect between hyperthermia and cytotoxicity of IT that could potentially allow to employ safer amounts of the drug during the treatment. A three-dimensional system for the co-culture of both healthy and tumor cells it was employed to study the possibility to employ the nanogel dispersion for the thermoablation of solid tumors. Obtained results suggest a potential dual mode anticancer activity of the obtained nanosystems.

UR - http://hdl.handle.net/10447/228486

M3 - Other

ER -