TY - JOUR
T1 - Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome.
AU - Tripodo, Claudio
AU - Kwee, Ivo
AU - De Campos, Cassio P.
AU - Rancoita, Paola M. V.
AU - Chigrinova, Ekaterina
AU - Mian, Michael
AU - Bertoni, Francesco
AU - Dirnhofer, Stephan
AU - Thieblemont, Catherine
AU - Tucci, Alessandra
AU - Piris, Miguel A.
AU - Gaidano, Gianluca
AU - Bhagat, Govind
AU - Zucca, Emanuele
AU - Tibiletti, Maria Grazia
AU - Govi, Silvia
AU - Forconi, Francesco
AU - Uccella, Silvia
AU - Mollejo, Manuela
AU - Arcaini, Luca
AU - Canzonieri, Vincenzo
AU - Novak, Urban
AU - Marasca, Roberto
AU - Gattei, Valter
AU - Franceschetti, Silvia
AU - Piris, Miguel A.
AU - Doglioni, Claudio
AU - Baldini, Luca
AU - Ponzoni, Maurilio
AU - Ferreri, Andrés J. M.
AU - Facchetti, Fabio
AU - Gascoyne, Randy D.
AU - Soulier, Jean
AU - Favera, Riccardo Dalla
AU - Cavalli, Franco
AU - Rinaldi, Andrea
PY - 2011
Y1 - 2011
N2 - Marginal zone B-cell lymphomas (MZLs) have been divided into 3 distinct subtypes (extranodal MZLs of mucosa-associated lymphoid tissue [MALT] type, nodal MZLs, and splenic MZLs). Nevertheless, the relationship between the subtypes is still unclear. We performed a comprehensive analysis of genomic DNA copy number changes in a very large series of MZL cases with the aim of addressing this question. Samples from 218 MZL patients (25 nodal, 57 MALT, 134 splenic, and 2 not better specified MZLs) were analyzed with the Affymetrix Human Mapping 250K SNP arrays, and the data combined with matched gene expression in 33 of 218 cases. MALT lymphoma presented significantly more frequently gains at 3p, 6p, 18p, and del(6q23) (TNFAIP3/A20), whereas splenic MZLs was associated with del(7q31), del(8p). Nodal MZLs did not show statistically significant differences compared with MALT lymphoma while lacking the splenic MZLs-related 7q losses. Gains of 3q and 18q were common to all 3 subtypes. del(8p) was often present together with del(17p) (TP53). Although del(17p) did not determine a worse outcome and del(8p) was only of borderline significance, the presence of both deletions had a highly significant negative impact on the outcome of splenic MZLs.
AB - Marginal zone B-cell lymphomas (MZLs) have been divided into 3 distinct subtypes (extranodal MZLs of mucosa-associated lymphoid tissue [MALT] type, nodal MZLs, and splenic MZLs). Nevertheless, the relationship between the subtypes is still unclear. We performed a comprehensive analysis of genomic DNA copy number changes in a very large series of MZL cases with the aim of addressing this question. Samples from 218 MZL patients (25 nodal, 57 MALT, 134 splenic, and 2 not better specified MZLs) were analyzed with the Affymetrix Human Mapping 250K SNP arrays, and the data combined with matched gene expression in 33 of 218 cases. MALT lymphoma presented significantly more frequently gains at 3p, 6p, 18p, and del(6q23) (TNFAIP3/A20), whereas splenic MZLs was associated with del(7q31), del(8p). Nodal MZLs did not show statistically significant differences compared with MALT lymphoma while lacking the splenic MZLs-related 7q losses. Gains of 3q and 18q were common to all 3 subtypes. del(8p) was often present together with del(17p) (TP53). Although del(17p) did not determine a worse outcome and del(8p) was only of borderline significance, the presence of both deletions had a highly significant negative impact on the outcome of splenic MZLs.
UR - http://hdl.handle.net/10447/60711
M3 - Article
SN - 0006-4971
VL - 117
SP - 1595
EP - 1604
JO - Blood
JF - Blood
ER -