Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome.

Claudio Tripodo, Ivo Kwee, Cassio P. De Campos, Paola M. V. Rancoita, Ekaterina Chigrinova, Michael Mian, Francesco Bertoni, Stephan Dirnhofer, Catherine Thieblemont, Alessandra Tucci, Miguel A. Piris, Gianluca Gaidano, Govind Bhagat, Emanuele Zucca, Maria Grazia Tibiletti, Silvia Govi, Francesco Forconi, Silvia Uccella, Manuela Mollejo, Luca ArcainiVincenzo Canzonieri, Urban Novak, Roberto Marasca, Valter Gattei, Silvia Franceschetti, Miguel A. Piris, Claudio Doglioni, Luca Baldini, Maurilio Ponzoni, Andrés J. M. Ferreri, Fabio Facchetti, Randy D. Gascoyne, Jean Soulier, Riccardo Dalla Favera, Franco Cavalli, Andrea Rinaldi

Risultato della ricerca: Article

121 Citazioni (Scopus)

Abstract

Marginal zone B-cell lymphomas (MZLs) have been divided into 3 distinct subtypes (extranodal MZLs of mucosa-associated lymphoid tissue [MALT] type, nodal MZLs, and splenic MZLs). Nevertheless, the relationship between the subtypes is still unclear. We performed a comprehensive analysis of genomic DNA copy number changes in a very large series of MZL cases with the aim of addressing this question. Samples from 218 MZL patients (25 nodal, 57 MALT, 134 splenic, and 2 not better specified MZLs) were analyzed with the Affymetrix Human Mapping 250K SNP arrays, and the data combined with matched gene expression in 33 of 218 cases. MALT lymphoma presented significantly more frequently gains at 3p, 6p, 18p, and del(6q23) (TNFAIP3/A20), whereas splenic MZLs was associated with del(7q31), del(8p). Nodal MZLs did not show statistically significant differences compared with MALT lymphoma while lacking the splenic MZLs-related 7q losses. Gains of 3q and 18q were common to all 3 subtypes. del(8p) was often present together with del(17p) (TP53). Although del(17p) did not determine a worse outcome and del(8p) was only of borderline significance, the presence of both deletions had a highly significant negative impact on the outcome of splenic MZLs.
Lingua originaleEnglish
pagine (da-a)1595-1604
Numero di pagine10
RivistaBlood
Volume117
Stato di pubblicazionePublished - 2011

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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    Tripodo, C., Kwee, I., De Campos, C. P., Rancoita, P. M. V., Chigrinova, E., Mian, M., Bertoni, F., Dirnhofer, S., Thieblemont, C., Tucci, A., Piris, M. A., Gaidano, G., Bhagat, G., Zucca, E., Tibiletti, M. G., Govi, S., Forconi, F., Uccella, S., Mollejo, M., ... Rinaldi, A. (2011). Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome. Blood, 117, 1595-1604.