Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome.

Claudio Tripodo, Ivo Kwee, Cassio P. De Campos, Paola M. V. Rancoita, Ekaterina Chigrinova, Michael Mian, Francesco Bertoni, Stephan Dirnhofer, Catherine Thieblemont, Alessandra Tucci, Gianluca Gaidano, Govind Bhagat, Emanuele Zucca, Maria Grazia Tibiletti, Silvia Govi, Francesco Forconi, Silvia Uccella, Manuela Mollejo, Luca Arcaini, Vincenzo CanzonieriUrban Novak, Roberto Marasca, Valter Gattei, Silvia Franceschetti, Miguel A. Piris, Claudio Doglioni, Luca Baldini, Maurilio Ponzoni, Andrés J. M. Ferreri, Fabio Facchetti, Randy D. Gascoyne, Jean Soulier, Riccardo Dalla Favera, Franco Cavalli, Andrea Rinaldi

Risultato della ricerca: Article

120 Citazioni (Scopus)

Abstract

Marginal zone B-cell lymphomas (MZLs) have been divided into 3 distinct subtypes (extranodal MZLs of mucosa-associated lymphoid tissue [MALT] type, nodal MZLs, and splenic MZLs). Nevertheless, the relationship between the subtypes is still unclear. We performed a comprehensive analysis of genomic DNA copy number changes in a very large series of MZL cases with the aim of addressing this question. Samples from 218 MZL patients (25 nodal, 57 MALT, 134 splenic, and 2 not better specified MZLs) were analyzed with the Affymetrix Human Mapping 250K SNP arrays, and the data combined with matched gene expression in 33 of 218 cases. MALT lymphoma presented significantly more frequently gains at 3p, 6p, 18p, and del(6q23) (TNFAIP3/A20), whereas splenic MZLs was associated with del(7q31), del(8p). Nodal MZLs did not show statistically significant differences compared with MALT lymphoma while lacking the splenic MZLs-related 7q losses. Gains of 3q and 18q were common to all 3 subtypes. del(8p) was often present together with del(17p) (TP53). Although del(17p) did not determine a worse outcome and del(8p) was only of borderline significance, the presence of both deletions had a highly significant negative impact on the outcome of splenic MZLs.
Lingua originaleEnglish
pagine (da-a)1595-1604
Numero di pagine10
RivistaBlood
Volume117
Stato di pubblicazionePublished - 2011

Fingerprint

Marginal Zone B-Cell Lymphoma
DNA Fingerprinting
Lymphoma
Genes
Genome
Tissue
DNA
Gene expression
Cells
Mucous Membrane
DNA Copy Number Variations
Lymphoid Tissue
Single Nucleotide Polymorphism

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cita questo

Tripodo, C., Kwee, I., De Campos, C. P., Rancoita, P. M. V., Chigrinova, E., Mian, M., ... Rinaldi, A. (2011). Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome. Blood, 117, 1595-1604.

Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome. / Tripodo, Claudio; Kwee, Ivo; De Campos, Cassio P.; Rancoita, Paola M. V.; Chigrinova, Ekaterina; Mian, Michael; Bertoni, Francesco; Dirnhofer, Stephan; Thieblemont, Catherine; Tucci, Alessandra; Gaidano, Gianluca; Bhagat, Govind; Zucca, Emanuele; Tibiletti, Maria Grazia; Govi, Silvia; Forconi, Francesco; Uccella, Silvia; Mollejo, Manuela; Arcaini, Luca; Canzonieri, Vincenzo; Novak, Urban; Marasca, Roberto; Gattei, Valter; Franceschetti, Silvia; Piris, Miguel A.; Doglioni, Claudio; Baldini, Luca; Ponzoni, Maurilio; Ferreri, Andrés J. M.; Facchetti, Fabio; Gascoyne, Randy D.; Soulier, Jean; Favera, Riccardo Dalla; Cavalli, Franco; Rinaldi, Andrea.

In: Blood, Vol. 117, 2011, pag. 1595-1604.

Risultato della ricerca: Article

Tripodo, C, Kwee, I, De Campos, CP, Rancoita, PMV, Chigrinova, E, Mian, M, Bertoni, F, Dirnhofer, S, Thieblemont, C, Tucci, A, Gaidano, G, Bhagat, G, Zucca, E, Tibiletti, MG, Govi, S, Forconi, F, Uccella, S, Mollejo, M, Arcaini, L, Canzonieri, V, Novak, U, Marasca, R, Gattei, V, Franceschetti, S, Piris, MA, Doglioni, C, Baldini, L, Ponzoni, M, Ferreri, AJM, Facchetti, F, Gascoyne, RD, Soulier, J, Favera, RD, Cavalli, F & Rinaldi, A 2011, 'Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome.', Blood, vol. 117, pagg. 1595-1604.
Tripodo, Claudio ; Kwee, Ivo ; De Campos, Cassio P. ; Rancoita, Paola M. V. ; Chigrinova, Ekaterina ; Mian, Michael ; Bertoni, Francesco ; Dirnhofer, Stephan ; Thieblemont, Catherine ; Tucci, Alessandra ; Gaidano, Gianluca ; Bhagat, Govind ; Zucca, Emanuele ; Tibiletti, Maria Grazia ; Govi, Silvia ; Forconi, Francesco ; Uccella, Silvia ; Mollejo, Manuela ; Arcaini, Luca ; Canzonieri, Vincenzo ; Novak, Urban ; Marasca, Roberto ; Gattei, Valter ; Franceschetti, Silvia ; Piris, Miguel A. ; Doglioni, Claudio ; Baldini, Luca ; Ponzoni, Maurilio ; Ferreri, Andrés J. M. ; Facchetti, Fabio ; Gascoyne, Randy D. ; Soulier, Jean ; Favera, Riccardo Dalla ; Cavalli, Franco ; Rinaldi, Andrea. / Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome. In: Blood. 2011 ; Vol. 117. pagg. 1595-1604.
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title = "Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome.",
abstract = "Marginal zone B-cell lymphomas (MZLs) have been divided into 3 distinct subtypes (extranodal MZLs of mucosa-associated lymphoid tissue [MALT] type, nodal MZLs, and splenic MZLs). Nevertheless, the relationship between the subtypes is still unclear. We performed a comprehensive analysis of genomic DNA copy number changes in a very large series of MZL cases with the aim of addressing this question. Samples from 218 MZL patients (25 nodal, 57 MALT, 134 splenic, and 2 not better specified MZLs) were analyzed with the Affymetrix Human Mapping 250K SNP arrays, and the data combined with matched gene expression in 33 of 218 cases. MALT lymphoma presented significantly more frequently gains at 3p, 6p, 18p, and del(6q23) (TNFAIP3/A20), whereas splenic MZLs was associated with del(7q31), del(8p). Nodal MZLs did not show statistically significant differences compared with MALT lymphoma while lacking the splenic MZLs-related 7q losses. Gains of 3q and 18q were common to all 3 subtypes. del(8p) was often present together with del(17p) (TP53). Although del(17p) did not determine a worse outcome and del(8p) was only of borderline significance, the presence of both deletions had a highly significant negative impact on the outcome of splenic MZLs.",
author = "Claudio Tripodo and Ivo Kwee and {De Campos}, {Cassio P.} and Rancoita, {Paola M. V.} and Ekaterina Chigrinova and Michael Mian and Francesco Bertoni and Stephan Dirnhofer and Catherine Thieblemont and Alessandra Tucci and Gianluca Gaidano and Govind Bhagat and Emanuele Zucca and Tibiletti, {Maria Grazia} and Silvia Govi and Francesco Forconi and Silvia Uccella and Manuela Mollejo and Luca Arcaini and Vincenzo Canzonieri and Urban Novak and Roberto Marasca and Valter Gattei and Silvia Franceschetti and Piris, {Miguel A.} and Claudio Doglioni and Luca Baldini and Maurilio Ponzoni and Ferreri, {Andr{\'e}s J. M.} and Fabio Facchetti and Gascoyne, {Randy D.} and Jean Soulier and Favera, {Riccardo Dalla} and Franco Cavalli and Andrea Rinaldi",
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TY - JOUR

T1 - Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome.

AU - Tripodo, Claudio

AU - Kwee, Ivo

AU - De Campos, Cassio P.

AU - Rancoita, Paola M. V.

AU - Chigrinova, Ekaterina

AU - Mian, Michael

AU - Bertoni, Francesco

AU - Dirnhofer, Stephan

AU - Thieblemont, Catherine

AU - Tucci, Alessandra

AU - Gaidano, Gianluca

AU - Bhagat, Govind

AU - Zucca, Emanuele

AU - Tibiletti, Maria Grazia

AU - Govi, Silvia

AU - Forconi, Francesco

AU - Uccella, Silvia

AU - Mollejo, Manuela

AU - Arcaini, Luca

AU - Canzonieri, Vincenzo

AU - Novak, Urban

AU - Marasca, Roberto

AU - Gattei, Valter

AU - Franceschetti, Silvia

AU - Piris, Miguel A.

AU - Doglioni, Claudio

AU - Baldini, Luca

AU - Ponzoni, Maurilio

AU - Ferreri, Andrés J. M.

AU - Facchetti, Fabio

AU - Gascoyne, Randy D.

AU - Soulier, Jean

AU - Favera, Riccardo Dalla

AU - Cavalli, Franco

AU - Rinaldi, Andrea

PY - 2011

Y1 - 2011

N2 - Marginal zone B-cell lymphomas (MZLs) have been divided into 3 distinct subtypes (extranodal MZLs of mucosa-associated lymphoid tissue [MALT] type, nodal MZLs, and splenic MZLs). Nevertheless, the relationship between the subtypes is still unclear. We performed a comprehensive analysis of genomic DNA copy number changes in a very large series of MZL cases with the aim of addressing this question. Samples from 218 MZL patients (25 nodal, 57 MALT, 134 splenic, and 2 not better specified MZLs) were analyzed with the Affymetrix Human Mapping 250K SNP arrays, and the data combined with matched gene expression in 33 of 218 cases. MALT lymphoma presented significantly more frequently gains at 3p, 6p, 18p, and del(6q23) (TNFAIP3/A20), whereas splenic MZLs was associated with del(7q31), del(8p). Nodal MZLs did not show statistically significant differences compared with MALT lymphoma while lacking the splenic MZLs-related 7q losses. Gains of 3q and 18q were common to all 3 subtypes. del(8p) was often present together with del(17p) (TP53). Although del(17p) did not determine a worse outcome and del(8p) was only of borderline significance, the presence of both deletions had a highly significant negative impact on the outcome of splenic MZLs.

AB - Marginal zone B-cell lymphomas (MZLs) have been divided into 3 distinct subtypes (extranodal MZLs of mucosa-associated lymphoid tissue [MALT] type, nodal MZLs, and splenic MZLs). Nevertheless, the relationship between the subtypes is still unclear. We performed a comprehensive analysis of genomic DNA copy number changes in a very large series of MZL cases with the aim of addressing this question. Samples from 218 MZL patients (25 nodal, 57 MALT, 134 splenic, and 2 not better specified MZLs) were analyzed with the Affymetrix Human Mapping 250K SNP arrays, and the data combined with matched gene expression in 33 of 218 cases. MALT lymphoma presented significantly more frequently gains at 3p, 6p, 18p, and del(6q23) (TNFAIP3/A20), whereas splenic MZLs was associated with del(7q31), del(8p). Nodal MZLs did not show statistically significant differences compared with MALT lymphoma while lacking the splenic MZLs-related 7q losses. Gains of 3q and 18q were common to all 3 subtypes. del(8p) was often present together with del(17p) (TP53). Although del(17p) did not determine a worse outcome and del(8p) was only of borderline significance, the presence of both deletions had a highly significant negative impact on the outcome of splenic MZLs.

UR - http://hdl.handle.net/10447/60711

M3 - Article

VL - 117

SP - 1595

EP - 1604

JO - Blood

JF - Blood

SN - 0006-4971

ER -