Genome-wide meta-analyses identify three loci associated with primary biliarycirrhosis.

Pier Luigi Almasio

Genome-wide meta-analyses identify three loci associated with primary biliarycirrhosis.

Pier Luigi Almasio

Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza “G. D’Alessandro”

Risultato della ricerca: Article › peer review

330 Citazioni (Scopus)

Abstract

A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 × 10–11, odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 × 10–10, OR = 1.63) and 17q12-21 (P = 1.7 × 10–10, OR = 1.38).

Lingua originale	English
pagine (da-a)	658-
Numero di pagine	3
Rivista	Nature Genetics
Volume	42
Stato di pubblicazione	Published - 2010

All Science Journal Classification (ASJC) codes

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title = "Genome-wide meta-analyses identify three loci associated with primary biliarycirrhosis.",

abstract = "A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 × 10–11, odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 × 10–10, OR = 1.63) and 17q12-21 (P = 1.7 × 10–10, OR = 1.38).",

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year = "2010",

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journal = "Nature Genetics",

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AU - Almasio, Pier Luigi

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N2 - A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 × 10–11, odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 × 10–10, OR = 1.63) and 17q12-21 (P = 1.7 × 10–10, OR = 1.38).

AB - A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 × 10–11, odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 × 10–10, OR = 1.63) and 17q12-21 (P = 1.7 × 10–10, OR = 1.38).

KW - Primary biliary cirrhosis

UR - http://hdl.handle.net/10447/61108

M3 - Article

SN - 1061-4036

VL - 42

SP - 658-

JO - Nature Genetics

JF - Nature Genetics

ER -

Genome-wide meta-analyses identify three loci associated with primary biliarycirrhosis.

Abstract

All Science Journal Classification (ASJC) codes

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