Abstract
Glucagon-like peptide 2 [GLP-2] is a 33-amino acid peptide released from themucosal enteroendocrine L-cells ofthe intestine. The actions of GLP-2 are transduced by the GLP-2 receptor [GLP-2R], which is localized in theneurons of the enteric nervous system but not in the intestinal epithelium, indicating an indirect mechanismof action. GLP-2 is well known for its trophic role within the intestine and interest in GLP-2 is now revivingbased on the approval of the GLP-2R agonist for treatment of short bowel syndrome [SBS]. Recently it alsoseems to be involved in glucose homeostasis.The aimof this reviewis to outline the importance of neuroendocrine peptides, specifically of GLP-2 in the entericmodulation of the gastrointestinal function and to focus on new works in order to present an innovative pictureof GLP-2.
| Lingua originale | English |
|---|---|
| Numero di pagine | 5 |
| Rivista | Regulatory Peptides |
| Volume | 1 |
| Stato di pubblicazione | Published - 2014 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Physiology
- Endocrinology
- Clinical Biochemistry
- Cellular and Molecular Neuroscience
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Amato, A., Baldassano, S., Baldassano, S., & Amato, A. (2014). GLP-2: What do we know? What are we going to discover? Regulatory Peptides, 1.