Genome-wide scan of fat-tail sheep identifies signals of selection for fat deposition and adaptation

Salvatore Mastrangelo, Baldassare Portolano, Ciani, Latairish, Ahbara, Moioli, Pilla

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7 Citazioni (Scopus)

Abstract

Fat tail in sheep represents a valuable energy reserve for facing future climate changes. The identificationof genes with a role in the fat-tail phenotype may contribute to understanding the physiology of fat deposition and themechanisms of adaptation. Genotypic data obtained with the OvineSNP50K array in 13 thin-tail sheep breeds fromItaly were used to identify selection signatures of fat tail through pairwise thin- versus fat-tail sheep breedcomparisons, with the following fat-tail breeds of the Mediterranean area: two unique Italian fat-tail breeds(Barbaresca and Laticauda), a Barbary sheep breed from Libya, Ossimi breed from Egypt, Cyprus Fat-Tail andChios from the Greek islands Cyprus and Chios, respectively. Fst and c2 values obtained for >40 000 polymorphicmarkers allowed confirmation of 12 fat-tail associations that were previously reported in Chinese and Iranian breeds.Two of these signals – on OAR 7 and OAR 13 – are in the proximity of two genes – VRTN and BMP2 – with a role inthe variation of vertebral number and in fat-tail formation respectively. Two identified signals on OAR 6 and OAR 15encompass two genes, PDGFRA and PDGFD, involved in the differentiation of preadipocytes. Further signalsdetected herein were reported in Chinese sheep as signatures of adaptation to desert areas. For several of the detectedassociations, the known role in either fat deposition or adaptation, thus contributing to revealing the molecular basisunderlying mechanisms of energy storage and climate adaptation.
Lingua originaleEnglish
Numero di pagine14
RivistaAnimal Production Science
Stato di pubblicazionePublished - 2018

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All Science Journal Classification (ASJC) codes

  • Food Science
  • Animal Science and Zoology

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