Global diversity in the TAS2R38 bitter taste receptor: revisiting a classic evolutionary PROPosal

Fabio Caradonna, Paolo Gasparini, Massimo Mezzavilla, Luca Pagani, Antonietta Robino, Roberto Barale, Maura Carrai, Davide S. Risso, Dennis Drayna, Donata Luiselli, Sergio Tofanelli, Stephen Wooding, Gabriella Morini, Daniele Campa

Risultato della ricerca: Articlepeer review

36 Citazioni (Scopus)


The ability to taste phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) is a polymorphic trait mediated by the TAS2R38 bitter taste receptor gene. It has long been hypothesized that global genetic diversity at this locus evolved under pervasive pressures from balancing natural selection. However, recent high-resolution population genetic studies of TAS2Rs suggest that demographic events have played a critical role in the evolution of these genes. We here utilized the largest TAS2R38 database yet analyzed, consisting of 5,589 individuals from 105 populations, to examine natural selection, haplotype frequencies and linkage disequilibrium to estimate the effects of both selection and demography on contemporary patterns of variation at this locus. We found signs of an ancient balancing selection acting on this gene but no post Out-Of-Africa departures from neutrality, implying that the current observed patterns of variation can be predominantly explained by demographic, rather than selective events. In addition, we found signatures of ancient selective forces acting on different African TAS2R38 haplotypes. Collectively our results provide evidence for a relaxation of recent selective forces acting on this gene and a revised hypothesis for the origins of the present-day worldwide distribution of TAS2R38 haplotypes
Lingua originaleEnglish
pagine (da-a)1-8
Numero di pagine8
RivistaScientific Reports
Stato di pubblicazionePublished - 2016

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