AbstractObjectivesTo evaluate the efficacy of dienogest + estradiol valerate (E2V) and gonadotrophin-releasing hormone analogue (GnRH-a) in reducing recurrence of pain in patients with chronic pelvic pain due to laparoscopically diagnosed and treated endometriosis.DesignMulti-center, prospective, randomized study.SettingThree university departments of obstetrics and gynecology in Italy.PopulationSeventy-eight women who underwent laparoscopic surgery for endometriosis combined with chronic pelvic pain.MethodsPost-operative administration of dienogest + E2V for 9 months (group 1) or GnRH-a monthly for 6 months (group 2).Main outcome measuresA visual analogue scale was used to test intensity of pain before laparoscopic surgery at 3, 6 and 9 months of follow up. A questionnaire to investigate quality of life was administered before surgery and at 9 months of follow up.ResultsThe visual analogue scale score did not show any significant differences between the two groups (p = 0.417). The questionnaire showed an increase of scores for all women compared with pre-surgery values, demonstrating a marked improvement in quality of life and health-related satisfaction with both treatments. No significant differences were found between the groups. The rate of apparent endometriosis recurrence was 10.8% in group 1 and 13.7% in group 2 (p = 0.962).ConclusionBoth therapies seemed equally efficacious in preventing endometriosis-related chronic pelvic pain recurrence in the first 9 months of follow-up.
|Numero di pagine||9|
|Rivista||Acta Obstetricia et Gynecologica Scandinavica|
|Stato di pubblicazione||Published - 2015|
All Science Journal Classification (ASJC) codes
- Obstetrics and Gynaecology