Genome-wide meta-analyses identify three loci associated with primary biliarycirrhosis.

Risultato della ricerca: Articlepeer review

298 Citazioni (Scopus)

Abstract

A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 × 10–11, odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 × 10–10, OR = 1.63) and 17q12-21 (P = 1.7 × 10–10, OR = 1.38).
Lingua originaleEnglish
pagine (da-a)658-
Numero di pagine3
RivistaNature Genetics
Volume42
Stato di pubblicazionePublished - 2010

All Science Journal Classification (ASJC) codes

  • Genetics

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