Glycaemic variability (measured by 48h continous glucose monitoring) in subjects with metabolic syndrome, with ot withoout diabetes,is indipendently associated with IL-6 bood concentrations

Buscemi S; Verga S; Cottone S; Azzolina V; Buscemi B; Gioia D; Tranchina Mr; Cerasola G

Risultato della ricerca: Paper

Abstract

Postprandial hyperglycaemia induces endothelial dysfunction thus contributing to the appearance of atherosclerotic lesions and to the high cardiovascular risk of diabetic subjects. Subjects who develop diabetes have an increased cardiovascular risk even before the appearance of diabetes. Insulin resistant subjects with metabolic syndrome (MS) are at both high cardiovascular and diabetes risk and it cannot be excluded that higher postprandial glycaemic excursions might induce endothelial dysfunction in this condition. Furthermore, adipose tissue is known to release factors (adipokines) that are able to influence both insulin sensitivity and endothelial function. The glycaemic variability is an interesting measurement concerning the frequency of hyperglycaemic and hypoglycaemic excursions and it might contribute to describe the glycaemic control independently of fasting plasma glucose and glycated haemoglobin. Recently, continuous glucose monitoring systems have been developed that are able to measure interstitial glucose levels every 3 min for up to 2 days thus allowing a more accurate detection of both daily glucose load and variability.
Lingua originaleEnglish
Stato di pubblicazionePublished - 2007

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Interleukin-6
Glucose
Adipokines
Glycosylated Hemoglobin A
Hypoglycemic Agents
Hyperglycemia
Insulin Resistance
Adipose Tissue
Fasting
Insulin

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Glycaemic variability (measured by 48h continous glucose monitoring) in subjects with metabolic syndrome, with ot withoout diabetes,is indipendently associated with IL-6 bood concentrations. / Buscemi S; Verga S; Cottone S; Azzolina V; Buscemi B; Gioia D; Tranchina Mr; Cerasola G.

2007.

Risultato della ricerca: Paper

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title = "Glycaemic variability (measured by 48h continous glucose monitoring) in subjects with metabolic syndrome, with ot withoout diabetes,is indipendently associated with IL-6 bood concentrations",
abstract = "Postprandial hyperglycaemia induces endothelial dysfunction thus contributing to the appearance of atherosclerotic lesions and to the high cardiovascular risk of diabetic subjects. Subjects who develop diabetes have an increased cardiovascular risk even before the appearance of diabetes. Insulin resistant subjects with metabolic syndrome (MS) are at both high cardiovascular and diabetes risk and it cannot be excluded that higher postprandial glycaemic excursions might induce endothelial dysfunction in this condition. Furthermore, adipose tissue is known to release factors (adipokines) that are able to influence both insulin sensitivity and endothelial function. The glycaemic variability is an interesting measurement concerning the frequency of hyperglycaemic and hypoglycaemic excursions and it might contribute to describe the glycaemic control independently of fasting plasma glucose and glycated haemoglobin. Recently, continuous glucose monitoring systems have been developed that are able to measure interstitial glucose levels every 3 min for up to 2 days thus allowing a more accurate detection of both daily glucose load and variability.",
author = "{Buscemi S; Verga S; Cottone S; Azzolina V; Buscemi B; Gioia D; Tranchina Mr; Cerasola G} and Giovanni Cerasola and Salvatore Verga and Silvio Buscemi and Vitalba Azzolina",
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T1 - Glycaemic variability (measured by 48h continous glucose monitoring) in subjects with metabolic syndrome, with ot withoout diabetes,is indipendently associated with IL-6 bood concentrations

AU - Buscemi S; Verga S; Cottone S; Azzolina V; Buscemi B; Gioia D; Tranchina Mr; Cerasola G

AU - Cerasola, Giovanni

AU - Verga, Salvatore

AU - Buscemi, Silvio

AU - Azzolina, Vitalba

PY - 2007

Y1 - 2007

N2 - Postprandial hyperglycaemia induces endothelial dysfunction thus contributing to the appearance of atherosclerotic lesions and to the high cardiovascular risk of diabetic subjects. Subjects who develop diabetes have an increased cardiovascular risk even before the appearance of diabetes. Insulin resistant subjects with metabolic syndrome (MS) are at both high cardiovascular and diabetes risk and it cannot be excluded that higher postprandial glycaemic excursions might induce endothelial dysfunction in this condition. Furthermore, adipose tissue is known to release factors (adipokines) that are able to influence both insulin sensitivity and endothelial function. The glycaemic variability is an interesting measurement concerning the frequency of hyperglycaemic and hypoglycaemic excursions and it might contribute to describe the glycaemic control independently of fasting plasma glucose and glycated haemoglobin. Recently, continuous glucose monitoring systems have been developed that are able to measure interstitial glucose levels every 3 min for up to 2 days thus allowing a more accurate detection of both daily glucose load and variability.

AB - Postprandial hyperglycaemia induces endothelial dysfunction thus contributing to the appearance of atherosclerotic lesions and to the high cardiovascular risk of diabetic subjects. Subjects who develop diabetes have an increased cardiovascular risk even before the appearance of diabetes. Insulin resistant subjects with metabolic syndrome (MS) are at both high cardiovascular and diabetes risk and it cannot be excluded that higher postprandial glycaemic excursions might induce endothelial dysfunction in this condition. Furthermore, adipose tissue is known to release factors (adipokines) that are able to influence both insulin sensitivity and endothelial function. The glycaemic variability is an interesting measurement concerning the frequency of hyperglycaemic and hypoglycaemic excursions and it might contribute to describe the glycaemic control independently of fasting plasma glucose and glycated haemoglobin. Recently, continuous glucose monitoring systems have been developed that are able to measure interstitial glucose levels every 3 min for up to 2 days thus allowing a more accurate detection of both daily glucose load and variability.

UR - http://hdl.handle.net/10447/32092

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