Genotypic and phenotypic aspects of longevity: results from a Sicilian survey and implication for the prevention and the treatment of age-related diseases

Calogero Caruso, Giulia Accardi, Sonya Vasto, Anna Aiello, Laura Cristaldi, Mattia Emanuela Ligotti, Walter Mazzucco, Giuseppina Candore, Caterina Maria Gambino, Sonya Vasto, Rosanna Cusimano, Danilo Di Bona, Damiano Galimberti, Laura Cristaldi, Giovanni Duro, Calogero Caruso, Danilo Di Bona, Giovanni Duro, Rosanna Cusimano, Stefano Aprile

Risultato della ricerca: Article

1 Citazione (Scopus)

Abstract

BACKGROUND:It is well known that long living individuals are a model of successful ageing and that the identification of both genetic variants and environmental factors that predispose to long and health life is of tremendous interest for translational medicine.METHODS:We present the preliminary findings obtained from an ongoing study on longevity conducted on a sample of Sicilian long lived individuals.RESULTS:We review the characteristics of longevity in Sicily, taking into account life style, environment, genetics, hematochemical values, body composition and immunophenotype. In addition, we discuss the possible implications of our data for the prevention and/or treatment of age-related diseases.CONCLUSION:As widely discussed in this review, the explanation of the role of genetics and lifestyle in longevity can provide important information on how to develop drugs and / or behaviours that can slow down or delay ageing. Thus, it will be possible to understand, through a "positive biology" approach, how to prevent and/or reduce elderly frailty and disability.
Lingua originaleEnglish
pagine (da-a)228-235
Numero di pagine8
RivistaDefault journal
Volume25
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cita questo

Genotypic and phenotypic aspects of longevity: results from a Sicilian survey and implication for the prevention and the treatment of age-related diseases. / Caruso, Calogero; Accardi, Giulia; Vasto, Sonya; Aiello, Anna; Cristaldi, Laura; Ligotti, Mattia Emanuela; Mazzucco, Walter; Candore, Giuseppina; Gambino, Caterina Maria; Vasto, Sonya; Cusimano, Rosanna; Bona, Danilo Di; Galimberti, Damiano; Cristaldi, Laura; Duro, Giovanni; Caruso, Calogero; Di Bona, Danilo; Duro, Giovanni; Cusimano, Rosanna; Aprile, Stefano.

In: Default journal, Vol. 25, 2019, pag. 228-235.

Risultato della ricerca: Article

Caruso, Calogero ; Accardi, Giulia ; Vasto, Sonya ; Aiello, Anna ; Cristaldi, Laura ; Ligotti, Mattia Emanuela ; Mazzucco, Walter ; Candore, Giuseppina ; Gambino, Caterina Maria ; Vasto, Sonya ; Cusimano, Rosanna ; Bona, Danilo Di ; Galimberti, Damiano ; Cristaldi, Laura ; Duro, Giovanni ; Caruso, Calogero ; Di Bona, Danilo ; Duro, Giovanni ; Cusimano, Rosanna ; Aprile, Stefano. / Genotypic and phenotypic aspects of longevity: results from a Sicilian survey and implication for the prevention and the treatment of age-related diseases. In: Default journal. 2019 ; Vol. 25. pagg. 228-235.
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abstract = "BACKGROUND:It is well known that long living individuals are a model of successful ageing and that the identification of both genetic variants and environmental factors that predispose to long and health life is of tremendous interest for translational medicine.METHODS:We present the preliminary findings obtained from an ongoing study on longevity conducted on a sample of Sicilian long lived individuals.RESULTS:We review the characteristics of longevity in Sicily, taking into account life style, environment, genetics, hematochemical values, body composition and immunophenotype. In addition, we discuss the possible implications of our data for the prevention and/or treatment of age-related diseases.CONCLUSION:As widely discussed in this review, the explanation of the role of genetics and lifestyle in longevity can provide important information on how to develop drugs and / or behaviours that can slow down or delay ageing. Thus, it will be possible to understand, through a {"}positive biology{"} approach, how to prevent and/or reduce elderly frailty and disability.",
author = "Calogero Caruso and Giulia Accardi and Sonya Vasto and Anna Aiello and Laura Cristaldi and Ligotti, {Mattia Emanuela} and Walter Mazzucco and Giuseppina Candore and Gambino, {Caterina Maria} and Sonya Vasto and Rosanna Cusimano and Bona, {Danilo Di} and Damiano Galimberti and Laura Cristaldi and Giovanni Duro and Calogero Caruso and {Di Bona}, Danilo and Giovanni Duro and Rosanna Cusimano and Stefano Aprile",
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TY - JOUR

T1 - Genotypic and phenotypic aspects of longevity: results from a Sicilian survey and implication for the prevention and the treatment of age-related diseases

AU - Caruso, Calogero

AU - Accardi, Giulia

AU - Vasto, Sonya

AU - Aiello, Anna

AU - Cristaldi, Laura

AU - Ligotti, Mattia Emanuela

AU - Mazzucco, Walter

AU - Candore, Giuseppina

AU - Gambino, Caterina Maria

AU - Vasto, Sonya

AU - Cusimano, Rosanna

AU - Bona, Danilo Di

AU - Galimberti, Damiano

AU - Cristaldi, Laura

AU - Duro, Giovanni

AU - Caruso, Calogero

AU - Di Bona, Danilo

AU - Duro, Giovanni

AU - Cusimano, Rosanna

AU - Aprile, Stefano

PY - 2019

Y1 - 2019

N2 - BACKGROUND:It is well known that long living individuals are a model of successful ageing and that the identification of both genetic variants and environmental factors that predispose to long and health life is of tremendous interest for translational medicine.METHODS:We present the preliminary findings obtained from an ongoing study on longevity conducted on a sample of Sicilian long lived individuals.RESULTS:We review the characteristics of longevity in Sicily, taking into account life style, environment, genetics, hematochemical values, body composition and immunophenotype. In addition, we discuss the possible implications of our data for the prevention and/or treatment of age-related diseases.CONCLUSION:As widely discussed in this review, the explanation of the role of genetics and lifestyle in longevity can provide important information on how to develop drugs and / or behaviours that can slow down or delay ageing. Thus, it will be possible to understand, through a "positive biology" approach, how to prevent and/or reduce elderly frailty and disability.

AB - BACKGROUND:It is well known that long living individuals are a model of successful ageing and that the identification of both genetic variants and environmental factors that predispose to long and health life is of tremendous interest for translational medicine.METHODS:We present the preliminary findings obtained from an ongoing study on longevity conducted on a sample of Sicilian long lived individuals.RESULTS:We review the characteristics of longevity in Sicily, taking into account life style, environment, genetics, hematochemical values, body composition and immunophenotype. In addition, we discuss the possible implications of our data for the prevention and/or treatment of age-related diseases.CONCLUSION:As widely discussed in this review, the explanation of the role of genetics and lifestyle in longevity can provide important information on how to develop drugs and / or behaviours that can slow down or delay ageing. Thus, it will be possible to understand, through a "positive biology" approach, how to prevent and/or reduce elderly frailty and disability.

UR - http://hdl.handle.net/10447/356469

M3 - Article

VL - 25

SP - 228

EP - 235

JO - Default journal

JF - Default journal

ER -