GLP-2: What do we know? What are we going to discover?

Antonella Amato, Sara Baldassano, Sara Baldassano, Antonella Amato

Risultato della ricerca: Article

20 Citazioni (Scopus)

Abstract

Glucagon-like peptide 2 [GLP-2] is a 33-amino acid peptide released from themucosal enteroendocrine L-cells ofthe intestine. The actions of GLP-2 are transduced by the GLP-2 receptor [GLP-2R], which is localized in theneurons of the enteric nervous system but not in the intestinal epithelium, indicating an indirect mechanismof action. GLP-2 is well known for its trophic role within the intestine and interest in GLP-2 is now revivingbased on the approval of the GLP-2R agonist for treatment of short bowel syndrome [SBS]. Recently it alsoseems to be involved in glucose homeostasis.The aimof this reviewis to outline the importance of neuroendocrine peptides, specifically of GLP-2 in the entericmodulation of the gastrointestinal function and to focus on new works in order to present an innovative pictureof GLP-2.
Lingua originaleEnglish
Numero di pagine5
RivistaRegulatory Peptides
Volume1
Stato di pubblicazionePublished - 2014

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Glucagon-Like Peptide 2
Enteroendocrine Cells
Short Bowel Syndrome
Enteric Nervous System
Peptides
Neurology
Intestinal Mucosa
Intestines
Homeostasis
Amino Acids
Glucose

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience

Cita questo

GLP-2: What do we know? What are we going to discover? / Amato, Antonella; Baldassano, Sara; Baldassano, Sara; Amato, Antonella.

In: Regulatory Peptides, Vol. 1, 2014.

Risultato della ricerca: Article

Amato, A, Baldassano, S, Baldassano, S & Amato, A 2014, 'GLP-2: What do we know? What are we going to discover?', Regulatory Peptides, vol. 1.
Amato A, Baldassano S, Baldassano S, Amato A. GLP-2: What do we know? What are we going to discover? Regulatory Peptides. 2014;1.
Amato, Antonella ; Baldassano, Sara ; Baldassano, Sara ; Amato, Antonella. / GLP-2: What do we know? What are we going to discover?. In: Regulatory Peptides. 2014 ; Vol. 1.
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AB - Glucagon-like peptide 2 [GLP-2] is a 33-amino acid peptide released from themucosal enteroendocrine L-cells ofthe intestine. The actions of GLP-2 are transduced by the GLP-2 receptor [GLP-2R], which is localized in theneurons of the enteric nervous system but not in the intestinal epithelium, indicating an indirect mechanismof action. GLP-2 is well known for its trophic role within the intestine and interest in GLP-2 is now revivingbased on the approval of the GLP-2R agonist for treatment of short bowel syndrome [SBS]. Recently it alsoseems to be involved in glucose homeostasis.The aimof this reviewis to outline the importance of neuroendocrine peptides, specifically of GLP-2 in the entericmodulation of the gastrointestinal function and to focus on new works in order to present an innovative pictureof GLP-2.

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